High-Dose Granulocyte-Macrophage Colony-Stimulating Factor-Producing Vaccines Impair the Immune Response through the Recruitment of Myeloid Suppressor Cells

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Nitric oxide and the immune response

2001 • 3,222 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

The Central Role of CD4+ T Cells in the Antitumor Immune Response

1998 • 1,332 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

2002 • 657 citations

L-arginine metabolism in myeloid cells controls T-lymphocyte functions

2003 • 580 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

IL-4-Induced Arginase 1 Suppresses Alloreactive T Cells in Tumor-Bearing Mice

2003 • 499 citations

Induction of immunity to prostate cancer antigens: results of a clinical trial of vaccination with irradiated autologous prostate tumor cells engineered to secrete granulocyte-macrophage colony-stimulating factor using ex vivo gene transfer.

1999 • 468 citations

Bioactivity of Autologous Irradiated Renal Cell Carcinoma Vaccines Generated by Ex Vivo Granulocyte-Macrophage Colony-Stimulating Factor Gene Transfer

1998 • 419 citations

Thymic selection of CD8+ single positive cells with a class II major histocompatibility complex-restricted receptor.

1994 • 418 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Derangement of immune responses by myeloid suppressor cells

2003 • 347 citations

GM‐CSF‐based cancer vaccines

2002 • 315 citations

Vaccination With Irradiated, Autologous Melanoma Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor by Adenoviral-Mediated Gene Transfer Augments Antitumor Immunity in Patients With Metastatic Melanoma

2003 • 306 citations

Myeloid cell expansion elicited by the progression of spontaneous mammary carcinomas in c-erbB-2 transgenic BALB/c mice suppresses immune reactivity

2003 • 300 citations

Vaccination With Irradiated Autologous Tumor Cells Engineered to Secrete Granulocyte-Macrophage Colony-Stimulating Factor Augments Antitumor Immunity in Some Patients With Metastatic Non–Small-Cell Lung Carcinoma

2003 • 296 citations

Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

2001 • 245 citations

Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity.

1996 • 185 citations

Mechanisms of immune suppression in patients with head and neck cancer: Influence on the immune infiltrate of the cancer

1996 • 178 citations

Sustaining the graft-versus-tumor effect through posttransplant immunization with granulocyte-macrophage colony-stimulating factor (GM-CSF)–producing tumor vaccines

2000 • 165 citations

Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells

1997 • 157 citations

Cytokine-secreting tumor cell vaccines

2000 • 119 citations

A Universal Granulocyte-Macrophage Colony-Stimulating Factor-Producing Bystander Cell Line for Use in the Formulation of Autologous Tumor Cell-Based Vaccines

1999 • 116 citations

Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

GM-CSF-based cellular vaccines: a review of the clinical experience

2002 • 107 citations

Selective Induction of Dendritic Cells Using Granulocyte Macrophage-Colony Stimulating Factor, But Not fms-Like Tyrosine Kinase Receptor 3-Ligand, Activates Thyroglobulin-Specific CD4+/CD25+ T Cells and Suppresses Experimental Autoimmune Thyroiditis

2003 • 103 citations

Role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. II. Down-regulation of macrophage-mediated cytotoxicity by tumor-derived granulocyte-macrophage colony-stimulating factor.

1991 • 88 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 83 citations

A Phase I Clinical Trial of Lethally Irradiated Allogeneic Pancreatic Tumor Cells Transfected with the GM-CSF Gene for the Treatment of Pancreatic Adenocarcinoma. The Johns Hopkins Oncology Center, Baltimore, Maryland

1998 • 83 citations

A correlation between GM‐CSF gene expression and metastases in murine tumors

1991 • 61 citations

In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery

2003 • 42 citations

Use of Murine Models of Cytokine-Secreting Tumor Vaccines to Study Feasibility and Toxicity Issues Critical to Designing Clinical Trials

1995 • 34 citations

Human prostate carcinoma cell lines secrete GM-CSF and express GM-CSF-receptor on their cell surface.

1996 • 33 citations

Progress reports on immune gene therapy for stage IV renal cell cancer using lethally irradiated granulocyte-macrophage colony-stimulating factor-transduced autologous renal cancer cells

2000 • 22 citations

Pharmacokinetics and pharmacodynamics of granulocyte-macrophage colony-stimulating factor and zidovudine in patients with AIDS and severe AIDS-related complex

1993 • 18 citations

Gene therapy: its potential applications in the treatment of renal-cell carcinoma.

1995 • 12 citations