Hsp90 Is Essential for the Synthesis and Subsequent Membrane Association, But Not the Maintenance, of the Src-Kinase p56lck

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Identification and Structural Characterization of the ATP/ADP-Binding Site in the Hsp90 Molecular Chaperone

1997 • 1,235 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Structural Basis for Inhibition of the Hsp90 Molecular Chaperone by the Antitumor Antibiotics Radicicol and Geldanamycin

1999 • 979 citations

The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes.

1988 • 716 citations

Myristylation and palmitylation of Src family members: The fats of the matter

1994 • 694 citations

The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor.

1993 • 652 citations

Hsp90 & Co. – a holding for folding

1999 • 631 citations

Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs

1990 • 629 citations

The when and how of Src regulation

1993 • 543 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Lipid Modifications of Trimeric G Proteins

1995 • 468 citations

Polyubiquitination and Proteasomal Degradation of the p185c-B-2 Receptor Protein-tyrosine Kinase Induced by Geldanamycin

1996 • 460 citations

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

1995 • 454 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin

1998 • 396 citations

Perturbation of Hsp90 interaction with nascent CFTR prevents its maturation and accelerates its degradation by the proteasome

1998 • 367 citations

S-acylation of LCK protein tyrosine kinase is essential for its signalling function in T lymphocytes

1997 • 364 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

The dynamic role of palmitoylation in signal transduction

1995 • 315 citations

Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol

1998 • 272 citations

Palmitylation of an amino-terminal cysteine motif of protein tyrosine kinases p56lck and p59fyn mediates interaction with glycosyl-phosphatidylinositol-anchored proteins.

1993 • 259 citations

p185erbB2 Binds to GRP94 in Vivo

1996 • 259 citations

Short Related Sequences in the Cytoplasmic Domains of CD4 and CD8 Mediate Binding to the Amino-Terminal Domain of the p56^lck Tyrosine Protein Kinase

1990 • 245 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome

1997 • 193 citations

Rapid Plasma Membrane Anchoring of Newly Synthesized p59 fyn: Selective Requirement for NH2-Terminal Myristoylation and Palmitoylation at Cysteine-3

1997 • 186 citations

Maturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90

1999 • 182 citations

Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus.

1991 • 165 citations

Transit of pp60v-src to the plasma membrane.

1982 • 165 citations

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

1983 • 162 citations

Reversible palmitoylation of the protein-tyrosine kinase p56lck.

1993 • 159 citations

New Insights into the Interaction of Ras with the Plasma Membrane

1999 • 154 citations

Understanding covalent modifications of proteins by lipids: where cell biology and biophysics mingle

1997 • 147 citations

Geldanamycin, a Heat Shock Protein 90-Binding Benzoquinone Ansamycin, Inhibits Steroid-Dependent Translocation of the Glucocorticoid Receptor from the Cytoplasm to the Nucleus

1997 • 146 citations

Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase.

1990 • 145 citations

The protein tyrosine kinase p56lck inhibits CD4 endocytosis by preventing entry of CD4 into coated pits

1992 • 141 citations

Retargeting of cytosolic proteins to the plasma membrane by the Lck protein tyrosine kinase dual acylation motif

1997 • 136 citations

Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo

1997 • 127 citations

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus

1981 • 110 citations

Association of the heat shock protein HSP90 with steroid hormone receptors and tyrosine kinase oncogene products

1986 • 110 citations

A 50-kDa cytosolic protein complexed with the 90-kDa heat shock protein (hsp90) is the same protein complexed with pp60v-src hsp90 in cells transformed by the Rous sarcoma virus.

1991 • 101 citations

Palmitoylation of Either Cys-3 or Cys-5 Is Required for the Biological Activity of the Lck Tyrosine Protein Kinase

1995 • 98 citations

Reconstitution of the multiprotein complex of pp60src, hsp90, and p50 in a cell-free system.

1992 • 93 citations

Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

1994 • 93 citations

Lysine residues form an integral component of a novel NH2-terminal membrane targeting motif for myristylated pp60v-src.

1992 • 91 citations

Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.

1983 • 88 citations

Intrinsic Signals in the Unique Domain Target p56lckto the Plasma Membrane Independently of CD4

1997 • 84 citations

src-related protein tyrosine kinases and their surface receptors

1993 • 84 citations

A 50 Kilodalton Protein Associated with Raf and pp60^v-src Protein Kinases Is a Mammalian Homolog of the Cell Cycle Control Protein cdc37

1997 • 70 citations

Analysis of the activity and phosphorylation of the lck protein in lymphoid cells.

1989 • 68 citations

Palmitylation of an Amino-Terminal Cysteine Motif of Protein Tyrosine Kinases p56^lckand p59^fynMediates Interaction With Glycosyl-Phosphatidylinositol-Anchored Proteins

1993 • 66 citations

Hsp90-Mediated Folding of the Lymphoid Cell Kinase p56^lck

1996 • 66 citations

Trafficking of an Acylated Cytosolic Protein: Newly Synthesized p56lck Travels to the Plasma Membrane via the Exocytic Pathway

1999 • 59 citations

The structure of the μ/pseudo light chain complex on human pre‐B cells is consistent with a function in signal transduction

1993 • 56 citations

Modular Folding and Evidence for Phosphorylation-induced Stabilization of an hsp90-dependent Kinase

1998 • 51 citations

Amino-Terminal Palmitate or Polybasic Domain Can Provide Required Second Signal to Myristate for Membrane Binding of P56lck

1995 • 47 citations

Hematopoietic Cells Express Two Forms of lyn Kinase Differing by 21 Amino Acids in the Amino Terminus

1991 • 39 citations

Stimulation of Phosphorylation of Tyr394 by Hydrogen Peroxide Reactivates Biologically Inactive, Non-membrane-bound Forms of Lck

1996 • 30 citations

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