CD4+ and CD8+ T Cell Survival Is Regulated Differentially by Protein Kinase Cθ, c-Rel, and Protein Kinase B

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

1999 • 6,443 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

NF-κB regulation in the immune system

2002 • 3,804 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase

1999 • 2,147 citations

NF-κB is a target of AKT in anti-apoptotic PDGF signalling

1999 • 1,830 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Direct control of the Forkhead transcription factor AFX by protein kinase B

1999 • 1,080 citations

Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen

1989 • 1,010 citations

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

2000 • 983 citations

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

2002 • 940 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

Induction of NF-κB by the Akt/PKB kinase

1999 • 847 citations

PKB/Akt mediates cell-cycle progression by phosphorylation of p27Kip1 at threonine 157 and modulation of its cellular localization

2002 • 778 citations

The Rel/NF-κB Family Directly Activates Expression of the Apoptosis Inhibitor Bcl-x_L

2000 • 747 citations

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression.

1995 • 740 citations

Phosphorylation of the Transcription Factor Forkhead Family Member FKHR by Protein Kinase B

1999 • 719 citations

OX40 Promotes Bcl-xL and Bcl-2 Expression and Is Essential for Long-Term Survival of CD4 T Cells

2001 • 638 citations

PKB/AKT: functional insights from genetic models

2001 • 611 citations

NF-κB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes

1999 • 526 citations

Control of T Cell Viability

2004 • 367 citations

The Kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136

1998 • 360 citations

4-1BB Promotes the Survival of CD8+ T Lymphocytes by Increasing Expression of Bcl-xL and Bfl-1

2002 • 358 citations

Protein Kinase Cθ in T Cell Activation

2002 • 351 citations

Recent advances in the protein kinase B signaling pathway

2005 • 348 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B

2002 • 333 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

Protein Kinase C θ Affects Ca2+ Mobilization and NFAT Activation in Primary Mouse T Cells

2003 • 320 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes.

1993 • 286 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-κB

1997 • 259 citations

Signaling Life and Death in the Thymus: Timing Is Everything

2003 • 255 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat5

2000 • 234 citations

The NF-κB Cascade Is Important in Bcl-xL Expression and for the Anti-Apoptotic Effects of the CD28 Receptor in Primary Human CD4+ Lymphocytes

2000 • 214 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

The costimulation-regulated duration of PKB activation controls T cell longevity

2004 • 208 citations

Genomic organization, promoter region analysis, and chromosome localization of the mouse bcl-x gene.

1997 • 188 citations

NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ

2000 • 169 citations

Expression of Bcl-2, Bcl-x, and Bax after T cell activation and IL-2 withdrawal.

1995 • 167 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-κB-Dependent Transcription

2002 • 151 citations

Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 • 127 citations

c-Rel Is Required for Chromatin Remodeling Across the IL-2 Gene Promoter

2003 • 120 citations

An essential role for c-FLIP in the efficient development of mature T lymphocytes

2005 • 118 citations

The Mitogen-Induced Increase in T Cell Size Involves PKC and NFAT Activation of Rel/NF-κB-Dependent c-myc Expression

2004 • 109 citations

NF-κB regulates Fas / APO-1 / CD95- and TCR-mediated apoptosis of T lymphocytes

1999 • 87 citations

The IL-2 Receptor Promotes Proliferation,bcl-2andbcl-xInduction, But Not Cell Viability Through the Adapter Molecule Shc

1998 • 85 citations

PKCθ Signals Activation versus Tolerance In Vivo

2004 • 84 citations

OX40 and Bcl-xL Promote the Persistence of CD8 T Cells to Recall Tumor-Associated Antigen

2005 • 84 citations

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

2005 • 80 citations

Complex Formation and Cooperation of Protein Kinase Cθ and Akt1/Protein Kinase Bα in the NF-κB Transactivation Cascade in Jurkat T Cells

2001 • 77 citations

Identification and Characterization of Nuclear Factor κB Binding Sites in the Murine bcl‐χ Promoter

2000 • 74 citations

c-Rel Is Required for the Protection of B Cells from Antigen Receptor-Mediated, But Not Fas-Mediated, Apoptosis

2001 • 71 citations

Innate signals compensate for the absence of PKC-θ duringin vivoCD8+ T cell effector and memory responses

2005 • 70 citations

Protein Kinase C-θ Is an Early Survival Factor Required for Differentiation of Effector CD8+ T Cells

2005 • 62 citations

The Antiapoptotic Protein Bcl-xL Is Dispensable for the Development of Effector and Memory T Lymphocytes

2005 • 62 citations

Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

2000 • 59 citations

Cyclin E and Bcl-xL cooperatively induce cell cycle progression in c-Rel−/− B cells

2003 • 59 citations

Antiapoptotic function of NF-κB in T lymphocytes is influenced by their differentiation status: roles of Fas, c-FLIP, and Bcl-xL

2003 • 50 citations

NF-κB Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo

2005 • 48 citations

Detection of c-rel-related transcripts in mouse hematopoietic tissues, fractionated lymphocyte populations, and cell lines.

1987 • 46 citations

AKT1/PKBα is recruited to lipid rafts and activated downstream of PKC isotypes in CD3‐induced T cell signaling

2003 • 37 citations

The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli.

1990 • 36 citations

Detection of c-rel-Related Transcripts in Mouse Hematopoietic Tissues, Fractionated Lymphocyte Populations, and Cell Lines

1987 • 10 citations