Pgp and MRP Activities Using Calcein-AM Are Prognostic Factors in Adult Acute Myeloid Leukemia Patients

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Proposed Revised Criteria for the Classification of Acute Myeloid Leukemia

1985 • 2,981 citations

Acute Myeloid Leukemia in the Elderly: Assessment of Multidrug Resistance (MDR1) and Cytogenetics Distinguishes Biologic Subgroups With Remarkably Distinct Responses to Standard Chemotherapy. A Southwest Oncology Group Study

1997 • 897 citations

A Southwest Oncology Group study

1993 • 778 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

The drug resistance-related protein LRP is the human major vault protein

1995 • 621 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations

1981 • 507 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

1993 • 496 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Multidrug resistance (mdr1) gene expression in adult acute leukemias: correlations with treatment outcome and in vitro drug sensitivity

1991 • 407 citations

Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.

1996 • 398 citations

Calcein accumulation as a fluorometric functional assay of the multidrug transporter

1994 • 316 citations

Molecular and Cellular Biology of Multidrug Resistance in Tumor Cells

1991 • 281 citations

Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia

1996 • 254 citations

Correlation of multidrug resistance (MDR1) protein expression with functional dye/drug efflux in acute myeloid leukemia by multiparameter flow cytometry: identification of discordant MDR-/efflux+ and MDR1+/efflux- cases

1995 • 229 citations

ATP‐dependent efflux of calcein by the multidrug resistance protein (MRP): no inhibition by intracellular glutathione depletion

1995 • 196 citations

Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cells

1996 • 194 citations

Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia

1995 • 182 citations

Predominance of functional multidrug resistance (MDR-1) phenotype in CD34+ acute myeloid leukemia cells

1993 • 164 citations

Functional detection of MDR1/P170 and MRP/P190-mediated multidrug resistance in tumour cells by flow cytometry

1995 • 151 citations

Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines.

1995 • 123 citations

Expression of multidrug resistance-associated protein (MRP) and multidrug resistance (MDR1) genes in acute myeloid leukemia.

1995 • 115 citations

Probenecid reverses multidrug resistance in multidrug resistance-associated protein-overexpressing HL60/AR and H69/AR cells but not in P-glycoprotein-overexpressing HL60/Tax and P388/ADR cells

1997 • 106 citations

A new method for quantitative assessment of P-glycoprotein-related multidrug resistance in tumour cells

1996 • 101 citations

Quality control of multidrug resistance assays in adult acute leukemia: correlation between assays for P-glycoprotein expression and activity

1996 • 98 citations

Multicentric evaluation of the MDR phenotype in leukemia

1997 • 88 citations

Multidrug resistance-associated protein: A protein distinct from P-glycoprotein involved in cytotoxic drug expulsion

1997 • 78 citations

P‐glycoprotein (PGP) and lung resistance‐related protein (LRP) expression and function in leukaemic blast cells

1997 • 71 citations

Expression of the multidrug resistance‐associated protein (MRP) mRNA and protein in normal peripheral blood and bone marrow haemopoietic cells

1996 • 61 citations

Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment

1997 • 60 citations

Sequential emergence ofMRP- andMDR1-gene over-expression as well asMDR1-gene translocation in homoharringtonine-selected K562 human leukemia cell lines

1996 • 60 citations

Flow cytometric determination of the multidrug‐resistant phenotype in acute leukemia

1994 • 44 citations

Quantitative Estimation of MDR1 mRNA Levels by Polymerase Chain Reaction

1991 • 14 citations

Effects of Amiodarone on Ouabain Binding to Microsomal Na+, K+-ATPase in Guinea-Pig Heart Preparations

1997 • 13 citations