Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

USE OF GLASS ELECTRODES TO MEASURE ACIDITIES IN DEUTERIUM OXIDE^1,2

1960 • 2,132 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Molecular Architecture and Biological Reactions

1946 • 835 citations

Methods in yeast genetics, laboratory manual

1987 • 733 citations

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae.

1984 • 477 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

Advances in inorganic biochemistry

1980 • 349 citations

Isotope effects on enzyme-catalyzed reactions

1992 • 323 citations

Functional Tyrosyl Residues in the Active Center of Bovine Pancreatic Carboxypeptidase A^*

1963 • 302 citations

Refined crystal structure of the potato inhibitor complex of carboxypeptidase A at 2.5 Å resolution

1982 • 260 citations

On the size of the active site in proteases II. Carboxypeptidase-A

1967 • 152 citations

Site-directed mutagenesis shows that tyrosine 248 of carboxypeptidase A does not play a crucial role in catalysis

1985 • 117 citations

Kinetics of carboxypeptidase A. pH dependence of tripeptide hydrolysis catalyzed by zinc, cobalt, and manganese enzymes

1970 • 105 citations

The Reaction of Carboxypeptidase A with Hippuryl-DL-β-Phenyllactate^*

1964 • 102 citations

The Kinetics of Some Carboxypeptidase A and Acetylcarboxypeptidase A Catalyzed Hydrolyses^*

1966 • 94 citations

Rat preprocarboxypeptidase A: cDNA sequence and preliminary characterization of the gene.

1982 • 91 citations

The Functional Tyrosyl Residues of Carboxypeptidase A. Nitration with Tetranitromethane^*

1967 • 86 citations

[58] Carboxypeptidase inhibitor from potatoes

1981 • 78 citations

Acetylcarboxypeptidase^*

1963 • 76 citations

Carboxypeptidase A. Mechanistic analysis

1972 • 71 citations

Mechanism of action of carboxypeptidase A in ester hydrolysis.

1976 • 66 citations

Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: comparative studies of the pH dependencies of the native and Phe-248-mutant forms

1986 • 51 citations

The pH dependence of the nitrotyrosine-248 and arsanilazotyrosine-248 carboxypeptidase A catalyzed hydrolysis of O-(trans-p-chlorocinnamoyl)-L-.beta.-phenyllactate

1976 • 50 citations

Spectroscopic Studies of the Exposure of Tyrosine Residues in Proteins with Special Reference to the Subtilisins

1971 • 49 citations

Species Variation of the RNA Methylases^*

1964 • 34 citations

Catalytic conformation of carboxypeptidase A

1983 • 33 citations

Affinity chromatographic sorting of carboxypeptidase a and its chemically modified derivatives

1980 • 31 citations

EFFECT OF D ₂ O ON THE CARBOXYPEPTIDASE-CATALYZED HYDROLYSIS OF O -( trans -CINNAMOYL)-L-β-PHENYLLACTATE AND N-(N-BENZOYLGLYCYL)-L-PHENYLALANINE

1969 • 25 citations

Functional tyrosyl residues of carboxypeptidase A. The effect of protein structure on the reactivity of tyrosine-198

1978 • 23 citations

A peptidase-inactive derivative of carboxypeptidase A modified specifically at tyrosine 248. Cobalt(III) (ethylenediamine-N,N'-diacetato) (arsanilazotyrosinato 248 carboxypeptidase A).

1979 • 15 citations