Lipoprotein binding to canine hepatic membranes. Metabolically distinct apo-E and apo-B,E receptors.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Application to the radioimmunoassay

1973 • 3,279 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

A graphic method for the determination and presentation of binding parameters in a complex system

1967 • 1,524 citations

Role of lysine residues of plasma lipoproteins in high affinity binding to cell surface receptors on human fibroblasts.

1978 • 621 citations

Increased binding of low density lipoprotein to liver membranes from rats treated with 17 alpha-ethinyl estradiol.

1979 • 571 citations

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

1978 • 430 citations

Rapid hepatic clearance of the canine lipoproteins containing only the E apoprotein by a high affinity receptor. Identity with the chylomicron remnant transport process.

1980 • 428 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Inhibition of lipoprotein binding to cell surface receptors of fibroblasts following selective modification of arginyl residues in arginine-rich and B apoproteins.

1977 • 380 citations

Regulation of the hepatic uptake of triglyceride-rich lipoproteins in the rat. Opposing effects of homologous apolipoprotein E and individual C apoproteins.

1980 • 372 citations

Determinants of hepatic uptake of triglyceride-rich lipoproteins and their remnants in the rat.

1980 • 365 citations

Effect of apoproteins on hepatic uptake of triglyceride emulsions in the rat.

1980 • 359 citations

Cholestyramine Promotes Receptor-Mediated Low-Density-Lipoprotein Catabolism

1980 • 357 citations

Hepatic catabolism of rat and human lipoproteins in rats treated with 17 alpha-ethinyl estradiol.

1979 • 322 citations

Characterization of remnants produced during the metabolism of triglyceride-rich lipoproteins of blood plasma and intestinal lymph in the rat.

1975 • 320 citations

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

1979 • 313 citations

Receptor-Mediated Uptake of Lipoprotein-Cholesterol and Its Utilization for Steroid Synthesis in the Adrenal Cortex

1979 • 312 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding

1975 • 266 citations

Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control

1968 • 220 citations

Rate and equilibrium constants for binding of apo-E HDL _c (a cholesterol-induced lipoprotein) and low density lipoproteins to human fibroblasts: Evidence for multiple receptor binding of apo-E HDL _c

1979 • 215 citations

Characterization of the low density lipoprotein receptor in membranes prepared from human fibroblasts.

1978 • 211 citations

Characterization of the sinusoidal transport process responsible for uptake of chylomicrons by the liver.

1978 • 197 citations

Isoprotein specificity in the hepatic uptake of apolipoprotein E and the pathogenesis of familial dysbetalipoproteinemia.

1980 • 191 citations

Low Density Lipoprotein Receptors in Bovine Adrenal Cortex. II. Low Density Lipoprotein Binding to Membranes Prepared from Fresh Tissue*

1979 • 173 citations

Cell surface receptor binding of phospholipid . protein complexes containing different ratios of receptor-active and -inactive E apoprotein.

1980 • 171 citations

Canine hyperlipoproteinemia and atherosclerosis. Accumulation of lipid by aortic medial cells in vivo and in vitro.

1977 • 162 citations

Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.

1976 • 150 citations

Effects of cholestyramine on receptor-mediated plasma clearance and tissue uptake of human low density lipoproteins in the rabbit.

1980 • 145 citations

Tissue sites of degradation of low density lipoprotein: Application of a method for determining the fate of plasma proteins

1979 • 132 citations

Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability.

1977 • 127 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

Apoprotein (E–A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E–A-II) complex.

1978 • 122 citations

Inhibition of receptor-mediated clearance of lysine and arginine modified lipoproteins from the plasma of rats and monkeys

1980 • 120 citations

Rat high density lipoprotein subfraction (HDL3) uptake and catabolism by isolated rat liver parenchymal cells.

1976 • 114 citations

Disparities in the interaction of rat and human lipoproteins with cultured rat fibroblasts and smooth muscle cells. Requirements for homology for receptor binding activity.

1980 • 112 citations

Paradoxical Increase in Rate of Catabolism of Low-Density Lipoproteins after Hepatectomy

1974 • 100 citations

An Electrophoretic Method for the Quantitative Isolation of Human and Swine Plasma Lipoproteins

1974 • 94 citations

Quantification of the hepatic contribution to the catabolism of high density lipoproteins in rats.

1979 • 92 citations

High affinity binding of chylomicron remnants to rat liver plasma membranes.

1979 • 91 citations

The metabolism of chylomicron remnants by isolated perfused rat liver

1977 • 90 citations

Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton.

1977 • 90 citations

The postnatal growth and mitotic activity of the liver of the albino rat

1949 • 84 citations

EVOLUTION OF THE LDL RECEPTOR CONCEPT–FROM CULTURED CELLS TO INTACT ANIMALS *

1980 • 78 citations

Accelerated clearance of low-density and high-density lipoproteins and retarded clearance of E apoprotein-containing lipoproteins from the plasma of rats after modification of lysine residues

1979 • 71 citations

High density lipoprotein catabolism before and after partial hepatectomy

1978 • 71 citations

Isolation of a porcine liver plasma membrane fraction that binds low density lipoproteins

1978 • 56 citations

Low density lipoprotein receptors and catabolism in primary cultures of rabbit hepatocytes

1979 • 43 citations