U2AF homology motifs: protein recognition in the RRM world

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

1997 • 38,984 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Conserved Structures and Diversity of Functions of RNA-Binding Proteins

1994 • 1,873 citations

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

2003 • 1,415 citations

SMART 4.0: towards genomic data integration

2003 • 968 citations

Alternative pre-mRNA splicing: the logic of combinatorial control

2000 • 892 citations

Comprehensive proteomic analysis of the human spliceosome

2002 • 883 citations

Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin

1994 • 827 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

CDD: a database of conserved domain alignments with links to domain three-dimensional structure

2002 • 673 citations

Analysis of the RNA-recognition motif and RS and RGG domains: conservation in metazoan pre-mRNA splicing factors

1993 • 663 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein

1989 • 601 citations

Insertional mutagenesis in zebrafish rapidly identifies genes essential for early vertebrate development

2002 • 548 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex

1999 • 530 citations

Comparative genomics and evolution of proteins involved in RNA metabolism

2002 • 524 citations

Recognition of Polyadenylate RNA by the Poly(A)-Binding Protein

1999 • 494 citations

Modular Recognition of RNA by a Human Pumilio-Homology Domain

2002 • 490 citations

Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex

1998 • 486 citations

mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.

1986 • 455 citations

Functional recognition of the 3′ splice site AG by the splicing factor U2AF35

1999 • 438 citations

ScanProsite: a reference implementation of a PROSITE scanning tool.

2002 • 425 citations

Expressing the human genome

2001 • 407 citations

Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation

1988 • 401 citations

A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: Domain structure and expression

1986 • 389 citations

Altered imprinted gene methylation and expression in completely ES cell-derived mouse fetuses: association with aberrant phenotypes

1998 • 378 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein

1999 • 370 citations

Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation

1997 • 360 citations

Allosteric Cascade of Spliceosome Activation

2002 • 357 citations

Coordinate Regulation of Transcription and Splicing by Steroid Receptor Coregulators

2002 • 355 citations

Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA

1998 • 349 citations

Stimulatory effect of splicing factors on transcriptional elongation

2001 • 346 citations

The ends of the affair: capping and polyadenylation.

2000 • 340 citations

MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin

2000 • 329 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

Identification of the RNA binding segment of human U1 A protein and definition of its binding site on U1 snRNA.

1989 • 314 citations

Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG

1999 • 290 citations

A Potential Role for U2AF-SAP 155 Interactions in Recruiting U2 snRNP to the Branch Site

1998 • 288 citations

A compensatory base change in human U2 snRNA can suppress a branch site mutation.

1989 • 284 citations

A growth factor-dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression

2002 • 281 citations

Interaction of U2AF ⁶⁵ RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

1996 • 279 citations

From developmental disorder to heritable cancer: it's all in the BMP/TGF-β family

2003 • 270 citations

Both subunits of U2AF recognize the 3′ splice site in Caenorhabditis elegans

1999 • 254 citations

A cooperative interaction between U2AF65 and mBBP/SF1 facilitates branchpoint region recognition

1998 • 253 citations

SAM domains: uniform structure, diversity of function

2003 • 253 citations

Arginine-Serine-Rich Domains Bound at Splicing Enhancers Contact the Branchpoint to Promote Prespliceosome Assembly

2004 • 239 citations

Structural basis for recognition of AU-rich element RNA by the HuD protein.

2001 • 226 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

Structural Basis for the Molecular Recognition between Human Splicing Factors U2AF65 and SF1/mBBP

2003 • 212 citations

Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA

2001 • 210 citations

Molecular basis of sequence-specific recognition of pre-ribosomal RNA by nucleolin

2000 • 207 citations

mRNA Polyadenylate-Binding Protein: Gene Isolation and Sequencing and Identification of a Ribonucleoprotein Consensus Sequence

1986 • 204 citations

Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit.

1992 • 203 citations

A Novel Peptide Recognition Mode Revealed by the X-Ray Structure of a Core U2AF35/U2AF65 Heterodimer

2001 • 203 citations

From structure to function: approaches and limitations.

2000 • 202 citations

Branch nucleophile selection in pre-mRNA splicing: evidence for the bulged duplex model.

1994 • 201 citations

RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins.

1991 • 196 citations

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3

2004 • 191 citations

The yeast MUD2 protein: an interaction with PRP11 defines a bridge between commitment complexes and U2 snRNP addition.

1994 • 188 citations

A novel mode of RBD-protein recognition in the Y14–Mago complex

2003 • 162 citations

Splicing Regulation at the Second Catalytic Step by Sex-lethal Involves 3′ Splice Site Recognition by SPF45

2002 • 162 citations

The FBP Interacting Repressor Targets TFIIH to Inhibit Activated Transcription

2000 • 155 citations

XMAN1, an inner nuclear membrane protein, antagonizes BMP signaling by interacting with Smad1 inXenopusembryos

2003 • 152 citations

Tat-SF1: Cofactor for Stimulation of Transcriptional Elongation by HIV-1 Tat

1996 • 141 citations

The NMR structure of the 38 kDa U1A protein - PIE RNA complex reveals the basis of cooperativity in regulation of polyadenylation by human U1A protein.

2000 • 136 citations

PUF60: A novel U2AF65-related splicing activity

1999 • 135 citations

Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma.

1993 • 123 citations

Structural Characterization of the LEM Motif Common to Three Human Inner Nuclear Membrane Proteins

2001 • 119 citations

Defective Interplay of Activators and Repressors with TFIIH in Xeroderma Pigmentosum

2001 • 118 citations

Structure of the Y14-Magoh Core of the Exon Junction Complex

2003 • 117 citations

Differential recruitment of nuclear receptor coactivators may determine alternative RNA splice site choice in target genes

2004 • 116 citations

A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA

1997 • 111 citations

Stathmin interaction with a putative kinase and coiled-coil-forming protein domains.

1995 • 107 citations

Molecular Cloning and Characterization of CAPER, a Novel Coactivator of Activating Protein-1 and Estrogen Receptors

2002 • 107 citations

Crystal Structure of the Shank PDZ-Ligand Complex Reveals a Class I PDZ Interaction and a Novel PDZ-PDZ Dimerization

2003 • 106 citations

Three protein factors (SF1, SF3 and U2AF) function in pre-splicing complex formation in addition to snRNPs.

1991 • 104 citations

U2AF Homolog Required for Splicing in Vivo

1993 • 100 citations

Conservation of functional domains involved in RNA binding and protein–protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1

1998 • 98 citations

Mammalian U2 snRNP has a sequence-specific RNA-binding activity.

1989 • 98 citations

Transient interaction of BBP/ScSF1 and Mud2 with the splicing machinery affects the kinetics of spliceosome assembly

1999 • 95 citations

The SH3 domain of Eps8 exists as a novel intertwined dimer

1997 • 93 citations

SANE, a Novel LEM Domain Protein, Regulates Bone Morphogenetic Protein Signaling through Interaction with Smad1

2002 • 93 citations

CUS2, a Yeast Homolog of Human Tat-SF1, Rescues Function of Misfolded U2 through an Unusual RNA Recognition Motif

1998 • 91 citations

Evidence that U5 snRNP recognizes the 3' splice site for catalytic step II in mammals

1997 • 90 citations

The Conserved Pre-mRNA Splicing Factor U2AF from Drosophila : Requirement for Viability

1993 • 89 citations

Crystal Structure of GRIP1 PDZ6-Peptide Complex Reveals the Structural Basis for Class II PDZ Target Recognition and PDZ Domain-mediated Multimerization

2003 • 88 citations

half pint Regulates Alternative Splice Site Selection in Drosophila

2002 • 85 citations

Crystal structure of theDrosophilaMago nashi–Y14 complex

2003 • 82 citations

Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects.

1996 • 72 citations

Human SPF45, a Splicing Factor, Has Limited Expression in Normal Tissues, Is Overexpressed in Many Tumors, and Can Confer a Multidrug-Resistant Phenotype to Cells

2003 • 72 citations

U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans

1999 • 70 citations

The HIV-1 Tat cellular coactivator Tat–SF1 is a general transcription elongation factor

1998 • 65 citations

Interaction between Subunits of Heterodimeric Splicing Factor U2AF Is Essential In Vivo

1998 • 55 citations

Sex lethal and U2 small nuclear ribonucleoprotein auxiliary factor (U2AF⁶⁵) recognize polypyrimidine tracts using multiple modes of binding

2003 • 50 citations

A cDNA clone of the hnRNP C proteins and its homology with the single-stranded DNA binding protein UP2

1986 • 48 citations

The small subunit of the splicing factor U2AF is conserved in fission yeast

1996 • 43 citations

Discovering patterns and subfamilies in biosequences.

1996 • 39 citations

The fission yeast prp10(+) gene involved in pre-mRNA splicing encodes a homologue of highly conserved splicing factor, SAP155

1998 • 36 citations

Atrans‐acting factor, isolated by the three‐hybrid system, that influences alternative splicing of the amyloid precursor protein minigene

2000 • 36 citations

RNA Binding Activity of Heterodimeric Splicing Factor U2AF: at Least One RS Domain Is Required for High-Affinity Binding

1998 • 36 citations

Contribution of the C-terminal tail of U1A RBD1 to RNA recognition and protein stability.

1997 • 35 citations

The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF⁶⁵) is essential in vivo but dispensable for activity in vitro

2004 • 35 citations

Characterization of U2AF²⁶, a Splicing Factor Related to U2AF³⁵

2002 • 34 citations

Two cDNAs from the plantArabidopsis thalianathat partially restore recombination proficiency and DNA-damage resistance toE.colimutants lacking recombination-intermediate-resolution activities

1993 • 34 citations

Quantitative RT-PCR reveals a ubiquitous but preferentially neural expression of the KIS gene in rat and human

2003 • 32 citations

Isolation and Mapping of Human Homologues of an Imprinted Mouse GeneU2af1-rs1

1995 • 32 citations

Fourteen Residues of the U1 snRNP-Specific U1A Protein Are Required for Homodimerization, Cooperative RNA Binding, and Inhibition of Polyadenylation

2000 • 30 citations

Specific Ser‐Pro phosphorylation by the RNA‐recognition motif containing kinase KIS

2000 • 28 citations

Gene Expression: The Close Coupling of Transcription and Splicing

2002 • 23 citations

A novel DNA repair enzyme containing RNA recognition, G‐patch and specific splicing factor 45‐like motifs in the protozoan parasite Toxoplasma gondii

2002 • 19 citations

Molecular characterization of a novel fission yeast gene spUAP2 that interacts with the splicing factor spU2AF 59

1997 • 14 citations

Repeat-Induced Point Mutations inPad-1,a Putative RNA Splicing Factor fromNeurospora crassa,Confer Dominant Lethal Effects on Ascus Development

1998 • 7 citations