Design, Activity, and Structure of a Highly Specific Artificial Endonuclease

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PROCHECK: a program to check the stereochemical quality of protein structures

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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WHAT IF: A molecular modeling and drug design program

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Evolution and Tinkering

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XtalView/Xfit—A Versatile Program for Manipulating Atomic Coordinates and Electron Density

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The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht

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Effective energy function for proteins in solution

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De Novo Protein Design: Fully Automated Sequence Selection

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A revised set of potentials for β‐turn formation in proteins

1994 • 912 citations

A simple physical model for binding energy hot spots in protein–protein complexes

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Native protein sequences are close to optimal for their structures

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Bayesian statistical analysis of protein side‐chain rotamer preferences

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Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

2001 • 591 citations

Engineering polydactyl zinc-finger transcription factors

2002 • 478 citations

Homing endonucleases: keeping the house in order

1997 • 466 citations

Homing endonucleases: structural and functional insight into the catalysts of intron/intein mobility

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High-Resolution Protein Design with Backbone Freedom

1998 • 457 citations

Requirements for double-strand cleavage by chimeric restriction enzymes with zinc finger DNA-recognition domains

2000 • 407 citations

Enzyme-like proteins by computational design

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Directed enzyme evolution

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Crystal Structure of PI-SceI, a Homing Endonuclease with Protein Splicing Activity

1997 • 254 citations

Mechanisms of Intron Mobility

1995 • 248 citations

Group II Introns Designed to Insert into Therapeutically Relevant DNA Target Sites in Human Cells

2000 • 204 citations

Statistical modeling and analysis of the LAGLIDADG family of site- specific endonucleases and identification of an intein that encodes a site-specific endonuclease of the HNH family

1997 • 190 citations

Protein solubility and folding monitored in vivo by structural complementation of a genetic marker protein

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DNA Recognition and Cleavage by the LAGLIDADG Homing Endonuclease I-Cre I

1998 • 148 citations

The structure of I-Crel, a Group I intron-encoded homing endonuclease

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Review: Protein Design—Where We Were, Where We Are, Where We're Going

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I- Ppo I and I- Cre I homing site sequence degeneracy determined by random mutagenesis and sequential in vitro enrichment 1 1Edited by G. Smith

1998 • 121 citations

A novel endonuclease mechanism directly visualized for I-PpoI.

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Mutations altering the cleavage specificity of a homing endonuclease

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Crystal Structure of an Archaeal Intein-encoded Homing Endonuclease PI-PfuI

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Prokaryotic introns and inteins: a panoply of form and function

1995 • 113 citations

A detailed study of the substrate specificity of a chimeric restriction enzyme

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The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites.

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Crystal structure of the thermostable archaeal intron-encoded endonuclease I- Dmo I 1 1Edited by I. A. Wilson

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Directed Evolution of Single Proteins, Metabolic Pathways, and Viruses

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Cleavage and recognition pattern of a double-strand-specific endonuclease (I-CreI) encoded by the chloroplast 23S rRNA intron of Chlamydomonas reinhardtii

1992 • 68 citations

The EcoRI restriction endonuclease with bacteriophage λ DNA. Kinetic studies

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Selection of a Remote Cleavage Site by I-TevI, thetdIntron-encoded Endonuclease

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4 Homing Endonucleases

1993 • 50 citations

On the possibilities and limitations of rational protein design to expand the specificity of restriction enzymes: a case study employing EcoRV as the target

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Genetic Analysis of the Chlamydomonas reinhadtii I-CreI Mobile Intron Homing System in Escherichia coli

1997 • 48 citations

Purification, Biochemical Characterization and Protein-DNA Interactions of the I-CreI Endonuclease Produced in Escherichia Coli

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An in vivo selection system for homing endonuclease activity

2002 • 35 citations