Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.

1995 • 1,739 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS

1999 • 1,309 citations

Two TNF receptors

1992 • 1,048 citations

Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuli.

1995 • 1,010 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cells.

1997 • 780 citations

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappa B that blocks TNFalpha -induced apoptosis

1999 • 721 citations

Coupling of a Signal Response Domain in IκBα to Multiple Pathways for NF-κB Activation

1995 • 706 citations

Inhibition of NF-kappaB/Rel induces apoptosis of murine B cells.

1996 • 604 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

Cytotoxic mechanism of tumor necrosis factor‐α

1990 • 539 citations

IEX -1L, an Apoptosis Inhibitor Involved in NF-κB-Mediated Cell Survival

1998 • 417 citations

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

1994 • 361 citations

Tumor necrosis factor: a potent effector molecule for tumor cell killing by activated macrophages.

1986 • 360 citations

Differential regulation of the c-myc oncogene promoter by the NF-kappa B rel family of transcription factors.

1994 • 280 citations

Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo.

1999 • 265 citations

Constitutive activation of transcription factors NF-?B, AP-1, and NF-IL6 in human head and neck squamous cell carcinoma cell lines that express pro-inflammatory and pro-angiogenic cytokines

1999 • 221 citations

DNA fragmentation: manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphotoxin-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant.

1986 • 152 citations

The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.

1999 • 151 citations

Enhanced degradation of I-kappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells.

1997 • 143 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-κB and Myc/Max

1999 • 124 citations

Epidermal growth factor activation of NF-κB is mediated through IκBα degradation and intracellular free calcium

1998 • 123 citations

Cytotoxic activity of tumor necrosis factor (TNF) on human cancer cells in vitro.

1981 • 113 citations

Induction of TNF-sensitive cellular phenotype by c-Myc involves p53 and impaired NF-kappa B activation

1997 • 113 citations

Regulation of the p53 protein by the MDM2 oncoprotein--thirty-eighth G.H.A. Clowes Memorial Award Lecture.

1999 • 111 citations

Hyperthermic Isolated Limb Perfusion With Tumor Necrosis Factor α, Interferon Gamma, and Melphalan for Locally Advanced Nonmelanoma Skin Tumors of the Extremities

1999 • 108 citations

Repression of NF-κB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators

1999 • 104 citations

Recombinant tumor necrosis factor: Species specificity for a variety of human and murine transformed cell lines

1986 • 100 citations

Differential Regulation of the c-myc Oncogene Promoter by the NF-κB Rel Family of Transcription Factors

1994 • 99 citations

Selective Recognition of the Activated Form of Transcription Factor NF-χB by a Monoclonal Anfibody

1995 • 98 citations

NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-α and Fas ligation: the role of reactive oxygen species

1999 • 88 citations

Constitutive and Cytokine-induced Expression of the Melanoma Growth Stimulatory Activity/GROα Gene Requires Both NF-κB and Novel Constitutive Factors

1995 • 83 citations

Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.

1998 • 79 citations

Modulation with cytokines of radiation injury: suggested mechanisms of action.

1997 • 75 citations

Evaluation of antitumor effect of tumor necrosis factor in terms of protein metabolism and cell cycle kinetics

1993 • 53 citations

Inhibition of nuclear factor-kappaB activation confers sensitivity to tumor necrosis factor-alpha by impairment of cell cycle progression in human glioma cells.

1999 • 53 citations

Selection of macrophage-resistant progressor tumor variants by the normal host. Requirement for concomitant T cell-mediated immunity.

1983 • 51 citations

Antiproliferative Effects of Cytokines on Squamous Cell Carcinoma

1991 • 46 citations

Expression of TNF and the 55‐kDa TNF receptor in epidermis, oral mucosa, lichen planus and squamous cell carcinoma

1996 • 46 citations

Cell cycle-dependent tumor necrosis factor apoptosis.

1996 • 45 citations

Cell cycle specific effects of tumor necrosis factor alpha in monocyte mediated leukemic cell death and the role of beta 2-integrins.

1993 • 27 citations

Enhanced tumor cell expression of tumor necrosis factor receptors in head and neck squamous cell carcinoma

1995 • 22 citations

Modulation with Cytokines of Radiation Injury: Suggested Mechanisms of Action

1997 • 22 citations

Tumor necrosis factor‐alpha production in human head and neck squamous cell carcinoma

1994 • 22 citations

Modulation of Squamous Carcinoma Cell Growth, Morphology, Adhesiveness and Extracellular Matrix Production by Interferon-γ and Tumor Necrosis Factor-α

1990 • 17 citations

IL-1 and TNF-α but no IL-2 Expression is Found in Squamous Cell Carcinomas of the Head and Neck by RT-PCR

1996 • 17 citations

Nuclear factor kappaB cooperates with c-Myc in promoting murine hepatocyte survival in a manner independent of p53 tumor suppressor function.

1999 • 16 citations

Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors

1995 • 13 citations

Cytotoxicity by Tumor Necrosis Factor is Linked with the Cell Cycle But Does Not Require DNA Synthesis

1989 • 12 citations

Serum levels of tumor necrosis factor in squamous cell carcinoma of the head and neck

1994 • 10 citations

Cell cycle specificity of tumor necrosis factor and its receptor

1987 • 10 citations

Tumor Necrosis Factor and Cytotoxic Agents: Effect on Squamous Carcinoma Lines

1990 • 8 citations

Apoptotic Inhibition of Head and Neck Squamous Cell Carcinoma Cells by Tumor Necrosis Factor

1996 • 7 citations

Estimation of tumor necrosis factor-alpha in the diagnosis, the prognosis and the treatment follow-up of oral squamous cell carcinoma.

1998 • 6 citations

The sensitivity of head and neck squamous cell carcinomas to tumor necrosis factor-α

1993 • 5 citations