Modular Folding and Evidence for Phosphorylation-induced Stabilization of an hsp90-dependent Kinase

Protein folding in the cell

1992 • 4,138 citations

Molecular chaperones in cellular protein folding

1996 • 3,540 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation.

1994 • 1,426 citations

Three-dimensional structure of the tyrosine kinase c-Src

1997 • 1,402 citations

Regulation, substrates and functions of src

1996 • 1,173 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Binding of SH2 Domains of Phospholipase Cγ1, GAP, and Src to Activated Growth Factor Receptors

1990 • 608 citations

Heat‐shock proteins as molecular chaperones

1994 • 551 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Src homology region 2 domains direct protein-protein interactions in signal transduction.

1990 • 498 citations

Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4.

1996 • 475 citations

Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum

1994 • 430 citations

Heat-shock protein hsp90 governs the activity of pp60v-src kinase.

1993 • 420 citations

Hormone and antihormone induce distinct conformational changes which are central to steroid receptor activation.

1992 • 363 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Progesterone Receptor Structure and Function Altered by Geldanamycin, an hsp90-Binding Agent

1995 • 291 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells.

1996 • 259 citations

Inhibition of progesterone receptor activation by sodium molybdate

1980 • 257 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

Ribosome‐mediated translational pause and protein domain organization

1996 • 241 citations

A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor

1996 • 240 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Binding of p23 and hsp90 during assembly with the progesterone receptor.

1995 • 224 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

Glucocorticoid receptor inactivation under cell-free conditions.

1977 • 196 citations

Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.

1991 • 175 citations

Transit of pp60v-src to the plasma membrane.

1982 • 165 citations

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

1983 • 162 citations

The general concept of molecular chaperones

1993 • 140 citations

Synthesis of phosphotyrosine-containing peptides and their use as substrates for protein tyrosine phosphatases

1993 • 101 citations

Association of Hsp90 with Cellular Src-Family Kinases in a Cell-Free System Correlates with Altered Kinase Structure and Function

1994 • 93 citations

Hsp90 Is Obligatory for the Heme-regulated eIF-2α Kinase to Acquire and Maintain an Activable Conformation

1997 • 85 citations

The lymphocyte‐specific protein tyrosine kinase p56^lck is hyperphosphorylated on serine and tyrosine residues within minutes after activation via T cell receptor or CD2

1989 • 80 citations

Effect of Geldanamycin on the Kinetics of Chaperone-Mediated Renaturation of Firefly Luciferase in Rabbit Reticulocyte Lysate

1996 • 77 citations

The Basic Helix-Loop-Helix/PAS Factor Sim Is Associated with hsp90:

1995 • 76 citations

Quasi-native Chaperonin-bound Intermediates in Facilitated Protein Folding

1995 • 66 citations

Hsp90-Mediated Folding of the Lymphoid Cell Kinase p56^lck

1996 • 66 citations

A function for the lck proto-oncogene

1989 • 57 citations

Src homology domains of v-Src stabilize an active conformation of the tyrosine kinase catalytic domain

1996 • 19 citations

Phosphopeptide occupancy and photoaffinity cross-linking of the v-Src SH2 domain attenuates tyrosine kinase activity.

1994 • 14 citations

In vitro association of the phosphatidylinositol 3‐kinase regulatory subunit (p85) with the human insulin receptor

1995 • 5 citations

19-Allylaminoherbimycin A, an analog of herbimycin A that is stable against treatment with thiol compounds or granulocyte-macrophage colony-stimulating factor in human leukemia cells

1995 • 3 citations