Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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1995 • 12,086 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Williams Textbook of Endocrinology

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Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

Proteoglycans: Structures And Interactions

1991 • 1,596 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Williams Textbook of Endocrinology

1999 • 1,226 citations

STRUCTURES AND FUNCTIONS OF MULTILIGAND LIPOPROTEIN RECEPTORS: Macrophage Scavenger Receptors and LDL Receptor-Related Protein (LRP)

1994 • 1,175 citations

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

1992 • 1,095 citations

Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis

1996 • 1,002 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

1994 • 797 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor-related protein.

1991 • 627 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Perlecan, basal lamina proteoglycan, promotes basic fibroblast growth factor-receptor binding, mitogenesis, and angiogenesis

1994 • 541 citations

Hepatic uptake of chylomicron remnants

1997 • 478 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 415 citations

Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.

1981 • 391 citations

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

1995 • 355 citations

The Molecular and Genetic Basis of Neurological Disease

1993 • 345 citations

Human apolipoprotein E: the Alzheimer's disease connection

1996 • 325 citations

Stable Expression and Secretion of Apolipoproteins E3 and E4 in Mouse Neuroblastoma Cells Produces Differential Effects on Neurite Outgrowth

1995 • 321 citations

Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α₂‐macroglobulin receptor

1990 • 320 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein.

1995 • 305 citations

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

1993 • 297 citations

The Inhibitory Effect of Apolipoprotein E4 on Neurite Outgrowth Is Associated with Microtubule Depolymerization

1995 • 277 citations

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

1996 • 274 citations

Type III Hyperlipoproteinemia Associated with Apolipoprotein E Deficiency

1981 • 272 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

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Mechanisms by which lipoprotein lipase alters cellular metabolism of lipoprotein(a), low density lipoprotein, and nascent lipoproteins. Roles for low density lipoprotein receptors and heparan sulfate proteoglycans.

1992 • 258 citations

Lipoprotein lipase enhances binding of lipoproteins to heparan sulfate on cell surfaces and extracellular matrix.

1992 • 249 citations

Triglyceride lpases and atherosclerosis

1995 • 243 citations

The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro.

1997 • 239 citations

Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

1994 • 236 citations

Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

1995 • 230 citations

Apolipoprotein E-containing High Density Lipoprotein Promotes Neurite Outgrowth and Is a Ligand for the Low Density Lipoprotein Receptor-related Protein

1996 • 226 citations

Low density lipoprotein receptor internalizes low density and very low density lipoproteins that are bound to heparan sulfate proteoglycans via lipoprotein lipase

1993 • 218 citations

Hepatic endothelial lipase antiserum influences rat plasma low and high density lipoproteins in vivo

1979 • 217 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1991 • 210 citations

Disorders of Lipid Metabolism

1990 • 203 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds lipoprotein lipase and beta-migrating very low density lipoprotein associated with the lipase

1993 • 200 citations

Chylomicron assembly and catabolism: role of apolipoproteins and receptors

1996 • 196 citations

Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans

1993 • 185 citations

The mechanism of assimilation of constituents of chylomicrons, very low density lipoproteins and remnants - a new theory

1975 • 176 citations

Localization of the heparin-releasable lipase in situ in the rat liver

1979 • 168 citations

The low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor binds and mediates catabolism of bovine milk lipoprotein lipase.

1992 • 157 citations

Heparan Sulfate Proteoglycans Participate in Hepatic Lipaseand Apolipoprotein E-mediated Binding and Uptake of Plasma Lipoproteins, Including High Density Lipoproteins

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Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections

1990 • 150 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

1998 • 142 citations

Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.

1994 • 138 citations

Role of apolipoprotein E in the lipolytic conversion of beta-very low density lipoproteins to low density lipoproteins in type III hyperlipoproteinemia.

1984 • 137 citations

Cell-surface heparan sulfate proteoglycans: dynamic molecules mediating ligand catabolism

1997 • 136 citations

Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans

1998 • 134 citations

Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.

1998 • 132 citations

Variable heparan sulfate proteoglycan binding of apolipoprotein E variants may modulate the expression of type III hyperlipoproteinemia.

1994 • 130 citations

Binding of chylomicron remnants and beta-very low density lipoproteins to hepatic and extrahepatic lipoprotein receptors. A process independent of apolipoprotein B48.

1984 • 130 citations

Heparan sulfate proteoglycan and FGF receptor target basic FGF to different intracellular destinations

1993 • 130 citations

The Cellular Internalization and Degradation of Hepatic Lipase Is Mediated by Low Density Lipoprotein Receptor-related Protein and Requires Cell Surface Proteoglycans

1995 • 123 citations

In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway.

1996 • 118 citations

Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG.

1994 • 114 citations

Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.

1989 • 110 citations

Overexpression of Hepatic Lipase in Transgenic Mice Decreases Apolipoprotein B-containing and High Density Lipoproteins

1998 • 109 citations

Hepatic lipase mediates the uptake of chylomicrons and beta-VLDL into cells via the LDL receptor-related protein (LRP)

1996 • 108 citations

Intravenous heparinase inhibits remnant lipoprotein clearance from the plasma and uptake by the liver: in vivo role of heparan sulfate proteoglycans.

1995 • 108 citations

Type III hyperlipoproteinemia associated with apolipoprotein E phenotype E3/3. Structure and genetics of an apolipoprotein E3 variant.

1989 • 103 citations

Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor.

1998 • 97 citations

Identification of a lipolysis-stimulated receptor that is distinct from the LDL receptor and the LDL receptor-related protein

1994 • 96 citations

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

1995 • 94 citations

Heparan sulfate proteoglycans are concentrated on the sinusoidal plasmalemmal domain and in intracellular organelles of hepatocytes.

1985 • 94 citations

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.

1991 • 92 citations

Recognition of chylomicron remnants and β-migrating very-low-density lipoproteins by the remnant receptor of parenchymal liver cells is distinct from the liver α2-macroglobulin-recognition site

1991 • 91 citations

The functional characteristics of a human apolipoprotein E variant (cysteine at residue 142) may explain its association with dominant expression of type III hyperlipoproteinemia.

1992 • 89 citations

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

1994 • 89 citations

Hepatic lipase is abundant on both hepatocyte and endothelial cell surfaces in the liver

1997 • 87 citations

Lipoprotein and receptor interactions in vivo

1995 • 87 citations

Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology.

1985 • 85 citations

Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.

1998 • 82 citations

Apolipoprotein E2 Reduces the Low Density Lipoprotein Level in Transgenic Mice by Impairing Lipoprotein Lipase-mediated Lipolysis of Triglyceride-rich Lipoproteins

1998 • 81 citations

A comparison of the roles of the low density lipoprotein (LDL) receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo

1993 • 78 citations

The LDL-receptor-related protein ??? portrait of a multifunctional receptor

1993 • 78 citations

Relative roles of the LDL receptor, the LDL receptor-like protein, and hepatic lipase in chylomicron remnant removal by the liver.

1996 • 76 citations

Intracellular Localization and Metabolism of Chylomicron Remnants in the Livers of Low Density Lipoprotein Receptor-deficient Mice and ApoE-deficient Mice

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Genetic defects in lipoprotein metabolism. Elevation of atherogenic lipoproteins caused by impaired catabolism

1991 • 74 citations

Enrichment of apolipoprotein B-48 in the LDL density class following in vivo inhibition of hepatic lipase

1986 • 72 citations

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

1993 • 70 citations

Role of Heparan Sulfate Proteoglycans and the LDL Receptor‐Related Protein in Remnant Lipoprotein Metabolisma

1994 • 68 citations

The Molecular and Genetic Basis of Neurological Disease

1997 • 67 citations

Novel members of the low density lipoprotein receptor superfamily and their potential roles in lipid metabolism

1997 • 66 citations

Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism

1995 • 66 citations

Basic fibroblast growth factor (FGF-2) internalization through the heparan sulfate proteoglycans-mediated pathway: an ultrastructural approach.

1995 • 64 citations

Cellular binding site and membrane binding proteins for triglyceride-rich lipoproteins in human monocyte-macrophages and THP-1 monocytic cells.

1994 • 64 citations

The human asialoglycoprotein receptor is a possible binding site for low-density lipoproteins and chylomicron remnants

1991 • 61 citations

Lipoprotein lipase-mediated uptake of lipoprotein in human fibroblasts: evidence for an LDL receptor-independent internalization pathway

1996 • 59 citations

Chinese Hamster Ovary Cells Expressing a Cell Surface-anchored Form of Hepatic Lipase

1996 • 58 citations

Familial apolipoprotein E deficiency and type III hyperlipoproteinemia due to a premature stop codon in the apolipoprotein E gene.

1992 • 58 citations

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.

1994 • 56 citations

Free fatty acids activate a high-affinity saturable pathway for degradation of low-density lipoproteins in fibroblasts from a subject homozygous for familial hypercholesterolemia

1992 • 55 citations

Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E.

1993 • 52 citations

Atherogenic lipoproteins and coronary artery disease: concepts derived from recent advances in cellular and molecular biology.

1985 • 50 citations

Chylomicron remnant uptake is regulated by the expression and function of heparan sulfate proteoglycan in hepatocytes

1998 • 49 citations

Adenovirus-Mediated Gene Transfer of Human Lipoprotein Lipase Ameliorates the Hyperlipidemias Associated with Apolipoprotein E and LDL Receptor Deficiencies in Mice

1997 • 49 citations

Genetic Defects in Lipoprotein Metabolism

1991 • 45 citations

Resistance of a very low density lipoprotein subpopulation from familial dysbetalipoproteinemia to in vitro lipolytic conversion to the low density lipoprotein density fraction.

1983 • 41 citations

Transgenic mice expressing human lipoprotein lipase driven by the mouse metallothionein promoter. A phenotype associated with increased perinatal mortality and reduced plasma very low density lipoprotein of normal size.

1994 • 41 citations

Mechanism of Activation and Functional Significance of the Lipolysis-Stimulated Receptor. Evidence for a Role as Chylomicron Remnant Receptor

1995 • 41 citations

Uptake of hypertriglyceridemic very low density lipoproteins and their remnants by HepG2 cells: the role of lipoprotein lipase, hepatic triglyceride lipase, and cell surface proteoglycans

1997 • 40 citations

Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease.

1996 • 38 citations

Exogenous receptor-associated protein binds to two distinct sites on human fibroblasts but does not bind to the glycosaminoglycan residues of heparan sulfate proteoglycans.

1994 • 36 citations

Recognition of lactoferrin and aminopeptidase M-modified lactoferrin by the liver: involvement of proteoglycans and the remnant receptor

1996 • 33 citations

Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver

1996 • 33 citations

Lipoprotein lipase in liver. Release by heparin and immunocytochemical localization

1988 • 31 citations

Genetic Factors Precipitating Type III Hyperlipoproteinemia in Hypolipidemic Transgenic Mice Expressing Human Apolipoprotein E2

1997 • 29 citations

Mechanisms of Hepatic Chylomicron Remnant Clearance

1997 • 29 citations

Differences in the mechanisms of uptake and endocytosis of small and large chylomicron remnants by rat liver

1996 • 29 citations

Genetic Defects in Lipoprotein Metabolism

1994 • 27 citations

Hepatic lipase function and the accumulation of β-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits

1993 • 26 citations

Uptake and degradation of rat and human very low density (remnant) apolipoprotein by parenchymal and non-parenchymal rat liver cells

1980 • 26 citations

Inhibitory Effect on the Lipolysis-stimulated Receptor of the 39-kDa Receptor-associated Protein

1995 • 26 citations

In vivo removal of beta-VLDL, chylomicron remnants, and alpha 2-macroglobulin in the rat.

1993 • 26 citations

Triacylglycerol hydrolysis in isolated hepatic endosomes.

1992 • 20 citations

Human THP-1 monocyte-macrophage membrane binding proteins and distinct receptor(s) for triglyceride-rich lipoproteins

1995 • 19 citations

Triglyceride-rich lipoproteins of subjects heterozygous for apolipoprotein E2(Lysl46→Gln) are inefficiently converted to cholesterol-rich lipoproteins

1994 • 16 citations

Mechanisms of Hepatic Chylomicron Remnant Clearance

1997 • 10 citations