Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low density lipoprotein receptor.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Efficient Trace-labelling of Proteins with Iodine

1958 • 2,571 citations

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

1992 • 2,216 citations

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

1992 • 2,189 citations

The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observations

1972 • 1,831 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

NHLBI funding policies. Enhancing stability, predictability, and cost control.

1994 • 765 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

Prevention of Atherosclerosis in Apolipoprotein E-Deficient Mice by Bone Marrow Transplantation

1995 • 467 citations

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

1998 • 454 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 415 citations

Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.

1991 • 334 citations

Inhibition of Hepatic Chylomicron Remnant Uptake by Gene Transfer of a Receptor Antagonist

1994 • 311 citations

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

1981 • 302 citations

Familial apolipoprotein E deficiency.

1986 • 300 citations

Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells

1993 • 297 citations

Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages

1997 • 285 citations

RAP, a specialized chaperone, prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors.

1996 • 274 citations

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

1995 • 270 citations

Hepatic uptake of chylomicron remnants in WHHL rabbits: a mechanism genetically distinct from the low density lipoprotein receptor.

1982 • 260 citations

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.

1990 • 239 citations

Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

1994 • 211 citations

Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor

1991 • 210 citations

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.

1995 • 208 citations

The low-density lipoprotein receptor-related protein: double agent or decoy?

1991 • 183 citations

Chylomicron remnant clearance from the plasma is normal in familial hypercholesterolemic homozygotes with defined receptor defects.

1990 • 151 citations

Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections

1990 • 150 citations

Role of hepatic lipase in the uptake and processing of chylomicron remnants in rat liver.

1994 • 142 citations

Chylomicron and chylomicron remnant catabolism

1991 • 123 citations

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

1995 • 94 citations

Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo.

1991 • 92 citations

Intracellular Localization and Metabolism of Chylomicron Remnants in the Livers of Low Density Lipoprotein Receptor-deficient Mice and ApoE-deficient Mice

1995 • 74 citations

Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E.

1993 • 70 citations

Chylomicron remnants: hepatic receptors and metabolism

1995 • 66 citations

Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice.

1994 • 56 citations

Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E.

1993 • 52 citations

Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer's disease.

1996 • 38 citations

Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bone marrow transplantation studies in the mouse

1997 • 30 citations

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

1994 • 22 citations

Interaction of apo E-containing lipoproteins with the LDL receptor-related protein LRP

1997 • 20 citations

Murine bone marrow transplantation as a novel approach to studying the role of macrophages in lipoprotein metabolism and atherogenesis

1996 • 16 citations