Microglia and Macrophages Are the Major Source of Tumor Necrosis Factor in Permanent Middle Cerebral Artery Occlusion in Mice

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

1985 • 1,240 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain

1985 • 881 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

1994 • 672 citations

Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family.

1993 • 627 citations

Production of tumor necrosis factor-alpha by microglia and astrocytes in culture

1989 • 626 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers.

1987 • 549 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

1985 • 394 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

The Microglial Reaction in the Rat Dorsal Hippocampus following Transient Forebrain Ischemia

1991 • 301 citations

Major Histocompatibility Complex (MHC) Class I Gene Expression in Single Neurons of the Central Nervous System: Differential Regulation by Interferon (IFN)-γ and Tumor Necrosis Factor (TNF)-α

1997 • 284 citations

Cerebral Hypoxia-Ischemia Stimulates Cytokine Gene Expression in Perinatal Rats

1995 • 282 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia

1997 • 269 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method

1996 • 259 citations

Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice.

1997 • 255 citations

The Transcription Factor NF‐κB Mediates Increases in Calcium Currents and Decreases in NMDA‐ and AMPA/Kainate‐Induced Currents Induced by Tumor Necrosis Factor‐α in Hippocampal Neurons

1998 • 252 citations

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

1996 • 247 citations

Induction of interleukin-1β mRNA after focal cerebral ischaemia in the rat

1994 • 236 citations

Cloning and characterization of the myelin basic protein gene from mouse: one gene can encode both 14 kd and 18.5 kd MBPs by alternate use of exons

1985 • 234 citations

Transforming Growth Factor-β₁ Prevents Glutamate Neurotoxicity in Rat Neocortical Cultures and Protects Mouse Neocortex from Ischemic Injury in vivo

1993 • 228 citations

Differential expression, cytokine modulation, and specific functions of type-1 and type-2 tumor necrosis factor receptors in rat glia

1997 • 206 citations

TGF-β1 Protects Hippocampal Neurons Against Degeneration Caused by Transient Global Ischemia

1996 • 202 citations

Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat

1996 • 190 citations

Circulating Antibody against Tumor Necrosis Factor–Alpha Protects Rat Brain from Reperfusion Injury

1998 • 187 citations

Expression of Interleukin-6, c-Fos, and zif268 mRNAs in Rat Ischemic Cortex

1995 • 179 citations

Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain

1998 • 169 citations

Induction of Tumor Necrosis Factor-α in the Mouse Hippocampus following Transient Forebrain Ischemia

1997 • 167 citations

TNF-α transgenic and knockout models of CNS inflammation and degeneration

1997 • 164 citations

Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation

1990 • 163 citations

Activation of mitogen-activated protein kinase cascades during priming of human neutrophils by TNF-α and GM-CSF

1998 • 160 citations

Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury

1997 • 159 citations

Exacerbation of Ischemic Brain Damage by Localized Striatal Injection of Interleukin-1β in the Rat

1998 • 159 citations

Neuroprotective effects of TNF binding protein in focal cerebral ischemia

1997 • 153 citations

Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages.

1995 • 144 citations

Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion

1997 • 132 citations

Tumor necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: evidence for production by microglia and astrocytes.

1997 • 124 citations

Regulation of surface and soluble TNF receptor expression on human monocytes and synovial fluid macrophages by IL-4 and IL-10.

1996 • 102 citations

Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion

1997 • 102 citations

Activation of the A_2A adenosine receptor inhibits nitric oxide production in glial cells

1998 • 77 citations

Expression of Tumor Necrosis Factor α (TNFα) and Interleukin 6 (IL-6) mRNA in Adult Human Astrocytes

1996 • 75 citations

TNFα gene expression is induced in neurones after a hippocampal lesion

1994 • 70 citations

Tumor Necrosis Factor-α Expression in Ischemic Neurons

2000 • 67 citations

Combination of non-radioactive and radioactive in situ hybridization with immunohistochemistry: a new method allowing the simultaneous detection of two mRNAs and one antigen in the same brain tissue section.

1993 • 66 citations

Human ramified microglial cells produce nitric oxide upon Escherichia coli lipopolysaccharide and tumor necrosis factor α stimulation

1995 • 65 citations

Identification and topography of neuronal cell populations expressing; TNFα and IL‐1α in response to hippocampal lesion

1996 • 51 citations

Somatostatin and neuropeptide Y in organotypic slice cultures of the rat hippocampus: An immunocytochemical and in situ hybridization study

1992 • 47 citations

Myelin-induced experimental allergic encephalomyelitis in Lewis rats: tumor necrosis factor α levels in serum and cerebrospinal fluid Immunohistochemical expression in glial cells and macrophages of optic nerve and spinal cord

1996 • 46 citations

Upregulation of NF-κB-Dependent Gene Expression Mediated by the p75 Tumor Necrosis Factor Receptor

1995 • 39 citations

Activation of neutrophil respiratory burst by cytokines and chemoattractants. Regulatory role of extracellular matrix glycoproteins

1998 • 31 citations

Cross-linking of the p55 Tumor Necrosis Factor Receptor Cytoplasmic Domain by a Dimeric Ligand Induces Nuclear Factor-κB and Mediates Cell Death

1995 • 28 citations

THE ROLE OF THE TWO TNF RECEPTORS IN PROLIFERATION, NF-κB ACTIVATION AND DISCRIMINATION BETWEEN TNF AND LTαSIGNALLING IN THE HUMAN MYELOMA CELL LINE OH-2

1996 • 27 citations

Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638.

1995 • 26 citations

Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638

1995 • 20 citations

Glial Filaments in Brain Differentiation and the Transient Expression of Neurofilaments in Purkinje Cell Development^a

1985 • 5 citations