Requirements for Differentiation of an Immature CD4⁺8⁺ T‐Cell Line

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Cyclosporin A inhibits activation-induced cell death in T-cell hybridomas and thymocytes

1989 • 513 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

A Role for CD5 in TCR-Mediated Signal Transduction and Thymocyte Selection

1995 • 437 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

[40] Use of retroviral vectors for gene transfer and expression

1993 • 412 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Cellular immunity to HIV activated by CD4 fused to T cell or Fc receptor polypeptides

1991 • 391 citations

Failure to synthesize the T Cell CD3-? chain: Structure and function of a partial T cell receptor complex

1988 • 351 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain.

1993 • 318 citations

T-cell and basophil activation through the cytoplasmic tail of T-cell-receptor zeta family proteins.

1991 • 307 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

Molecular Cloning of the Zeta Chain of the T Cell Antigen Receptor

1988 • 275 citations

Signals through T cell receptor-zeta chain alone are insufficient to prime resting T lymphocytes.

1995 • 266 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

The accessory function of murine intercellular adhesion molecule-1 in T lymphocyte activation. Contributions of adhesion and co-activation.

1991 • 197 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Role of CD4 and CD8 in T Cell Activation and Differentiation

1993 • 172 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

1992 • 141 citations

Role of TCR ζ Chain in T Cell Development and Selection

1994 • 141 citations

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement.

1994 • 109 citations

Both T cell receptor (TcR)‐CD3 complex and CD2 increase the tyrosine kinase activity of p56^lck. CD2 can mediate TcR‐CD3‐independent and CD45‐dependent activation of p56^lck

1992 • 91 citations

Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.

1995 • 84 citations

Uptake of extracellular Ca²⁺ and not recruitment from internal stores is essential for T lymphocyte proliferation

1988 • 72 citations

The tyrosine activation motif as a target of protein tyrosine kinases and SH2 domains

1995 • 66 citations

MOLECULAR AND GENETIC INSIGHTS INTO T CELL ANTIGEN RECEPTOR STRUCTURE AND FUNCTION

1991 • 65 citations

Differentiation of an immature T cell line: A model of thymic positive selection

1992 • 63 citations

Differential effects of zeta and eta transgenes on early alpha/beta T cell development.

1994 • 50 citations

Distinct differentiative stages of CD4+CD8+ thymocyte development defined by the lack of coreceptor binding in positive selection.

1995 • 44 citations

Activation of B- and T-cells by the cytoplasmic domains of the B-cell antigen receptor proteins Ig-alpha and Ig-beta.

1994 • 39 citations

Requirement for kinase activity of CD4-associated p56lck in antibody-triggered T cell signal transduction.

1994 • 34 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 33 citations

Use of Retroviral Vectors for Gene Transfer and Expression

1995 • 33 citations

The interaction of CD4 with CD3/Ti regulates tyrosine phosphorylation of substrates during T cell activation.

1990 • 32 citations

Interactions between the tyrosine kinases p56lck, p59fyn and p50csk in CD4 signaling in T cells

1995 • 19 citations

Different cytoplasmic structure of the CD3ζ family dimer modulates the activation signal and function of T cells

1994 • 18 citations

Discrimination between thymic epithelial cells and peripheral antigen-presenting cells in the induction of immature T cell differentiation

1994 • 18 citations

Signals for activation of CD8-dependent adhesion and costimulation in CTLs.

1994 • 16 citations

Contrast between class I and class II MHC-mediated differentiation of a CD4⁺CD8⁺ T cell line: implications for lineage commitment

1995 • 6 citations

Molecular And Genetic Insights Into T Cell Antigen Receptor Structure And Function

1991 • 4 citations