Negative inotropic and arrhythmic effects of high doses of ciguatoxin on guinea-pig atria and papillary muscles

[Toxic dinoflagellates].

1982 • 888 citations

Lidocaine block of cardiac sodium channels.

1983 • 660 citations

Role of calcium ions in transient inward currents and aftercontractions induced by strophanthidin in cardiac Purkinje fibres.

1978 • 638 citations

Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs

1984 • 544 citations

Ciguatoxin: Isolation and Chemical Nature

1967 • 286 citations

Increase in intracellular sodium ion activity during stimulation in mammalian cardiac muscle.

1982 • 258 citations

Na-Ca exchange: stoichiometry and electrogenicity

1985 • 256 citations

Calcium-Dependent Action Potentials Produced by Catecholamines in Guinea Pig Atrial Muscle Fibers Depolarized by Potassium

1970 • 253 citations

Ciguatoxin is a novel type of Na+ channel toxin.

1984 • 245 citations

Release of noradrenaline by splenic nerve stimulation and its dependence on calcium

1967 • 222 citations

Ciguatera in Australia: Occurrence, clinical features, pathophysiology and management

1986 • 221 citations

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

1981 • 184 citations

Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction.

1984 • 154 citations

Batrachotoxin as a tool to study voltage-sensitive sodium channels of excitable membranes

1985 • 145 citations

Cardioactive substances that prolong the open state of sodium channels

1982 • 132 citations

The relationship between intracellular calcium and contraction in calcium‐overloaded ferret papillary muscles.

1985 • 110 citations

Effects of ciguatoxin on current and voltage clamped frog myelinated nerve fibre

1986 • 103 citations

Voltage- and use-dependent effects of lidocaine on sodium current in rat single ventricular cells.

1983 • 90 citations

Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.

1974 • 82 citations

The role of intracellular sodium activity in the anti‐arrhythmic action of local anaesthetics in sheep Purkinje fibres.

1983 • 71 citations

Effect of calcium on strophanthidin-induced electrical and mechanical toxicity in cardiac Purkinje fibers

1979 • 64 citations

The intracellular sodium activity of sheep heart Purkinje fibres: effects of local anaesthetics and tetrodotoxin

1980 • 60 citations

The relationship among intracellular sodium activity, calcium, and strophanthidin inotropy in canine cardiac Purkinje fibers.

1984 • 55 citations

Ciguatoxin from the flesh and viscera of the barracuda, Sphyraena jello

1984 • 50 citations

Fluctuations in intracellular calcium concentration and their effect on tonic tension in canine cardiac Purkinje fibres.

1985 • 50 citations

Strophanthidin inotropy: Role of intracellular sodium ion activity and sodium-calcium exchange

1985 • 47 citations

Direct and indirect effects of ciguatoxin on guinea-pig atria and papillary muscles

1986 • 46 citations

Studies on the mode of action of ciguateric toxins

1982 • 45 citations

Intracellular sodium and the positive inotropic effect of veratridine and cardiac glycoside in sheep Purkinje fibers.

1986 • 42 citations

The effects of grayanotoxin I and alpha-dihydrograyanotoxin II on guinea-pig myocardium.

1977 • 34 citations

Mode of action of ciguatoxin from the Spanish Mackerel, Scomberomorus commersoni, on the guinea-pig ileum and vas deferens.

1984 • 31 citations

Norepinephrine release by ventricular stimulation: effect on fibrillation thresholds

1980 • 28 citations

Effects of calcium on the local anesthetic suppression of ionic conductances in squid axon membranes.

1976 • 23 citations

Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine

1984 • 22 citations

Marine toxins from the Pacific—IV Pharmacology of ciguatoxin(s)

1968 • 18 citations

Comparative pharmacological actions of ciguatoxin and tetrodotoxin, a preliminary account

1968 • 17 citations

Effect of alpha‐dihydro‐grayanotoxin‐II on the electrical activity of the rabbit sino‐atrial node.

1984 • 16 citations

Effects of lidocaine, procaine, procainamide and quinidine on electrophysiological properties of cultured embryonic chick hearts

1985 • 16 citations

Two potentially arrhythmogenic mechanisms of adrenaline action in cardiac muscle

1984 • 14 citations

Rate-force relationship and calcium overload in canine purkinje fibers†

1986 • 13 citations

Effect of Adrenergic Activators and Inhibitors on the Electrical Activity of the Heart

1980 • 12 citations

Ciguatera poisoning in North-West Viti Levu, Fiji Islands.

1975 • 12 citations

The mechanism of respiratory failure in ciguatera poisoning

1969 • 11 citations

Interactions of norepinephrine and strophanthidin in cardiac Purkinje fibers

1981 • 11 citations

The role of intracellular sodium activity in the inotropy potentiation among high [Ca]o' norepinephrine and strophanthidin.

1985 • 6 citations

Interactions between ciguatoxin and local anethetics on the guinea-pig left atria

1985 • 3 citations

Conformational aspects of the antifibrillatory activity of procaine

1976 • 1 citations