Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor

1986 • 2,416 citations

Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension

1990 • 2,388 citations

Vitamin E Consumption and the Risk of Coronary Heart Disease in Men

1993 • 2,363 citations

Vitamin E Consumption and the Risk of Coronary Disease in Women

1993 • 2,158 citations

Regulatory Functions of the Vascular Endothelium

1990 • 1,899 citations

Ascorbate is an outstanding antioxidant in human blood plasma.

1989 • 1,876 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor

1986 • 1,211 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 • 1,066 citations

Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus

1996 • 1,024 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.

1996 • 884 citations

Angiotensin II induces smooth muscle cell proliferation in the normal and injured rat arterial wall.

1991 • 751 citations

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

1993 • 685 citations

Superoxide and peroxynitrite inatherosclerosis.

1994 • 674 citations

The antioxidant role of vitamin C

1986 • 660 citations

Modulation of Vascular Smooth Muscle Contraction by the Endothelium

1986 • 643 citations

Ascorbic Acid Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1996 • 593 citations

Impairment of endothelium-dependent dilation is an early event in children with familial hypercholesterolemia and is related to the lipoprotein(a) level.

1994 • 590 citations

Antioxidant Vitamin C Improves Endothelial Dysfunction in Chronic Smokers

1996 • 563 citations

Endothelial dysfunction of the coronary microvasculature is associated with coronary blood flow regulation in patients with early atherosclerosis.

1991 • 531 citations

Long-term Cigarette Smoking Impairs Endothelium-Dependent Coronary Arterial Vasodilator Function

1995 • 496 citations

The redox couple between glutathione and ascorbic acid: A chemical and physiological perspective

1994 • 487 citations

Inactivation of endothelial derived relaxing factor by oxidized lipoproteins.

1992 • 452 citations

Flow-dependent coronary artery dilatation in humans.

1989 • 333 citations

Role of Superoxide in the Depressed Nitric Oxide Production by the Endothelium of Genetically Hypertensive Rats

1995 • 304 citations

Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells

1996 • 294 citations

Different Mechanisms of Endothelial Dysfunction With Aging and Hypertension in Rat Aorta

1995 • 287 citations

Loss of selective endothelial cell vasoactive functions caused by hypercholesterolemia in pig coronary arteries.

1988 • 265 citations

Endothelin stimulated by angiotensin II augments contractility of spontaneously hypertensive rat resistance arteries.

1992 • 264 citations

Effects of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension.

1988 • 220 citations

Endothelium-Dependent Coronary Vasomotion Relates to the Susceptibility of LDL to Oxidation in Humans

1996 • 199 citations

Impaired Endothelium-Dependent Vasodilation of Large Epicardial and Resistance Coronary Arteries in Patients With Essential Hypertension

1995 • 191 citations

Epicardial coronary artery responses to acetylcholine are impaired in hypertensive patients.

1992 • 173 citations

Effect of antioxidant vitamins on low density lipoprotein oxidation and impaired endothelium-dependent vasodilation in patients with hypercholesterolemia

1994 • 173 citations

Effects of <scp>l</scp> -Arginine Supplementation on Endothelium-Dependent Coronary Vasodilation in Patients With Angina Pectoris and Normal Coronary Arteriograms

1996 • 149 citations

Angiotensin converting enzyme inhibition prevents the increase in aortic collagen in rats.

1994 • 140 citations

Pressure and Angiotensin II Synergistically Induce Aortic Fibronectin Expression in Organ Culture Model of Rabbit Aorta

1996 • 115 citations

Vitamin E Deficiency in Variant Angina

1996 • 96 citations

Decreased Superoxide Dismutase Activity and Increased Superoxide Anion Production in Cardiac Hypertrophy of Spontaneously Hypertensive Rats

1995 • 71 citations

Low Plasma Vitamins E and C Increased Risk of Angina in Scottish Men^a

1989 • 66 citations

Effect of Copper-Zinc Superoxide Dismutase on Endothelium-Dependent Vasodilation in Patients With Essential Hypertension

1995 • 59 citations

Vascular responses to leukocyte products in atherosclerotic primates.

1989 • 55 citations

Normal Superoxide Dismutase (SOD) Gene in Pregnancy-Induced Hypertension: Is the Decreased Sod Activity a Secondary Phenomenon?

1994 • 22 citations

Nitric Oxide and Superoxide Anions in Vascular Reactivity of Renovascular Hypertensive Rats

1995 • 21 citations