Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function

Marine toxins

1993 • 810 citations

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels

2000 • 714 citations

Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats

1983 • 658 citations

Sodium channel Na _v 1.6 is localized at nodes of Ranvier, dendrites, and synapses

2000 • 626 citations

Poisonous and venomous marine animals of the world

1988 • 558 citations

Isolation and structure of brevetoxin B from the "red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve)

1981 • 537 citations

Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons

1997 • 511 citations

NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy

1998 • 501 citations

Structures and configurations of ciguatoxin from the moray eel Gymnothorax javanicus and its likely precursor from the dinoflagellate Gambierdiscus toxicus

1990 • 466 citations

Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons

1996 • 424 citations

Ciguatera: recent advances but the risk remains

2000 • 423 citations

Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin

1996 • 412 citations

Seafood and Freshwater Toxins

2000 • 377 citations

Clinical Observations on 3,009 Cases of Ciguatera (Fish Poisoning) in the South Pacific

1979 • 331 citations

Sodium channel α-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system

1997 • 330 citations

The changing face of ciguatera

2001 • 324 citations

Brevetoxins, unique activators of voltage-sensitive sodium channels, bind to specific sites in rat brain synaptosomes.

1986 • 313 citations

Structures of ciguatoxin and its congener

1989 • 310 citations

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na⁺ channel

1987 • 304 citations

Purification and characterization of ciguatoxins from moray eel (Lycodontis javanicus, Muraenidae)

1991 • 293 citations

The structure of CTX3C, a ciguatoxin congener isolated from cultured Gambierdiscus toxicus

1993 • 279 citations

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1983 • 264 citations

Tetrazolium-Based Cell Bioassay for Neurotoxins Active on Voltage-Sensitive Sodium Channels: Semiautomated Assay for Saxitoxins, Brevetoxins, and Ciguatoxins

1993 • 261 citations

Characteristics and function of Ca2+ — and inositol 1,4,5-trisphosphate-releasable stores of Ca2+ in neurons

1992 • 253 citations

The Thecal Structure of a Marine Toxic Dinoflagellate Gambierdiscus toxicus gen. et sp. nov. Collected in a Ciguatera-endemic Area

1979 • 246 citations

Ciguatoxin is a novel type of Na+ channel toxin.

1984 • 245 citations

Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels

1999 • 237 citations

Detection of Sodium Channel Toxins: Directed Cytotoxicity Assays of Purified Ciguatoxins, Brevetoxins, Saxitoxins, and Seafood Extracts

1995 • 234 citations

Neurotoxic marine poisoning

2005 • 232 citations

Ciguatera in Australia: Occurrence, clinical features, pathophysiology and management

1986 • 221 citations

Origin and transfer of toxins involved in ciguatera

1993 • 220 citations

Neurology of ciguatera

2001 • 219 citations

Gambierol: a new toxic polyether compound isolated from the marine dinoflagellate Gambierdiscus toxicus

1993 • 217 citations

Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma X glioma hybrid NG108-15 cells.

1984 • 212 citations

Origins of ciguatera fish poisoning: a new dinoflagellate, Gambierdiscus toxicus Adachi and Fukuyo, definitively involved as a causal agent

1980 • 212 citations

MORPHOLOGY AND MOLECULAR ANALYSES OF THREE TOXIC SPECIES OF GAMBIERDISCUS (DINOPHYCEAE): G. PACIFICUS, SP. NOV., G. AUSTRALES, SP. NOV., AND G. POLYNESIENSIS, SP. NOV.

1999 • 192 citations

OBSERVATION OF SAND‐DWELLING TOXIC DINOFLAGELLATES (DINOPHYCEAE) FROM WIDELY DIFFERING SITES, INCLUDING TWO NEW SPECIES

1995 • 192 citations

Calcium stores in neurons and glia

1994 • 183 citations

Successful Treatment of Ciguatera Fish Poisoning With Intravenous Mannitol

1988 • 180 citations

Structure of Caribbean Ciguatoxin Isolated from Caranx latus

1998 • 176 citations

Ciguatera fish poisoning

2002 • 156 citations

Regulation of phosphatidylinositol turnover in brain synaptoneurosomes: stimulatory effects of agents that enhance influx of sodium ions.

1986 • 151 citations

Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels.

1994 • 148 citations

Isolation and characterisation of Caribbean ciguatoxins from the horse-eye jack (Caranx latus)

1997 • 147 citations

Ciguatera Fish Poisoning

1982 • 146 citations

Ciguatera Fish Poisoning in Miami

1980 • 143 citations

Strain dependent production of ciguatoxin precursors (gambiertoxins) by Gambierdiscus toxicus (Dinophyceae) in culture

1991 • 142 citations

Isolation and structures of new ciguatoxin analogs, 2,3-dihydroxyCTX3C and 51-hydroxyCTX3C, accumulated in tropical reef fish

1998 • 137 citations

Identification of Amino Acid Residues in the Insect Sodium Channel Critical for Pyrethroid Binding

2004 • 131 citations

Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury

2007 • 123 citations

Isolation and Structure of Ciguatoxin-4A, a New Ciguatoxin Precursor, from Cultures of DinoflagellateGambierdiscus toxicusand ParrotfishScarus gibbus

1996 • 121 citations

Oscillatory mechanism in primary sensory neurones

2002 • 116 citations

Isolation and characterisation of Indian Ocean ciguatoxin

2002 • 116 citations

Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A

2003 • 114 citations

Ciguatera in Réunion Island (SW Indian Ocean): Epidemiology and clinical patterns

1996 • 113 citations

Nodal swelling produced by ciguatoxin-induced selective activation of sodium channels in myelinated nerve fibers

1996 • 109 citations

The mechanism of mannitol in reducing ischemic injury: hyperosmolarity or hydroxyl scavenger?

1984 • 107 citations

GAMBIERDISCUS YASUMOTOI SP. NOV. (DINOPHYCEAE), A TOXIC BENTHIC DINOFLAGELLATE FROM SOUTHEASTERN ASIA

1998 • 107 citations

HPLC/Tandem Electrospray Mass Spectrometry for the Determination of Sub-ppb Levels of Pacific and Caribbean Ciguatoxins in Crude Extracts of Fish

1998 • 106 citations

Ciguatera and mannitol: experience with a new treatment regimen

1989 • 105 citations

Effects of ciguatoxin on current and voltage clamped frog myelinated nerve fibre

1986 • 103 citations

Multiple ciguatoxins present in Indian Ocean reef fish

2002 • 97 citations

Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons.

1999 • 95 citations

A radioimmunoassay for the detection of ciguatoxin

1977 • 94 citations

Foodborne disease outbreaks in Australia, 1995 to 2000.

2004 • 93 citations

Synthesis-Based Approach toward Direct Sandwich Immunoassay for Ciguatoxin CTX3C

2003 • 89 citations

Single voltage‐gated K+ channels and their functions in small dorsal root ganglion neurones of rat.

1996 • 89 citations

Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids

1998 • 85 citations

Multiple ciguatoxins in the flesh of fish

1992 • 82 citations

Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in Haiti

1997 • 82 citations

Electrophysiological studies on ciguatera poisoning in man (Part II)

1991 • 80 citations

D‐mannitol, a specific hydroxyl free radical scavenger, reduces the developmental toxicity of hydroxyurea in rabbits

1994 • 78 citations

Ciguatera

1993 • 77 citations

Block of voltage-gated potassium channels by Pacific ciguatoxin-1 contributes to increased neuronal excitability in rat sensory neurons

2004 • 77 citations

Mechanisms of Paresthesiae, Dysesthesiae, and Hyperesthesiae: Role of Na<sup>+</sup> Channel Heterogeneity

1996 • 76 citations

A rapid, simplified enzyme immunoassay stick test for the detection of ciguatoxin and related polyethers from fish tissues

1985 • 75 citations

Ciguatoxin enhances quantal transmitter release from frog motor nerve terminals

1990 • 74 citations

Inhibition of Voltage-Gated Potassium Currents by Gambierol in Mouse Taste Cells

2005 • 73 citations

Pacific ciguatoxin‐1b effect over Na⁺ and K⁺ currents, inositol 1,4,5‐triphosphate content and intracellular Ca²⁺ signals in cultured rat myotubes

2002 • 72 citations

Travel and Ciguatera Fish Poisoning

1992 • 70 citations

The Basis of the Paradoxical Disturbance of Temperature Perception in Ciguatera Poisoning

1993 • 69 citations

Isolation and some properties of ciguatoxin

1989 • 69 citations

The epidemiology of ciguatera fish poisoning

1994 • 69 citations

Traditional remedies used in the Western Pacific for the treatment of ciguatera poisoning

1992 • 68 citations

Study of an outbreak of ciguatera fish poisoning in Hong Kong

2005 • 67 citations

Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels

2003 • 67 citations

The absolute configuration of gambierol, a toxic marine polyether from the dinoflagellate, Gambierdiscus toxicus

1999 • 66 citations

Comparison of three different assays for the assessment of ciguatoxin in fish tissues: Radioimmunoassay, mouse bioassay and In vitro guinea pig atrium assay

1982 • 65 citations

Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes.

1991 • 64 citations

A Simple Membrane Immunobead Assay for Detecting Ciguatoxin and Related Polyethers from Human Ciguatera Intoxication and Natural Reef Fishes

1998 • 63 citations

Characterization of ciguatoxins and ciguatoxin congeners present in ciguateric fish by gradient reverse-phase high-performance liquid chromatography/mass spectrometry

1997 • 62 citations

Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding

2003 • 60 citations

Neurotoxins targetting receptor site 5 of voltage-dependent sodium channels increase the nodal volume of myelinated axons

1999 • 60 citations

The mouse ciguatoxin bioassay: A dose - response curve and symptomatology analysis

1983 • 58 citations

A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage‐dependent sodium channels

2004 • 56 citations

A rapid enzyme-immunoassay for the detection of ciguatoxin in contaminated fish tissues

1983 • 55 citations

Differential expression of sodium channel mRNAs in rat peripheral nervous system and innervated tissues

1990 • 54 citations

Treatment of Ciguatera Fish Poisoning with Amttriptyline and Nifedipine

1987 • 53 citations

Ciguatera toxins : Pharmacology of toxins involved in Ciguatera and related fish poisonings

2000 • 52 citations

[Neurologic manifestations of ciguatera. 3 cases with a neurophysiologic study and examination of one nerve biopsy].

1986 • 51 citations

A new polyether toxin from Davis

1982 • 51 citations

Ciguatera and mannitol: In Vivo and In Vitro assessment in mice

1993 • 51 citations

Effects of ciguatoxin on nerve excitability in rats (Part I)

1991 • 50 citations

Allosteric modulation of neurotoxin binding to voltage-sensitive sodium channels by Ptychodiscus brevis toxin 2.

1987 • 50 citations

Elevation of cytoplasmic calcium concentration stimulates hydrolysis of phosphatidylinositol bisphosphate in chick heart cells: effect of sodium channel activators.

1988 • 50 citations

Ability of some plant extracts, traditionally used to treat ciguatera fish poisoning, to prevent the in vitro neurotoxicity produced by sodium channel activators

2005 • 48 citations

Clinical aspects of ciguatera (fish poisoning) in French Polynesia.

1968 • 47 citations

Recovery of ciguatoxin from fish flesh

1993 • 47 citations

Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles

1986 • 46 citations

Clinical experience with i.v. Mannitol in the treatment of ciguatera.

1992 • 46 citations

Ciguatoxin-2 is a diastereomer of ciguatoxin-3

1993 • 45 citations

Studies on the mode of action of ciguateric toxins

1982 • 45 citations

Differential blockade of neuronal voltage-gated Na+ and K+ channels by antidepressant drugs

2002 • 45 citations

Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones

1998 • 44 citations

A new approach to insect-pest control—combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity

1997 • 44 citations

Detection of Sodium Channel Activators by a Rapid Fluorimetric Microplate Assay

2004 • 43 citations

CIGUATERA: A DISEASE FROM CORAL REEF FISH

1976 • 43 citations

Ciguatera fish poisoning. A southern California epidemic.

1995 • 43 citations

Biomonitoring of ciguatoxin exposure in mice using blood collection cards

2005 • 43 citations

A pilot study of the cognitive and psychological correlates of chronic ciguatera poisoning

2003 • 42 citations

Seafood Toxins

1984 • 42 citations

Ciguatoxin‐induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons

2002 • 41 citations

Symptomatic improvement with amitriptyline in ciguatera fish poisoning.

1986 • 41 citations

Bioassay of Ciguatera Toxin

1961 • 41 citations

Coma due to ciguatera poisoning in Rhode Island

1993 • 40 citations

Effects of ciguatoxin and maitotoxin on the isolated guinea pig atria.

1979 • 40 citations

Ciguatera Fish Poisoning

2000 • 40 citations

Potential benefit of tocainide in the treatment of ciguatera: Report of three cases

1988 • 39 citations

Ciguatera: Ecological, clinical, and socioeconomic perspectives

1993 • 39 citations

Neuroprotectant effects of iso-osmolar d-mannitol to prevent Pacific ciguatoxin-1 induced alterations in neuronal excitability: A comparison with other osmotic agents and free radical scavengers

2005 • 37 citations

Mode of the excitatory and inhibitory actions of ciguatoxin in the guinea-pig vas deferens.

1981 • 36 citations

Ciguatoxin, extracted from poisonous morays eels, causes sodium-dependent calcium mobilization in NG108-15 neuroblastoma × glioma hybrid cells

1993 • 36 citations

Hyperosmolar d-mannitol reverses the increased membrane excitability and the nodal swelling caused by Caribbean ciguatoxin-1 in single frog myelinated axons

1999 • 35 citations

A Cell-Based Assay for Brevetoxins, Saxitoxins, and Ciguatoxins Using a Stably Expressed c-fos–Luciferase Reporter Gene

1997 • 35 citations

The mode of inotropic action of ciguatoxin on guinea‐pig cardiac muscle

1988 • 34 citations

Light and electron microscopic studies of pathologic changes induced in mice by ciguatoxin poisoning

1991 • 34 citations

Neuroexcitatory actions of ciguatoxin on brain regions associated with thermoregulation

1995 • 34 citations

Socioeconomic impacts and management ciguatera in the Pacific.

1992 • 32 citations

Mode of the ciguatoxin-induced supersensitivity in the guinea-pig vas deferens.

1982 • 32 citations

Mode of action of ciguatoxin from the Spanish Mackerel, Scomberomorus commersoni, on the guinea-pig ileum and vas deferens.

1984 • 31 citations

Ciguatoxin extracted from poisonous moray eels Gymnothorax javanicus triggers acetylcholine release from Torpedo cholinergic synaptosomes via reversed Na+ –Ca2+ exchange

1993 • 30 citations

Occurrence of a ciguatoxin-like substance in the Spanish mackerel (Scomberomorus commersoni)

1983 • 29 citations

Ciguatera Fish Poisoning

1990 • 29 citations

A Queensland family with ciguatera after eating coral trout

1997 • 28 citations

Ciguatera poisoning: A report of 35 cases

1975 • 28 citations

Simplified solid‐phase immunobead assay for detection of ciguatoxin and related polyethers

1990 • 27 citations

Evolution of Methods for Assessing Ciguatera Toxins in Fish

1994 • 27 citations

A Pilot Study for the Detection of Acute Ciguatera Intoxication in Human Blood

2002 • 27 citations

Ciguatera Fish Poisoning: Treatment with Intravenous Mannitol

1991 • 26 citations

Action of ciguatoxin on human atrial trabeculae

1992 • 26 citations

Life-threatening bradycardia and hypotension in a patient with ciguatera fish poisoning

1993 • 26 citations

Electrical activity in rat tail artery during asynchronous activation of postganglionic nerve terminals by ciguatoxin‐1

1995 • 25 citations

[Evaluation of the efficacy of mannitol in the treatment of ciguatera in French Polynesia].

1992 • 25 citations

Ciguateric Fishes, Ciguatoxin (CTX) and Ciguatera Poisoning

1991 • 25 citations

The use of mosquitoes (Aedes aegypti) to detect ciguatoxin in surgeon fishes (Ctenochaetus striatus)

1984 • 24 citations

An Analysis of Poison Control Center Reports of Ciguatera Toxicity in Puerto Rico for One Year

1984 • 24 citations

Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles

1988 • 24 citations

Evaluation of the Hawaiian reef fishes with the solid phase immunobead assay

1993 • 23 citations

Differential effects of maitotoxin on ATP secretion and on phosphoinositide breakdown in rat pheochromocytoma cells

1988 • 23 citations

Evaluation of the stick enzyme immunoassay incaranx sp. andseriola dumerili associated with ciguatera

1990 • 23 citations

Effects of ciguatoxin and maitotoxin on isolated rat atria and rabbit duodenum

1984 • 22 citations

Effect of a synthetic pyrethroid deltamethrin on excitability changes following a nerve impulse.

1982 • 22 citations

Simplified solid-phase membrane immunobead assay (MIA) with monoclonal anti-ciguatoxin antibody (MAb-CTX) for detection of ciguatoxin and related polyether toxins.

1998 • 22 citations

Recent methods for detection of seafood toxins: Recent immunological methods for ciguatoxin and related polyethers

1993 • 22 citations

Toxicological biotest on Diptera larvae to detect ciguatoxins and various other toxic substances

1996 • 22 citations

Chick feeding test: a simple system to detect ciguatoxin.

1985 • 22 citations

Sub-nanomolar concentrations of ciguatoxin-1 excite preganglionic terminals in guinea pig sympathetic ganglia

1995 • 22 citations

Muscarinic effects of the Caribbean ciguatoxin C-CTX-1 on frog atrial heart muscle

2002 • 21 citations

Ciguatera: Caribbean and Indo-Pacific fish poisoning.

1983 • 21 citations

Reversal of pacific ciguatoxin-1B effects on myelinated axons by agents used in ciguatera treatment

2000 • 21 citations

Fish poisoning in Hawaii.

1963 • 21 citations

Light and electron microscopic studies of the murine heart after repeated administrations of ciguatoxin or ciguatoxin‐4c

1992 • 21 citations

Comparative action of three major ciguatoxins on guinea-pig atria and ilea

1993 • 20 citations

Gambiertoxin (CTX-4B), purified from wild Gambierdiscus toxicus dinoflagellates, induces Na+-dependent swelling of single frog myelinated axons and motor nerve terminals in situ

1997 • 19 citations

Tetrodotoxin Reverses Brevetoxin Allosteric Inhibition of Scorpion α-Toxin Binding on Rat Brain Sodium Channels

1996 • 18 citations

Modification of the peripheral nerve disturbance in ciguatera poisoning in rats with lidocaine

1993 • 16 citations

Fish poisoning in American Samoa.

1977 • 16 citations

Epidemiology of Seafood Poisoning

2018 • 16 citations

Ciguatera (Fish Poisoning)

1983 • 14 citations

Characterization of marine toxin(s) in Myripristis sp. by immunological, mouse toxicity, and guinea pig assays

1993 • 13 citations

[Mass ciguatera poisoning after eating barracuda in Mexico: prognostic and therapeutic implications].

1997 • 13 citations

Ionic mechanisms involved in the nodal swelling of myelinated axons caused by marine toxins.

2002 • 12 citations

Purified ciguatoxin-induced modifications in excitability of myelinated nerve fibre.

1992 • 12 citations

Reversed Mode Na⁺‐Ca²⁺ Exchange Activated by Ciguatoxin (CTX‐1b) Enhances Acetylcholine Release from Torpedo Cholinergic Synaptosomes^a

1996 • 12 citations

Ciguatoxin-induced changes in acetylcholine release and in cytosolic calcium levels.

1992 • 11 citations

Modulation of the Na+-Ca2+ antiport by its ionic environment: the effect of lithium.

1987 • 11 citations

Immunological studies using monoclonal antibodies for detection of low dalton marine toxins

1993 • 11 citations

The mechanism of respiratory failure in ciguatera poisoning

1969 • 11 citations

Ciguatera fish poisoning in industrial ship crewmembers: a retrospective study in a seaport general practice in Trinidad and Tobago.

2004 • 11 citations

Tetrodotoxin‐Sensitive Ciguatoxin Effects on Quantal Release, Synaptic Vesicle Depletion, and Calcium Mobilizationa

1991 • 10 citations

Spider Neurotoxins Targeting Voltage-Gated Sodium Channels

2005 • 7 citations

SPider Neurotoxins Targeting Voltage-Gated Sodium Channels

2005 • 7 citations

Envenomation and consumption of poisonous seafood

2002 • 5 citations

Screening of traditional remedies used in ciguatera fish poisoning treatment

1992 • 4 citations

Ca2+-Dependent changes of acetylcholine release and IP3 mass in Torpedo cholinergic synaptosomes

1997 • 4 citations

The effect of potential therapeutics on ciguatoxin inhibition of the rat phrenic nerve

1992 • 4 citations

Pilot Study of the Potential Benefit of Tocainide in the Management of Ciguatera Toxicity

1989 • 3 citations

Ca 2+ -DEPENDENT CHANGES OF ACETYLCHOLINE RELEASE AND IP 3 MASS IN TORPEDO CHOLINERGIC SYNAPTOSOMES

1996 • 2 citations