Relative roles of the LDL receptor, the LDL receptor-like protein, and hepatic lipase in chylomicron remnant removal by the liver.

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

A stable, radioactive substrate emulsion for assay of lipoprotein lipase

1976 • 842 citations

The Liver Sieve: Considerations Concerning the Structure and Function of Endothelial Fenestrae, the Sinusoidal Wall and the Space of Disse

1985 • 689 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Enhanced binding by cultured human fibroblasts of apo-E-containing lipoproteins as compared with low density lipoproteins

1978 • 430 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 415 citations

Lipoprotein abnormalities associated with a familial deficiency of hepatic lipase

1982 • 327 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

1995 • 270 citations

Lipoproteins and the liver sieve: The role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis

1995 • 230 citations

Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.

1983 • 230 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1991 • 210 citations

Postprandial hyperlipidemia and remnant lipoproteins

1994 • 208 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

Chylomicron metabolism

1989 • 139 citations

Transport of beta-very low density lipoproteins and chylomicron remnants by macrophages is mediated by the low density lipoprotein receptor pathway.

1987 • 138 citations

Very low and low density lipoprotein synthesis and secretion by the human hepatoma cell line Hep-G2: effects of free fatty acid.

1988 • 137 citations

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.

1994 • 135 citations

Postprandial Triglyceride Response in Young Adult Men and Familial Risk for Coronary Atherosclerosis

1994 • 125 citations

The 39-kDa Receptor-associated Protein Modulates Lipoprotein Catabolism by Binding to LDL Receptors

1995 • 121 citations

Lactoferrin binding to heparan sulfate proteoglycans and the LDL receptor-related protein. Further evidence supporting the importance of direct binding of remnant lipoproteins to HSPG.

1994 • 114 citations

Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats

1990 • 100 citations

Rates of removal and degradation of chylomicron remnants by isolated perfused rat liver.

1978 • 96 citations

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

1995 • 94 citations

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.

1991 • 92 citations

Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

1994 • 89 citations

A comparison of the roles of the low density lipoprotein (LDL) receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo

1993 • 78 citations

Characterization of the estrogen-induced lipoprotein receptor of rat liver.

1986 • 78 citations

Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat.

1994 • 77 citations

Studies on the etiology of the hyperlipemia in rats fed an atherogenic diet

1980 • 76 citations

Chylomicron-remnant clearance in homozygote and heterozygote Watanabe-heritable-hyperlipidaemic rabbits is defective. Lack of evidence for an independent chylomicron-remnant receptor

1991 • 72 citations

Functional domains of the receptor-associated protein (RAP).

1994 • 65 citations

Free fatty acids activate a high-affinity saturable pathway for degradation of low-density lipoproteins in fibroblasts from a subject homozygous for familial hypercholesterolemia

1992 • 55 citations

Uptake of chylomicron remnants by the liver: further evidence for the modulating role of phospholipids.

1988 • 53 citations

Chylomicron Metabolism in Normal, Cholesterol-fed, and Watanabe Heritable Hyperlipidemic Rabbits

1995 • 45 citations

Lipoprotein metabolism by rat hepatomas. Studies on the etiology of defective dietary feedback inhibition of cholesterol synthesis.

1984 • 45 citations

Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase.

1994 • 40 citations

Exogenous receptor-associated protein binds to two distinct sites on human fibroblasts but does not bind to the glycosaminoglycan residues of heparan sulfate proteoglycans.

1994 • 36 citations

Hepatic Clearance of Plasma Chylomicron Remnants

1992 • 27 citations

Distinct properties of the recognition sites for beta-very low density lipoprotein (remnant receptor) and alpha 2-macroglobulin (low density lipoprotein receptor-related protein) on rat parenchymal cells.

1992 • 26 citations

Hepatic uptake of phospholipid-depleted chylomicrons in vivo. Comparison with the uptake of chylomicron remnants

1981 • 26 citations

Low density lipoprotein receptors in rat adipose cells: subcellular localization and regulation by insulin

1994 • 20 citations

ELISA measurement of LDL receptors

1990 • 19 citations

Expression of rat hepatic lipase in heterologous systems: evidence for different sites for interface binding and catalysis.

1991 • 14 citations

Apoprotein-independent binding of chylomicron remnants to rat liver membranes

1991 • 14 citations

Hepatic clearance of chylomicron remnants m mice lacking apoprotein E

1994 • 13 citations