A peptidase-inactive derivative of carboxypeptidase A modified specifically at tyrosine 248. Cobalt(III) (ethylenediamine-N,N'-diacetato) (arsanilazotyrosinato 248 carboxypeptidase A).

Solid Phase Peptide Synthesis

1970 • 544 citations

Carboxypeptidase A: A Protein and an Enzyme

1971 • 396 citations

The Porcine Pancreatic Carboxypeptidase A System

1963 • 367 citations

Functional Tyrosyl Residues in the Active Center of Bovine Pancreatic Carboxypeptidase A^*

1963 • 302 citations

Carboxypeptidase A. Differences in the mechanisms of ester and peptide hydrolysis

1974 • 148 citations

THE STRUCTURE OF CARBOXYPEPTIDASE A, VI. SOME RESULTS AT 2.0-Å RESOLUTION, AND THE COMPLEX WITH GLYCYL-TYROSINE AT 2.8-Å RESOLUTION

1967 • 126 citations

Kinetics of carboxypeptidase A. I. Hydrolysis of carbobenzoxyglycyl-L-phenylalanine, benzoylglycyl-L-phenylalanine, and hippuryl-DL-.beta.-phenyllactic acid by metal-substituted and acetylated carboxypeptidases

1968 • 113 citations

Kinetics of carboxypeptidase A. II. Inhibitors of the hydrolysis of oligopeptides

1970 • 103 citations

The Reaction of Carboxypeptidase A with Hippuryl-DL-β-Phenyllactate^*

1964 • 102 citations

Spectral properties of cobalt carboxypeptidase. Effects of substrates and inhibitors

1971 • 96 citations

The Structure of Carboxypeptidase A

1967 • 85 citations

Unified picture of mechanisms of catalysis by carboxypeptidase A.

1977 • 83 citations

STRUCTURAL REQUIREMENTS OF SPECIFIC SUBSTRATES FOR CARBOXYPEPTIDASE

1949 • 73 citations

A model for substrate binding and kinetics of carboxypeptidase A

1968 • 72 citations

Carboxypeptidase A. Mechanistic analysis

1972 • 71 citations

Differences between the Conformation of Arsanilazotyrosine 248 of Carboxypeptidase A in the Crystalline State and in Solution

1971 • 68 citations

Esterase activity of zinc neutral proteases

1976 • 64 citations

Environment and conformation dependent sensitivity of the arsanilazotyrosine-248 carboxypeptidase A chromophore

1975 • 64 citations

The pH dependence of the nitrotyrosine-248 and arsanilazotyrosine-248 carboxypeptidase A catalyzed hydrolysis of O-(trans-p-chlorocinnamoyl)-L-.beta.-phenyllactate

1976 • 50 citations

Azocarboxypeptidase: Functional Consequences of Tyrosyl and Histidyl Modification^*

1967 • 50 citations

Chemical modification of carboxypeptidase A crystals. Azo coupling with tyrosine-248

1972 • 44 citations

The Evaluation of the Kinetic Constants of Enzyme Catalyzed Reactions

1953 • 43 citations

Metallocarboxypeptidase-Inhibitor Complexes^*

1964 • 41 citations

Binding of nucleotide to cation-free G-actin

1971 • 25 citations

Functional tyrosyl residues of carboxypeptidase A. The effect of protein structure on the reactivity of tyrosine-198

1978 • 23 citations

Torsional strain considerations in the mechanism of the proteolytic enzymes, with particular application to carboxypeptidase A

1975 • 22 citations

Multiple inhibitor binding to arsanilazotyrosine-248 carboxypeptidase A

1978 • 21 citations

Development of a method for the incorporation of substitution-inert metal ions into proteins. Site-specific modification of arsanilazotyrosine-248 carboxypeptidase A with cobalt(III)

1979 • 11 citations