A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage‐dependent sodium channels

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Charge Movement Associated with the Opening and Closing of the Activation Gates of the Na Channels

1974 • 746 citations

Dynamic Rearrangement of the Outer Mouth of a K+ Channel during Gating

1996 • 451 citations

Identification of an Intracellular Peptide Segment Involved in Sodium Channel Inactivation

1988 • 382 citations

The chemistry and biological function of natural marine toxins

2001 • 315 citations

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na⁺ channel

1987 • 304 citations

The structure of CTX3C, a ciguatoxin congener isolated from cultured Gambierdiscus toxicus

1993 • 279 citations

Ciguatoxins and brevetoxins, neurotoxic polyether compounds active on sodium channels

1999 • 237 citations

Total Synthesis of Ciguatoxin CTX3C

2001 • 228 citations

Origins of ciguatera fish poisoning: a new dinoflagellate, Gambierdiscus toxicus Adachi and Fukuyo, definitively involved as a causal agent

1980 • 212 citations

Slow Inactivation in Voltage-Gated Sodium Channels: Molecular Substrates and Contributions to Channelopathies

2001 • 180 citations

Gymnodinium Brevis Sp. Nov., A Cause of Discolored Water and Animal Mortality in the Gulf of Mexico

1948 • 163 citations

Identification of peptide components of the brevetoxin receptor site of rat brain sodium channels.

1994 • 148 citations

Identification of an intracellular peptide segment involved in sodium channel inactivation

1988 • 135 citations

Interaction between fast and slow inactivation in Skm1 sodium channels

1996 • 133 citations

Brevetoxin-3 (PbTx-3) and its derivatives modulate single tetrodotoxin-sensitive sodium channels in rat sensory neurons.

1998 • 122 citations

Depolarizing action of a red-tide dinoflagellate brevetoxin on axonal membranes.

1984 • 118 citations

Practical Total Synthesis of Ciguatoxin CTX3C by Improved Protective Group Strategy

2002 • 115 citations

A mutation in segment I-S6 alters slow inactivation of sodium channels

1997 • 114 citations

Inhibition of brevetoxin binding to the voltage-gated sodium channel by gambierol and gambieric acid-A

2003 • 114 citations

Slow Inactivation in Human Cardiac Sodium Channels

1998 • 100 citations

Differential actions of pacific ciguatoxin-1 on sodium channel subtypes in mammalian sensory neurons.

1999 • 95 citations

Pacific ciguatoxin‐1b effect over Na⁺ and K⁺ currents, inositol 1,4,5‐triphosphate content and intracellular Ca²⁺ signals in cultured rat myotubes

2002 • 72 citations

Tryptophan Scanning of D1S6 and D4S6 C-Termini in Voltage-Gated Sodium Channels

2003 • 68 citations

Type B brevetoxins show tissue selectivity for voltage-gated sodium channels: comparison of brain, skeletal muscle and cardiac sodium channels

2003 • 67 citations

Mechanistic link between lidocaine block and inactivation probed by outer pore mutations in the rat μ1 skeletal muscle sodium channel

1998 • 66 citations

Photoaffinity labeling of the brevetoxin receptor on sodium channels in rat brain synaptosomes.

1991 • 64 citations

Interaction of Scorpion α-Toxins with Cardiac Sodium Channels

2001 • 59 citations

Organic neurotoxins in seafoods

1995 • 53 citations

Ciguatera toxins : Pharmacology of toxins involved in Ciguatera and related fish poisonings

2000 • 52 citations

Residue-Specific Effects on Slow Inactivation at V787 in D2-S6 of Nav1.4 Sodium Channels

2001 • 48 citations

Brevetoxin derivatives that inhibit toxin activity

2000 • 46 citations

Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles

1986 • 46 citations

Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones

1998 • 44 citations

Ciguatoxin‐induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons

2002 • 41 citations

Brevetoxin modulates neuronal sodium channels in two cell lines derived from rat brain.

1999 • 41 citations

The actions of a red tide toxin from Ptychodiscus brevis on single sodium channels in mammalian neuroblastoma cells

1989 • 38 citations

Actions of Ptychodiscus brevis toxins on nerve and muscle membranes

1985 • 35 citations

The mode of inotropic action of ciguatoxin on guinea‐pig cardiac muscle

1988 • 34 citations

The sodium channel activator Brevetoxin-3 uncovers a multiplicity of different open states of the cardiac sodium channel

1992 • 26 citations

Action of ciguatoxin on human atrial trabeculae

1992 • 26 citations

Involvement of local anesthetic binding sites on IVS6 of sodium channels in fast and slow inactivation

2003 • 22 citations

Muscarinic effects of the Caribbean ciguatoxin C-CTX-1 on frog atrial heart muscle

2002 • 21 citations

Comparative action of three major ciguatoxins on guinea-pig atria and ilea

1993 • 20 citations

Negatively charged residues adjacent to IFM motif in the DIII–DIV linker of hNa_V1.4 differentially affect slow inactivation

2003 • 14 citations

The β1 Sodium Channel Subunit Modifies the Interactions of Neurotoxins and Local Anesthetics with the Rat Brain IIA α Sodium Channel in Isolated Membranes but not in Intact Cells

1996 • 14 citations

Reversed Mode Na⁺‐Ca²⁺ Exchange Activated by Ciguatoxin (CTX‐1b) Enhances Acetylcholine Release from Torpedo Cholinergic Synaptosomes^a

1996 • 12 citations

Characteristics of two slow inactivation mechanisms and their influence on the sodium channel activity of frog ventricular myocytes

1998 • 6 citations