The host environment promotes the constitutive activation of nuclear factor-kappaB and proinflammatory cytokine expression during metastatic tumor progression of murine squamous cell carcinoma.

THE NF-κB AND IκB PROTEINS: New Discoveries and Insights

1996 • 5,936 citations

TNF- and Cancer Therapy-Induced Apoptosis: Potentiation by Inhibition of NF-κB

1996 • 2,665 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells.

1992 • 1,524 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB

1993 • 1,129 citations

Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation.

1993 • 1,047 citations

Redox Regulation of NF-kappa B Activation

1997 • 852 citations

Constitutive Activation of NF-κB during Progression of Breast Cancer to Hormone-Independent Growth

1997 • 824 citations

Aberrant nuclear factor-kappaB/Rel expression and the pathogenesis of breast cancer.

1997 • 717 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.

1993 • 416 citations

IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor.

1993 • 411 citations

Inhibition of interleukin-8 reduces tumorigenesis of human non-small cell lung cancer in SCID mice.

1996 • 405 citations

Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice.

1994 • 357 citations

A survey of transformation markers in differentiating epidermal cell lines in culture.

1980 • 320 citations

Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors.

1994 • 302 citations

Rel/NF-kappaB/IkappaB proteins and cancer.

1996 • 281 citations

Pro-inflammatory signaling: Last pieces in the NF-κB puzzle?

1998 • 280 citations

Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

1993 • 268 citations

The Platelet-derived Growth Factor-inducible KC Gene Encodes a Secretory Protein Related to Platelet α-Granule Proteins

1989 • 257 citations

NF-IL6 and NF-kappa B in cytokine gene regulation.

1997 • 234 citations

Serum levels of cytokines in patients with colorectal cancer: Possible involvement of interleukin-6 and interleukin-8 in hematogenous metastasis

1994 • 208 citations

Mechanism and biological significance of constitutive expression of MGSA/GRO chemokines in malignant melanoma tumor progression

1997 • 208 citations

Local expression of antiinflammatory cytokines in cancer.

1993 • 198 citations

Inhibitors of both nuclear factor-kappaB and activator protein-1 activation block the neoplastic transformation response.

1997 • 198 citations

Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells.

1997 • 183 citations

Enhanced I kappa B alpha degradation is responsible for constitutive NF-kappa B activity in mature murine B-cell lines.

1994 • 178 citations

Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α

1995 • 173 citations

Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

1999 • 160 citations

Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells

1997 • 157 citations

Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma.

1996 • 156 citations

Interleukin 1 alpha and tumor necrosis factor alpha stimulate autocrine amphiregulin expression and proliferation of human papillomavirus-immortalized and carcinoma-derived cervical epithelial cells.

1995 • 148 citations

Enhanced degradation of I-kappaB alpha contributes to endogenous activation of NF-kappaB in Hs294T melanoma cells.

1997 • 143 citations

Human papillomavirus type 11 E2 proteins repress the homologous E6 promoter by interfering with the binding of host transcription factors to adjacent elements

1994 • 141 citations

Serum interleukin-8 (IL-8) is elevated in patients with metastatic melanoma and correlates with tumour load

1995 • 121 citations

Expression of dominant negative Jun inhibits elevated AP-1 and NF-κB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes

1998 • 115 citations

Two structurally distinct kappa B sequence motifs cooperatively control LPS-induced KC gene transcription in mouse macrophages.

1995 • 103 citations

Cytokine expression by head and neck squamous cell carcinomas

1992 • 99 citations

Interleukin-8 Expression by Head and Neck Squamous Cell Carcinoma

1995 • 99 citations

Enhanced radiosensitivity by inhibition of nuclear factor kappaB activation in human malignant glioma cells

1997 • 94 citations

NF-κB activation and interleukin 6 production in fibroblasts by estrogen receptor-negative breast cancer cell-derived interleukin 1α

1998 • 91 citations

Variable expression of cytokines in human head and neck squamous cell carcinoma cell lines and consistent expression in surgical specimens.

1998 • 88 citations

HMGI(Y) and Sp1 in addition to NF-κB regulate transcription of the MGSA/GROα gene

1995 • 85 citations

Constitutive and Cytokine-induced Expression of the Melanoma Growth Stimulatory Activity/GROα Gene Requires Both NF-κB and Novel Constitutive Factors

1995 • 83 citations

Effects of interleukin-1alpha, interleukin-1 receptor antagonist, and neutralizing antibody on proinflammatory cytokine expression by human squamous cell carcinoma lines.

1998 • 79 citations

The host environment promotes the development of primary and metastatic squamous cell carcinomas that constitutively express proinflammatory cytokines IL-1a, IL-6, GM-CSF, and KC

1998 • 76 citations

Interleukin-6 and interleukin-6 soluble receptor regulate proliferation of normal, human papillomavirus-immortalized, and carcinoma-derived cervical cells in vitro.

1995 • 75 citations

Regulation of IκBβ in WEHI 231 Mature B Cells

1997 • 74 citations

Metastatic variants derived following in vivo tumor progression of an in vitro transformed squamous cell carcinoma line acquire a differential growth advantage requiring tumor-host interaction.

1997 • 52 citations

The Signal Response of IκBα Is Regulated by Transferable N- and C-Terminal Domains

1997 • 46 citations

Down-regulation of NF-κB activity and NF-κB p65 subunit expression by ras and polyoma middle T oncogenes in human colonic Caco-2 cells

1997 • 25 citations