Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

Methods in yeast genetics

1979 • 7,824 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

[12] One-step gene disruption in yeast

1983 • 3,302 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Replacement of chromosome segments with altered DNA sequences constructed in vitro.

1979 • 779 citations

SH2 and SH3 domains

1993 • 697 citations

Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth

1993 • 662 citations

Genetic control of the cell division cycle in yeast *1IV. Genes controlling bud emergence and cytokinesis

1971 • 631 citations

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae.

1990 • 605 citations

Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity.

1990 • 560 citations

Chapter 19 Fluorescence Microscopy Methods for Yeast

1989 • 528 citations

Phenotypic analysis of temperature-sensitive yeast actin mutants

1985 • 512 citations

Bcr encodes a GTPase-activating protein for p21rac

1991 • 474 citations

The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.

1991 • 471 citations

Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae.

1991 • 442 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

Genetic control of bud site selection in yeast by a set of gene products that constitute a morphogenetic pathway

1991 • 411 citations

Multicopy suppression of the cdc24 budding defect in yeast by CDC42 and three newly identified genes including the ras-related gene RSR1.

1989 • 406 citations

Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers

1990 • 376 citations

Requirement for a GTPase-Activating Protein in Vesicle Budding from the Endoplasmic Reticulum

1993 • 375 citations

Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleus

1992 • 343 citations

Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: localization of the CDC3 gene product and the timing of events at the budding site.

1991 • 342 citations

The SIT4 protein phosphatase functions in late G1 for progression into S phase.

1991 • 340 citations

Control of MAP kinase activation by the mitogen-induced threonine/tyrosine phosphatase PAC1

1994 • 331 citations

Association between GTPase activators for Rho and Ras families

1992 • 322 citations

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

1993 • 319 citations

Mutational analysis of SEC4 suggests a cyclical mechanism for the regulation of vesicular traffic.

1989 • 314 citations

Yeast actin-binding proteins: evidence for a role in morphogenesis.

1988 • 304 citations

Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast.

1993 • 301 citations

Control of the yeast bud-site assembly GTPase Cdc42. Catalysis of guanine nucleotide exchange by Cdc24 and stimulation of GTPase activity by Bem3.

1994 • 283 citations

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1

1991 • 280 citations

CDC55, a Saccharomyces cerevisiae Gene Involved in Cellular Morphogenesis: Identification, Characterization, and Homology to the B Subunit of Mammalian Type 2A Protein Phosphatase

1991 • 276 citations

Immunofluorescence localization of the Saccharomyces cerevisiae CDC12 gene product to the vicinity of the 10-nm filaments in the mother-bud neck.

1987 • 273 citations

The BCR gene encodes a novel serine/threonine kinase activity within a single exon

1991 • 273 citations

Purification of profilin from Saccharomyces cerevisiae and analysis of profilin-deficient cells.

1990 • 264 citations

Roles of the CDC24 gene product in cellular morphogenesis during the Saccharomyces cerevisiae cell cycle.

1981 • 264 citations

Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae.

1987 • 259 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

A conserved kinase cascade for MAP kinase activation in yeast

1993 • 255 citations

Actin structure and function: roles in mitochondrial organization and morphogenesis in budding yeast and identification of the phalloidin-binding site.

1993 • 252 citations

Development of cell polarity in budding yeast

1991 • 252 citations

A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases

1989 • 251 citations

Growth site localization of Rho1 small GTP-binding protein and its involvement in bud formation in Saccharomyces cerevisiae.

1994 • 242 citations

rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo.

1993 • 236 citations

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

1992 • 235 citations

Ras-related GTPases and the cytoskeleton.

1992 • 232 citations

[26] Vectors for constitutive and inducible gene expression in yeast

1991 • 230 citations

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains

1992 • 219 citations

Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis.

1991 • 210 citations

The SPA2 protein of yeast localizes to sites of cell growth.

1989 • 204 citations

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

1990 • 204 citations

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.

1994 • 199 citations

Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: Localization of the CDC11 gene product and the timing of events at the budding site

1991 • 197 citations

The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae.

1993 • 197 citations

Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes.

1990 • 188 citations

BUD2 encodes a GTPase-activating protein for Budl/Rsrl necessary for proper bud-site selection in yeast

1993 • 185 citations

Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae.

1992 • 180 citations

Novel human brain cDNA encoding a 34,000 Mr protein n-chimaerin, related to both the regulatory domain of protein kinase C and BCR, the product of the breakpoint cluster region gene

1990 • 174 citations

Alteration of a yeast SH3 protein leads to conditional viability with defects in cytoskeletal and budding patterns.

1993 • 172 citations

Yeast G1 cyclins CLN1 and CLN2 and a GAP-like protein have a role in bud formation.

1993 • 172 citations

Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.

1990 • 172 citations

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1993 • 170 citations

Use of a Screen for Synthetic Lethal and Multicopy Suppressee Mutants To Identify Two New Genes Involved in Morphogenesis in Saccharomyces cerevisiae

1991 • 166 citations

GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats.

1991 • 165 citations

Components required for cytokinesis are important for bud site selection in yeast

1993 • 160 citations

Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

1994 • 159 citations

Yeast RHO3 and RHO4 ras superfamily genes are necessary for bud growth, and their defect is suppressed by a high dose of bud formation genes CDC42 and BEM1.

1992 • 155 citations

BUD POSITION IN SACCHAROMYCES CEREVISIAE

1960 • 146 citations

SIT4 protein phosphatase is required for the normal accumulation of SWI4, CLN1, CLN2, and HCS26 RNAs during late G1.

1992 • 144 citations

Studies concerning the temporal and genetic control of cell polarity in Saccharomyces cerevisiae.

1991 • 137 citations

Hydrolysis of GTP by Sec4 protein plays an important role in vesicular transport and is stimulated by a GTPase-activating protein in Saccharomyces cerevisiae.

1992 • 132 citations

Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

1993 • 123 citations

Genetic Evidence for In Vivo Cross-Specificity of the CaaX-Box Protein Prenyltransferases Farnesyltransferase and Geranylgeranyltransferase-I in Saccharomyces cerevisiae

1993 • 120 citations

Regulation of dimorphism in Saccharomyces cerevisiae: involvement of the novel protein kinase homolog Elm1p and protein phosphatase 2A.

1993 • 113 citations

Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutant

1991 • 112 citations

The SIT4 Protein Phosphatase Functions in Late G₃ for Progression into S Phase

1991 • 108 citations

cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia.

1987 • 107 citations

INITIATION OF BUDDING AND CHITIN-RING

1973 • 102 citations

Inhibition of GTP hydrolysis by Sar1p causes accumulation of vesicles that are a functional intermediate of the ER-to-Golgi transport in yeast

1994 • 96 citations

Alpha 2-chimerin, an SH2-containing GTPase-activating protein for the ras-related protein p21rac derived by alternate splicing of the human n-chimerin gene, is selectively expressed in brain regions and testes.

1993 • 95 citations

Immunofluorescence Localization of the Saccharomyces cerevisiae CDC12 Gene Product to the Vicinity of the 10-nm Filaments in the Mother-Bud Neck

1987 • 95 citations

Budding and cell polarity in Saccharomyces cerevisiae

1991 • 89 citations

Isolation and characterization of a pleiotropic glucose repression resistant mutant of Saccharomyces cerevisiae

1984 • 88 citations

Cell polarity and morphogenesis in Saccharomyces cerevisiae

1992 • 84 citations

Biochemical comparisons of the Saccharomyces cerevisiae Bem2 and Bem3 proteins. Delineation of a limit Cdc42 GTPase-activating protein domain.

1993 • 81 citations

Isolation and characterization of two novel ras superfamily genes in Saccharomyces cerevisiae

1992 • 77 citations

The Fission Yeast dis3⁺ Gene Encodes a 110-kDa Essential Protein Implicated in Mitotic Control

1991 • 77 citations

Genetic evidence for the roles of the bud-site-selection genes BUD5 and BUD2 in control of the Rsr1p (Bud1p) GTPase in yeast.

1993 • 77 citations

Yeast RHO3 and RHO4 ras Superfamily Genes Are Necessary for Bud Growth, and Their Defect Is Suppressed by a High Dose of Bud Formation Genes CDC42 and BEM1

1992 • 76 citations

Isolation and characterization of the fission yeast protein phosphatase gene ppe1+ involved in cell shape control and mitosis.

1993 • 76 citations

bcr genes and transcripts.

1988 • 74 citations

A Synthetic Lethal Screen Identifies SLK1, a Novel Protein Kinase Homolog Implicated in Yeast Cell Morphogenesis and Cell Growth

1992 • 74 citations

The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function.

1991 • 68 citations

Suppression of yeast geranylgeranyl transferase I defect by alternative prenylation of two target GTPases, Rho1p and Cdc42p.

1993 • 68 citations

New SNF genes, GAL11 and GRR1 affect SUC2 expression in Saccharomyces cerevisiae.

1991 • 66 citations

The CDC42 homologue from Caenorhabditis elegans. Complementation of yeast mutation

1993 • 61 citations

Alteration of a Yeast SH3 Protein Leads to Conditional Viability with Defects in Cytoskeletal and Budding Patterns

1993 • 60 citations

RHO gene products, putative small GTP‐binding proteins, are importnat for activation of the CAL1/CDC43 gene product, a protein geranylgeranyltransferase in Saccharomyces cerevisiae

1992 • 57 citations

Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae.

1994 • 55 citations

GRR1 of Saccharomyces cerevisiae Is Required for Glucose Repression and Encodes a Protein with Leucine-Rich Repeats

1991 • 53 citations

Conditional lethality of a yeast strain expressing human RHOA in place of RHO1.

1994 • 50 citations

Inactivation of the Protein Phosphatase 2A Regulatory Subunit A Results in Morphological and Transcriptional Defects in Saccharomyces cerevisiae

1992 • 44 citations

Hydrolysis of GTP by Sec4 Protein Plays an Important Role in Vesicular Transport and Is Stimulated by a GTPase-Activating Protein in Saccharomyces cerevisiae

1992 • 43 citations

The COT2 gene is required for glucose-dependent divalent cation transport in Saccharomyces cerevisiae.

1993 • 40 citations

A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. Cloning and sequence analysis of cDNA, pattern of developmental expression, and biochemical characterization of the protein.

1993 • 36 citations

Molecular Cloning and Expression of a G25K cDNA, the Human Homolog of the Yeast Cell Cycle Gene CDC42

1990 • 35 citations

Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae.

1994 • 35 citations

Regulation of Dimorphism in Saccharomyces cerevisiae: Involvement of the Novel Protein Kinase Homolog Elm1P and Protein Phosphatase 2A

1993 • 32 citations

LRG1 is expressed during speculation inSaccharomyces cerevisiaeand contains motifs similar to LIM and rho/racGAP domains

1994 • 26 citations

The Saccharomyces cerevisiae SRK1 Gene, a Suppressor of bcy1 and ins1, May Be Involved in Protein Phosphatase Function

1991 • 24 citations

The complete sequence of a 19,482 bp segment located on the right arm of Chromosome II from Saccharomyces cerevisiae

1993 • 24 citations

Biochemical and genetic dissection of the Saccharomyces cerevisiae RNA polymerase C53 subunit through the analysis of a mitochondrially mis-sorted mutant construct

1992 • 18 citations

α2-Chimerin, an SH2-Containing GTPase-Activating Protein for the ras-Related Protein p21^rac Derived by Alternate Splicing of the Human n-Chimerin Gene, Is Selectively Expressed in Brain Regions and Testes

1993 • 17 citations

The COT2 Gene Is Required for Glucose-Dependent Divalent Cation Transport in Saccharomyces cerevisiae

1993 • 12 citations

Deleted Work

1955 • 0 citations