Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

2000 • 890 citations

T Cell Receptor Signaling Precedes Immunological Synapse Formation

2002 • 695 citations

Bcl10 Is a Positive Regulator of Antigen Receptor–Induced Activation of NF-κ B and Neural Tube Closure

2001 • 551 citations

A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes.

1989 • 455 citations

Structural Basis for Relief of Autoinhibition of the Dbl Homology Domain of Proto-Oncogene Vav by Tyrosine Phosphorylation

2000 • 381 citations

CARMA1 is a critical lipid raft–associated regulator of TCR-induced NF-κB activation

2002 • 338 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

Activation and inhibition of lymphocytes by costimulation

2002 • 332 citations

The immunological synapse and CD28-CD80 interactions

2001 • 303 citations

Antigen-induced translocation of PKC-θ to membrane rafts is required for T cell activation

2001 • 301 citations

NF-kappa B activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-theta

2000 • 291 citations

A requirement for CARMA1 in TCR-induced NF-κB activation

2002 • 288 citations

Protein Kinase C-θ Participates in NF-κB Activation Induced by CD3-CD28 Costimulation through Selective Activation of IκB Kinase β

2000 • 259 citations

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

1999 • 252 citations

Rottlerin Is a Mitochondrial Uncoupler That Decreases Cellular ATP Levels and Indirectly Blocks Protein Kinase Cδ Tyrosine Phosphorylation

2001 • 225 citations

CD28 Mediates Transcriptional Upregulation of the Interleukin-2 (IL-2) Promoter through a Composite Element Containing the CD28RE and NF-IL-2B AP-1 Sites

1997 • 224 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

CD28 as a Molecular Amplifier Extending TCR Ligation and Signaling Capabilities

2001 • 183 citations

CD28‐mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: Evidence for functionally distinct forms of CD28

1997 • 171 citations

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

2001 • 171 citations

NF-κB activation induced by T cell receptor/CD28 costimulation is mediated by protein kinase C-θ

2000 • 169 citations

Characterization of a cell surface-expressed disulfide-linked dimer involved in murine T cell activation.

1988 • 160 citations

Activation Mechanisms of Protein Kinase C: Maturation, Catalytic Activation, and Targeting

2002 • 148 citations

CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

2002 • 142 citations

The Physical Association of Protein Kinase Cθ with a Lipid Raft-Associated Inhibitor of κB Factor Kinase (IKK) Complex Plays a Role in the Activation of the NF-κB Cascade by TCR and CD28

2000 • 136 citations

RelA Is a Potent Transcriptional Activator of the CD28 Response Element within the Interleukin 2 Promoter

1995 • 131 citations

Translocation of PKCθ in T cells is mediated by a nonconventional, PI3-K– and Vav-dependent pathway, but does not absolutely require phospholipase C

2002 • 131 citations

Expression cloning of the early activation antigen CD69, a type II integral membrane protein with a C-type lectin domain.

1993 • 125 citations

Triggering of T cell proliferation through CD28 induces GATA‐3 and promotes T helper type 2 differentiationin vitroandin vivo

1999 • 108 citations

CD28 Signaling via VAV/SLP-76 Adaptors

2001 • 107 citations

Involvement of Rel, Fos, and Jun proteins in binding activity to the IL-2 promoter CD28 response element/AP-1 sequence in human T cells.

1997 • 104 citations

CD69 Expression Discriminates MHC-Dependent and -Independent Stages of Thymocyte Positive Selection

1999 • 83 citations

Co-stimulation-dependent activation of a JNK-kinase in T lymphocytes

1998 • 77 citations

ZAP-70 and SLP-76 Regulate Protein Kinase C-θ and NF-κB Activation in Response to Engagement of CD3 and CD28

2001 • 74 citations

Adapters in lymphocyte signaling

2002 • 71 citations

Mechanism Responsible for T-Cell Antigen Receptor- and CD28- or Interleukin 1 (IL-1) Receptor-Initiated Regulation of IL-2 Gene Expression by NF-κB

1998 • 67 citations

GRID: A Novel Grb-2-Related Adapter Protein That Interacts with the Activated T Cell Costimulatory Receptor CD28

2000 • 63 citations

Thymocyte activation induces the association of phosphatidylinositol 3‐kinase and pp120 with CD5

1997 • 48 citations

Developmental regulation of the TCR zeta-chain. Differential expression and tyrosine phosphorylation of the TCR zeta-chain in resting immature and mature T lymphocytes.

1994 • 38 citations

Autonomous induction of proliferation, JNK and NF-κB activation in primary resting T cells by mobilized CD28

2000 • 34 citations

Maltose Binding Protein (MBP) Fusion Proteins with Low or No Affinity to Amylose Resins Can Be Single-Step Purified Using a Novel Anti-MBP Monoclonal Antibody

1998 • 23 citations

Detection of pET-Vector Encoded, Recombinant S-Tagged Proteins Using the Monoclonal Antibody ATOM-2

2001 • 7 citations