In Vivo Administration of Leptin Activates Signal Transduction Directly in Insulin-Sensitive Tissues: Overlapping but Distinct Pathways from Insulin

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1995 • 5,143 citations

STATs and Gene Regulation

1997 • 3,927 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Abnormal splicing of the leptin receptor in diabetic mice

1996 • 2,361 citations

Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression

1998 • 2,143 citations

The insulin signaling system.

1994 • 1,733 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Identification of targets of leptin action in rat hypothalamus.

1996 • 1,502 citations

Cytokine signal transduction

1994 • 1,358 citations

Leptin enters the brain by a saturable system independent of insulin

1996 • 1,210 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice

1996 • 1,097 citations

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

1999 • 1,040 citations

Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

1998 • 1,000 citations

Divergent Signaling Capacities of the Long and Short Isoforms of the Leptin Receptor

1997 • 907 citations

The Relation between Insulin Sensitivity and the Fatty-Acid Composition of Skeletal-Muscle Phospholipids

1993 • 839 citations

The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors.

1996 • 820 citations

Defective STAT signaling by the leptin receptor in diabetic mice.

1996 • 803 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Modulation of Insulin Activities by Leptin

1996 • 733 citations

Acute stimulation of glucose metabolism in mice by leptin treatment

1997 • 717 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction

1996 • 629 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

A role for leptin and its cognate receptor in hematopoiesis

1996 • 478 citations

Leptin Impairs Metabolic Actions of Insulin in Isolated Rat Adipocytes

1997 • 463 citations

Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.

1995 • 436 citations

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

1997 • 384 citations

Direct effects of leptin on brown and white adipose tissue.

1997 • 377 citations

Human blood-brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels.

1997 • 374 citations

Obese Gene Expression Alters the Ability of 30A5 Preadipocytes to Respond to Lipogenic Hormones

1996 • 238 citations

Leptin Action in Intestinal Cells

1998 • 237 citations

Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice

1996 • 232 citations

Intracerebroventricular Leptin Regulates Hepatic but Not Peripheral Glucose Fluxes

1998 • 229 citations

A Short Form of Leptin Receptor Performs Signal Transduction

1997 • 211 citations

Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways

1997 • 204 citations

Experimental Obesity: A Homeostatic Failure due to Defective Nutrient Stimulation of the Sympathetic Nervous System

1989 • 201 citations

Leptin is cleared from the circulation primarily by the kidney.

1996 • 171 citations

Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion

1997 • 134 citations

Recombinant OB-Gene Product Reduces Food-Intake in Fasted Mice

1995 • 117 citations

Effects of Leptin on Insulin Sensitivity in Normal Rats

1997 • 104 citations

Leptin directly alters lipid partitioning in skeletal muscle

1997 • 100 citations

Reflections on STAT3, STAT5, and STAT6 as fat STATs.

1996 • 96 citations

The Leptin Receptor Mediates Apparent Autocrine Regulation of Leptin Gene Expression

1997 • 84 citations

Insulin Stimulates the Serine Phosphorylation of the Signal Transducer and Activator of Transcription (STAT3) Isoform

1996 • 73 citations

The Leptin Receptor Activates Janus Kinase 2 and Signals for Proliferation in a Factor-Dependent Cell Line

1997 • 66 citations

Potential Role of Protein Kinase B in Glucose Transporter 4 Translocation in Adipocytes

1997 • 55 citations

Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells

1996 • 46 citations

Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization.

1997 • 29 citations

Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes

1998 • 29 citations

Lack of Effect of Leptin on Glucose Transport, Lipoprotein Lipase, and Insulin Action in Adipose and Muscle Cells

1998 • 23 citations