Endothelial Function and Oxidant Stress

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells.

1994 • 2,753 citations

Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone.

1996 • 2,456 citations

Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.

1989 • 2,183 citations

Hypercholesterolemia increases endothelial superoxide anion production.

1993 • 1,799 citations

Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure

1993 • 1,775 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

1988 • 1,024 citations

Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension

1997 • 831 citations

Eicosonoid metabolism and beta-adrenergic mechanisms in coronary arterial smooth muscle: potential compartmentation of cAMP

1986 • 795 citations

Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase.

1992 • 748 citations

Association of the Renin-Sodium Profile with the Risk of Myocardial Infarction in Patients with Hypertension

1991 • 734 citations

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

1995 • 660 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress

1995 • 572 citations

NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium

1994 • 546 citations

Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta.

1990 • 527 citations

Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells.

1986 • 516 citations

Superoxide radical and superoxide dismutase

1972 • 469 citations

Oxygen-derived free radicals, endothelium, and responsiveness of vascular smooth muscle

1986 • 380 citations

Circulating plasma xanthine oxidase contributes to vascular dysfunction in hypercholesterolemic rabbits.

1996 • 375 citations

Release of intact endothelium-derived relaxing factor depends on endothelial superoxide dismutase activity

1991 • 322 citations

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

1996 • 312 citations

An NADPH oxidase superoxide-generating system in the rabbit aorta

1995 • 295 citations

Shear Stress Modulates Expression of Cu/Zn Superoxide Dismutase in Human Aortic Endothelial Cells

1996 • 294 citations

Oxygen radicals as second messengers for expression of the monocyte chemoattractant protein, JE/MCP-1, and the monocyte colony-stimulating factor, CSF-1, in response to tumor necrosis factor-alpha and immunoglobulin G. Evidence for involvement of reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent oxidase.

1993 • 275 citations

NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system.

1987 • 266 citations

Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide‐Dependent Cerebral Injury^a

1994 • 215 citations

Kinetics of Cytochrome C2+ Oxidation by Peroxynitrite: Implications for Superoxide Measurements in Nitric Oxide-Producing Biological-Systems

1995 • 188 citations

Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets

1987 • 181 citations

Superoxide Radical and Superoxide Dismutases: Threat and Defense

1980 • 178 citations

Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle

1994 • 165 citations

Prevention of tolerance to hemodynamic effects of nitrates with concomitant use of hydralazine in patients with chronic heart failure

1995 • 140 citations

Modulation of endothelium-dependent responses by chronic alterations of blood flow

1986 • 134 citations

Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor

1994 • 127 citations

Xanthine Oxidase Binding to Glycosaminoglycans: Kinetics and Superoxide Dismutase Interactions of Immobilized Xanthine Oxidase–Heparin Complexes

1997 • 117 citations

Cytochrome b-558 α-subunit cloning and expression in rat aortic smooth muscle cells

1995 • 110 citations

Free radical modification of lipoproteins and cholesterol accumulation in cells upon atherosclerosis

1991 • 93 citations

Posttranscriptional regulation of macrophage tissue factor expression by antioxidants

1995 • 80 citations

A prospective, in vivo study of the relationship between blood flow hemodynamics and atherosclerosis in a hyperlipidemic swine model

1994 • 55 citations

Nitric oxide in the pathogenesis of hypertension

1995 • 33 citations

Role of cytochrome b-559 in arachidonic acid activation of resting human neutrophils

1988 • 4 citations