Electrostatics significantly affect the stability of designed homeodomain variants

MOLMOL: A program for display and analysis of macromolecular structures

1996 • 7,169 citations

DREIDING: a generic force field for molecular simulations

1990 • 5,956 citations

Classical Electrostatics in Biology and Chemistry

1995 • 2,801 citations

[14]Determination and analysis of urea and guanidine hydrochloride denaturation curves

1986 • 2,265 citations

Accurate Calculation of Hydration Free Energies Using Macroscopic Solvent Models

1994 • 2,072 citations

Unfolding free energy changes determined by the linear extrapolation method. 1. Unfolding of phenylmethanesulfonyl .alpha.-chymotrypsin using different denaturants

1988 • 1,568 citations

Electrostatic Interactions in Macromolecules: Theory and Applications

1990 • 1,324 citations

De Novo Protein Design: Fully Automated Sequence Selection

1997 • 1,129 citations

Calculating the electrostatic potential of molecules in solution: Method and error assessment

1988 • 1,096 citations

The α-helix dipole and the properties of proteins

1978 • 985 citations

Backbone-dependent Rotamer Library for Proteins Application to Side-chain Prediction

1993 • 910 citations

Calculation of the total electrostatic energy of a macromolecular system: Solvation energies, binding energies, and conformational analysis

1988 • 829 citations

The dead-end elimination theorem and its use in protein side-chain positioning

1992 • 698 citations

Helix capping

1998 • 685 citations

Do salt bridges stabilize proteins? A continuum electrostatic analysis

1994 • 629 citations

Helix propensities of the amino acids measured in alanine‐based peptides without helix‐stabilizing side‐chain interactions

1994 • 601 citations

Measurement of the β-sheet-forming propensities of amino acids

1994 • 584 citations

High-Resolution Protein Design with Backbone Freedom

1998 • 457 citations

Strength and co-operativity of contributions of surface salt bridges to protein stability

1990 • 415 citations

N‐ and C‐capping preferences for all 20 amino acids in α‐helical peptides

1995 • 319 citations

Two exposed amino acid residues confer thermostability on a cold shock protein.

2000 • 301 citations

Enhanced protein thermostability from designed mutations that interact with α-helix dipoles

1988 • 290 citations

Efficient rotamer elimination applied to protein side-chains and related spin glasses

1994 • 279 citations

Internal Stark Effect Measurement of the Electric Field at the Amino Terminus of an α Helix

1992 • 259 citations

Recursive PCR: a novel technique for total gene synthesis

1992 • 234 citations

Automated design of the surface positions of protein helices

1997 • 233 citations

Recombinant Proteins Can Be Isolated from E. coli Cells by Repeated Cycles of Freezing and Thawing

1994 • 225 citations

Energy functions for protein design

1999 • 214 citations

Increasing protein stability by altering long‐range coulombic interactions

1999 • 207 citations

Engineering a Thermostable Protein via Optimization of Charge−Charge Interactions on the Protein Surface

1999 • 207 citations

Computational protein design

1999 • 193 citations

Rational Modification of Protein Stability by the Mutation of Charged Surface Residues

2000 • 187 citations

Electrostatic Screening of Charge and Dipole Interactions with the Helix Backbone

1993 • 168 citations

Conformational splitting: A more powerful criterion for dead-end elimination

2000 • 167 citations

Contribution of Surface Salt Bridges to Protein Stability^,

2000 • 159 citations

Structural studies of the engrailed homeodomain

1994 • 158 citations

De novo protein design. I. in search of stability and specificity

1999 • 127 citations

Effect of a single aspartate on helix stability at different positions in a neutral alanine‐based peptide

1993 • 121 citations

Tanford–Kirkwood electrostatics for protein modeling

1999 • 116 citations

Dissection of helix capping in T4 lysozyme by structural and thermodynamic analysis of six amino acid substitutions at Thr 59

1992 • 107 citations

Electrostatic interactions in macromolecules

1994 • 95 citations

Effect of the N1 residue on the stability of the α‐helix for all 20 amino acids

2001 • 93 citations

Radical performance enhancements for combinatorial optimization algorithms based on the dead-end elimination theorem

1998 • 89 citations

Cooperative helix stabilization by complex Arg–Glu salt bridges

2001 • 72 citations

Salt Bridges Stabilize the Folded Structure of Barnase

2001 • 55 citations

Destabilization of a Protein Helix by Electrostatic Interactions

1995 • 31 citations

Structure of a protein G helix variant suggests the importance of helix propensity and helix dipole interactions in protein design

2000 • 27 citations

Fluctuations between stabilizing and destabilizing electrostatic contributions of ion pairs in conformers of the c-Myc-Max leucine zipper

2000 • 23 citations

Conformational splitting: A more powerful criterion for dead‐end elimination

2000 • 6 citations

Electrostatic interactions in proteins

1987 • 2 citations