Interaction of Imatinib Mesilate with Human P-Glycoprotein

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 • 1,109 citations

MDR1 P-Glycoprotein Is a Lipid Translocase of Broad Specificity, While MDR3 P-Glycoprotein Specifically Translocates Phosphatidylcholine

1996 • 863 citations

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P‐glycoprotein: Implications for drug delivery and activity in cancer chemotherapy

1995 • 856 citations

Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance

2000 • 789 citations

The multidrug transporter, a double-edged sword.

1988 • 763 citations

Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 • 677 citations

Frequency and Clinical Significance of the Expression of the Multidrug Resistance Proteins MDR1/P-Glycoprotein, MRP1, and LRP in Acute Myeloid Leukemia. A Southwest Oncology Group Study

1999 • 596 citations

Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification

2000 • 511 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.

1996 • 487 citations

Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl–positive cells

2000 • 291 citations

In vitro cytotoxic effects of a tyrosine kinase inhibitor STI571 in combination with commonly used antileukemic agents

2001 • 274 citations

Distribution of STI-571 to the Brain Is Limited by P-Glycoprotein-Mediated Efflux

2002 • 269 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

Overcoming STI571 resistance with the farnesyl transferase inhibitor SCH66336

2002 • 255 citations

Efficacy of STI571, an Abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against Bcr-Abl–positive cells

2000 • 244 citations

Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1

2002 • 209 citations

Pgp and MRP Activities Using Calcein-AM Are Prognostic Factors in Adult Acute Myeloid Leukemia Patients

1998 • 208 citations

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents

2000 • 191 citations

Interaction of Cytochrome P450 3A Inhibitors with P-Glycoprotein

2002 • 137 citations

Inhibition of multidrug resistance-associated protein (MRP) functional activity with pluronic block copolymers.

1999 • 124 citations

Chronic myelogenous leukemia

2001 • 90 citations

HER (erbB) tyrosine kinase inhibitors in the treatment of breast cancer

2002 • 82 citations

Mechanism of action of rituximab.

2001 • 79 citations

The farnesyl protein transferase inhibitor SCH66336 is a potent inhibitor of MDR1 product P-glycoprotein.

2001 • 62 citations

Microfluorometric Evaluation of Calcein Acetoxymethyl Ester as a Probe for P-Glycoprotein-Mediated Resistance: Effects of Cyclosporin A and Its Nonimmunosuppressive Analogue SDZ PSC 833

1994 • 57 citations

Targeted therapies in the treatment of Philadelphia chromosome–positive acute lymphoblastic leukemia

2002 • 47 citations

Tyrosine kinase inhibitors: A clinical perspective

2002 • 38 citations

Gleevec does not cross blood–brain barrier

2003 • 35 citations

Anti-CD19 antibodies inhibit the function of the P-gp pump in multidrug-resistant B lymphoma cells.

1999 • 32 citations

Bromocriptine Reverses P‐Glycoprotein‐mediated Multidrug Resistance in Tumor Cells

2002 • 26 citations

Sequential gene expression of P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP) and lung resistance protein: functional activity of P-gp and MRP present in the doxorubicin-resistant human K562 cell lines

2001 • 26 citations

Epidemiology of the acquired immunodeficiency syndrome (AIDS) in the United States.

1984 • 23 citations

Increase in the Level of P‐Glycoprotein mRNA Expression in Multidrug‐resistant K562 Cell Lines Treated with Sodium Butyrate Is Not Accompanied with Erythroid Differentiation

1990 • 11 citations