Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

NMRPipe: A multidimensional spectral processing system based on UNIX pipes

1995 • 15,623 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

[26] Raster3D: Photorealistic molecular graphics

1997 • 3,784 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Acetylcholinesterase — new roles for an old actor

2001 • 1,289 citations

Molecular and cellular biology of cholinesterases

1993 • 1,192 citations

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

1996 • 1,058 citations

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase.

1993 • 872 citations

Click Chemistry In Situ: Acetylcholinesterase as a Reaction Vessel for the Selective Assembly of a Femtomolar Inhibitor from an Array of Building Blocks

2002 • 714 citations

Structure of acetylcholinesterase complexed with E2020 (Aricept®): implications for the design of new anti-Alzheimer drugs

1999 • 688 citations

The Cholinesterases: From Genes to Proteins

1994 • 650 citations

Relationship between sequence conservation and three‐dimensional structure in a large family of esterases, lipases, and related proteins

1993 • 570 citations

Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

1993 • 431 citations

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (–)-huperzine A

1997 • 360 citations

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1975 • 357 citations

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

1995 • 347 citations

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs.

1966 • 308 citations

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

2000 • 302 citations

Structure of acetylcholinesterase complexed with (−)‐galanthamine at 2.3 Å resolution

1999 • 284 citations

Crystal structure of an acetylcholinesterase–fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1995 • 236 citations

Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

1992 • 220 citations

Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

1994 • 181 citations

Molecular cloning of mouse acetylcholinesterase: Tissue distribution of alternatively spliced mRNA species

1990 • 168 citations

Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.

1991 • 158 citations

Enzymes of the Cholinesterase Family

1995 • 141 citations

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

2000 • 141 citations

Thioflavin T Is a Fluorescent Probe of the Acetylcholinesterase Peripheral Site That Reveals Conformational Interactions between the Peripheral and Acylation Sites

2001 • 134 citations

Acetylthiocholine Binds to Asp74 at the Peripheral Site of Human Acetylcholinesterase as the First Step in the Catalytic Pathway

2000 • 132 citations

Crystal Structure of Mouse Acetylcholinesterase

1999 • 128 citations

Fasciculins, anticholinesterase toxins from the venom of the green mamba Dendroaspis angusticeps.

1984 • 123 citations

Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase

1995 • 123 citations

Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

1993 • 110 citations

Fasciculin 2 Binds to the Peripheral Site on Acetylcholinesterase and Inhibits Substrate Hydrolysis by Slowing a Step Involving Proton Transfer during Enzyme Acylation

1995 • 102 citations

Nonequilibrium Analysis Alters the Mechanistic Interpretation of Inhibition of Acetylcholinesterase by Peripheral Site Ligands

1998 • 96 citations

“Back Door” Opening Implied by the Crystal Structure of a Carbamoylated Acetylcholinesterase

1999 • 91 citations

The Adhesion Function on Acetylcholinesterase Is Located at the Peripheral Anionic Site

1999 • 85 citations

1.9-A resolution structure of fasciculin 1, an anti-acetylcholinesterase toxin from green mamba snake venom.

1992 • 84 citations

Fluorescence energy transfer on acetylcholinesterase: spatial relationship between peripheral site and active center

1980 • 83 citations

Cloning and Expression of Acetylcholinesterase from Venom

1996 • 83 citations

Allosteric Modulation of Acetylcholinesterase Activity by Peripheral Ligands Involves a Conformational Transition of the Anionic Subsite

1995 • 82 citations

Allosteric Control of Acetylcholinesterase Catalysis by Fasciculin

1995 • 79 citations

Relative binding sites of pharmacologically active ligands on bovine erythrocyte acetylcholinesterase.

1972 • 69 citations

Differential effects of "peripheral" site ligands on Torpedo and chicken acetylcholinesterase.

1994 • 62 citations

Soluble monomeric acetylcholinesterase from mouse: Expression, purification, and crystallization in complex with fasciculin

1996 • 62 citations

Spectroscopic studies on acetylcholinesterase: influence of peripheral-site occupation on active-center conformation

1981 • 48 citations

Expression and Activity of Mutants of Fasciculin, a Peptidic Acetylcholinesterase Inhibitor from Mamba Venom

1997 • 46 citations

Structure of a complex of the potent and specific inhibitor BW284C51 withTorpedo californicaacetylcholinesterase

2002 • 41 citations

Entering a New Phase

2001 • 41 citations

Reversibly Bound and Covalently Attached Ligands Induce Conformational Changes in the Omega Loop, Cys69–Cys96, of Mouse Acetylcholinesterase

2001 • 40 citations

Ligand-induced conformational changes in acetylcholinesterase investigated with fluorescent phosphonates

1979 • 40 citations

Inhibitors of Different Structure Induce Distinguishing Conformations in the Omega Loop, Cys69–Cys96, of Mouse Acetylcholinesterase

2002 • 28 citations

Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites

1986 • 28 citations

Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase.

1987 • 19 citations

Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates

2001 • 16 citations

Effects of Mg2+ and Ca2+ on soluble and membrane-bound acetylcholinesterase from electrophorus electricus

1974 • 12 citations

Different effects of two peripheral anionic site-binding ligands on acetylcholinesterase active-site gorge topography revealed by electron paramagnetic resonance

1995 • 10 citations

Computer Modeling of Acetylcholinesterase and Acetylcholinesterase-Ligand Complexes

1995 • 3 citations