ATP-Mediated Killing of Intracellular Mycobacteria by Macrophages Is a P2X7-Dependent Process Inducing Bacterial Death by Phagosome-Lysosome Fusion

Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

2000 • 2,755 citations

FACS-optimized mutants of the green fluorescent protein (GFP)

1996 • 2,539 citations

Tumor necrosis factor-α is required in the protective immune response against mycobacterium tuberculosis in mice

1995 • 1,643 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Lack of Acidification inMycobacteriumPhagosomes Produced by Exclusion of the Vesicular Proton-ATPase

1994 • 1,289 citations

Tuberculosis: Pathogenesis, Protection and Control

1996 • 962 citations

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

1996 • 869 citations

Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

1998 • 736 citations

Characterization of the Mycobacterium tuberculosis phagosome and evidence that phagosomal maturation is inhibited.

1995 • 680 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Transphosphatidylation by Phospholipase D

1967 • 563 citations

Apoptosis, but not necrosis, of infected monocytes is coupled with killing of intracellular bacillus Calmette-Guérin.

1994 • 512 citations

Tissue distribution of the P2X7 receptor

1997 • 481 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

Inherited interleukin 12 deficiency in a child with bacille Calmette-Guérin and Salmonella enteritidis disseminated infection.

1998 • 405 citations

ATP-Induced Killing of Mycobacteria by Human Macrophages Is Mediated by Purinergic P2Z(P2X7) Receptors

1997 • 392 citations

Impaired Immunity and Enhanced Resistance to Endotoxin in the Absence of Neutrophil Elastase and Cathepsin G

2000 • 384 citations

Evidence that vesicles containing living, virulent Mycobacterium tuberculosis or Mycobacterium avium in cultured human macrophages are not acidic

1991 • 299 citations

Haplotype Mapping and Sequence Analysis of the Mouse Nramp Gene Predict Susceptibility to Infection with Intracellular Parasites

1994 • 261 citations

Mycobacterium tuberculosisCatalase and Peroxidase Activities and Resistance to Oxidative Killing in Human Monocytes In Vitro

1999 • 249 citations

Role of Interleukin-18 (IL-18) in Mycobacterial Infection in IL-18-Gene-Disrupted Mice

1999 • 249 citations

The role of gamma-interferon, vitamin D3 metabolites and tumour necrosis factor in the pathogenesis of tuberculosis.

1987 • 215 citations

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

1998 • 206 citations

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation

1998 • 200 citations

Assessment of Immunity to Mycobacterial Infection with Luciferase Reporter Constructs

1999 • 174 citations

Altered cell signaling and mononuclear phagocyte deactivation during intracellular infection

1994 • 174 citations

ATP-Induced Killing of Virulent Mycobacterium tuberculosis Within Human Macrophages Requires Phospholipase D

2000 • 163 citations

Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto‐nucleotidases

1999 • 156 citations

Role of Iron inNramp1-Mediated Inhibition of Mycobacterial Growth

1999 • 151 citations

Epidemiology of Tuberculosis

2014 • 148 citations

Survival ofMycobacterium aviumandMycobacterium tuberculosisin Acidified Vacuoles of Murine Macrophages

1999 • 135 citations

Nramp Transfection Transfers Ity/Lsh/Bcg-Related Pleiotropic Effects on Macrophage Activation: Influence on Oxidative Burst and Nitric Oxide Pathways

1995 • 133 citations

Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism

1999 • 121 citations

Toxicity of nitrogen oxides and related oxidants on mycobacteria: M. tuberculosis is resistant to peroxynitrite anion

1999 • 113 citations

Growth ofMycobacterium tuberculosisin a Defined Medium Is Very Restricted by Acid pH and Mg²⁺Levels

2000 • 111 citations

Inhibition of phagosome-lysosome fusion in macrophages by certain mycobacteria can be explained by inhibition of lysosomal movements observed after phagocytosis.

1987 • 109 citations

Inhibition of endosome fusion by phospholipase A2 (PLA2) inhibitors points to a role for PLA2 in endocytosis.

1993 • 109 citations

Evidence for a link between iron metabolism and Nramp1 gene function in innate resistance against Mycobacterium avium

1998 • 91 citations

ATP-Mediated Killing ofMycobacterium bovisBacille Calmette-Guérin Within Human Macrophages Is Calcium Dependent and Associated with the Acidification of Mycobacteria-Containing Phagosomes

2001 • 76 citations

Differential potentiation of anti-mycobacterial activity and reactive nitrogen intermediate-producing ability of murine peritoneal macrophages activated by interferon-gamma (IFN-γ) and tumour necrosis factor-alpha (TNF-α)

1998 • 69 citations

A prelysosomal compartment sequesters membrane-impermeant fluorescent dyes from the cytoplasmic matrix of J774 macrophages.

1988 • 69 citations

Regulation of Arachidonic Acid Mobilization in Lipopolysaccharide-activated P388D1 Macrophages by Adenosine Triphosphate

1999 • 33 citations

Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2

1997 • 33 citations

Beta 1 integrin cross-linking inhibits CD16-induced phospholipase D and secretory phospholipase A2 activity and granule exocytosis in human NK cells: role of phospholipase D in CD16-triggered degranulation.

1999 • 30 citations

Enhancement of phospholipase A₂ activation by phosphatidic acid endogenously formed through phospholipase D action in rat peritoneal mast cell

1993 • 25 citations

β1 Integrin Cross-Linking Inhibits CD16-Induced Phospholipase D and Secretory Phospholipase A2 Activity and Granule Exocytosis in Human NK cells: Role of Phospholipase D in CD16-Triggered Degranulation

1999 • 22 citations

Phospholipase D and phosphatidic acid enhance the hydrolysis of phospholipids in vesicles and in cell membranes by human secreted phospholipase A2

1998 • 19 citations

Regulation of Early Endosome Fusion by Phospholipase D Activity

1997 • 12 citations

Tuberculosis in Homosexual Men with HIV Disease

1987 • 9 citations