Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Enzyme and metabolic inhibitors

1963 • 1,529 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Comparison of butyrylcholinesterase and acetylcholinesterase

1989 • 536 citations

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1975 • 357 citations

Amino acid residues controlling acetylcholinesterase and butyrylcholinesterase specificity

1993 • 311 citations

Conversion of acetylcholinesterase to butyrylcholinesterase: modeling and mutagenesis.

1992 • 286 citations

CHOLINESTERASES IN THE BLOOD OF MAN

1940 • 256 citations

Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.

1992 • 220 citations

Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

1990 • 208 citations

Relationships between apparent binding energies measured in site-directed mutagenesis experiments and energetics of binding and catalysis

1988 • 172 citations

Molecular cloning of mouse acetylcholinesterase: Tissue distribution of alternatively spliced mRNA species

1990 • 168 citations

Role of the peripheral anionic site on acetylcholinesterase: inhibition by substrates and coumarin derivatives.

1991 • 158 citations

Mutagenesis of essential functional residues in acetylcholinesterase.

1990 • 140 citations

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

1992 • 136 citations

Location of disulfide bonds within the sequence of human serum cholinesterase.

1987 • 114 citations

Ligand binding properties of acetylcholinesterase determined with fluorescent probes

1974 • 112 citations

The human gene encoding acetylcholinesterase is located on the long arm of chromosome 7.

1992 • 101 citations

The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580—-Ala mutant.

1991 • 99 citations

Polymorphism of Pseudocholinesterase in Torpedo marmorata Tissues: Comparative Study of the Catalytic and Molecular Properties of this Enzyme with Acetylcholinesterase

1985 • 91 citations

Synthesis and in vitro properties of a powerful quaternary methylphosphonate inhibitor of acetylcholinesterase

1986 • 78 citations

Phenotypic and molecular biological analysis of human butyrylcholinesterase variants

1990 • 75 citations

Chiral reactions of acetylcholinesterase probed with enantiomeric methylphosphonothioates

1989 • 62 citations

Proposed nomenclature for human butyrylcholinesterase genetic variants identified by DNA sequencing

1991 • 61 citations

Post-translational modifications of Drosophila acetylcholinesterase. In vitro mutagenesis and expression in Xenopus oocytes.

1992 • 58 citations

Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE.

1992 • 56 citations

Mapping the human acetylcholinesterase gene to chromosome 7q22 by fluorescent in situ hybridization coupled with selective PCR amplification from a somatic hybrid cell panel and chromosome-sorted DNA libraries

1992 • 54 citations

Molecular Mechanisms for Hydrolytic Enzyme Action. II. Inhibition of Acetyl-cholinesterase by Excess Substrate

1961 • 50 citations

A steady-state kinetic model of butyrylcholinesterase from horse plasma

1974 • 38 citations

Assignment of the gene for acetylcholinesterase to distal mouse chromosome 5

1992 • 10 citations