Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

1996 • 3,649 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Induction of Chronic Myelogenous Leukemia in Mice by the P210 ^bcr/abl Gene of the Philadelphia Chromosome

1990 • 2,207 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Tyrosine Kinase Activity and Transformation Potency of bcr-abl Oncogene Products

1990 • 1,305 citations

Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.

1996 • 1,080 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells

1997 • 646 citations

Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein.

1988 • 602 citations

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

1997 • 527 citations

Clinical significance of multidrug resistance P-glycoprotein expression on acute nonlymphoblastic leukemia cells at diagnosis [see comments]

1992 • 507 citations

CGP 57148, a Tyrosine Kinase Inhibitor, Inhibits the Growth of Cells Expressing BCR-ABL, TEL-ABL, and TEL-PDGFR Fusion Proteins

1997 • 438 citations

In Vivo Eradication of Human BCR/ABL-Positive Leukemia Cells With an ABL Kinase Inhibitor

1999 • 388 citations

Inhibition of the ABL Kinase Activity Blocks the Proliferation of BCR/ABL+Leukemic Cells and Induces Apoptosis

1997 • 325 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 231 citations

Correlation between leukemic cell retention of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate and response to therapy.

1979 • 188 citations

Chromosome Abnormalities in Malignant Hematologic Diseases

1982 • 180 citations

Clinical significance of P-glycoprotein in multidrug resistance malignancies [editorial] [see comments]

1993 • 172 citations

Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression

1995 • 165 citations

Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies

1999 • 151 citations

Selective induction of apoptosis in Philadelphia chromosome-positive chronic myelogenous leukemia cells by an inhibitor of BCR–ABL tyrosine kinase, CGP 57148

1998 • 134 citations

Tyrphostin-induced inhibition of p210bcr-abl tyrosine kinase activity induces K562 to differentiate

1993 • 133 citations

A temperature sensitive p210 BCR-ABL mutant defines the primary consequences of BCR-ABL tyrosine kinase expression in growth factor dependent cells.

1994 • 117 citations

Expression of the multidrug resistance-associated protein (MRP) in acute leukaemia.

1994 • 103 citations

Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis

1990 • 92 citations

Effect of herbimycin A, an antagonist of tyrosine kinase, on bcr/abl oncoprotein-associated cell proliferations: abrogative effect on the transformation of murine hematopoietic cells by transfection of a retroviral vector expressing oncoprotein P210bcr/abl and preferential inhibition on Ph1-positive leukemia cell growth

1992 • 75 citations

Increased mdr gene expression and decreased drug accumulation in multidrug-resistant human melanoma cells.

1988 • 75 citations

Extensive amplification of bcr/abl fusion genes clustered on three marker chromosomes in human leukemic cell line K-562.

1995 • 71 citations

Relation between the human fibroblast strain 46BR and cell lines representative of Bloom's syndrome.

1988 • 60 citations

Nucleotide sequence analysis of human abl and bcr-abl cDNAs.

1989 • 56 citations

Bcr: a negative regulator of the Bcr-Abl oncoprotein

1999 • 40 citations

Inhibition of chronic myelogenous leukemia cells harboring a BCR-ABL B3A2 junction by antisense oligonucleotides targeted at the B2A2 junction.

1995 • 33 citations

Unique organization of the human BCR gene promoter

1990 • 32 citations

Characterization of the BCR Promoter in Philadelphia Chromosome-Positive and -Negative Cell Lines

1991 • 31 citations

Differences in uptake of adriamycin and daunomycin by normal BM cells and acute leukemia cells determined by flow cytometry

1981 • 24 citations

Correlation between the proportion of Philadelphia chromosome‐positive metaphase cells and levels of BCR‐ABL mRNA in chronic myeloid leukaemia

1995 • 23 citations

Bcr-abl translocation can occur during the induction of multidrug resistance and confers apoptosis resistance on myeloid leukemic cell lines

1997 • 22 citations

Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines.

1991 • 21 citations

Reversal of multidrug resistance in hematological malignancies

1999 • 20 citations