Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcmeurin and phosphatase‐2A

Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology.

1986 • 3,430 citations

THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASES

1989 • 2,518 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 • 759 citations

Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

1986 • 729 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

The Primary Structure and Heterogeneity of Tau Protein from Mouse Brain

1988 • 671 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

Microtubule-Associated Protein MAP2 Shares a Microtubule Binding Motif with Tau Protein

1988 • 476 citations

Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5

1993 • 470 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Glycogen synthase kinase 3β is identical to tau protein kinase I generating several epitopes of paired helical filaments

1993 • 397 citations

Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles.

1990 • 298 citations

Alzheimer's disease: a cell biological perspective

1992 • 274 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

[33] Classification of protein- serine/threonine phosphatases: identification and quantitation in cell extracts

1991 • 223 citations

The Alzheimer‐like phosphorylation of tau protein reduces microtubule binding and involves Ser‐Pro and Thr‐Pro motifs

1992 • 210 citations

Phosphorylation of recombinant tau by cAMP-dependent protein kinase. Identification of phosphorylation sites and effect on microtubule assembly.

1993 • 198 citations

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease

1992 • 190 citations

Dephosphorylation of Microtubule‐Associated Protein 2, τ Factor, and Tubulin by Calcineurin

1985 • 173 citations

Microtubule-associated protein tau is phosphorylated by protein kinase C on its tubulin binding domain.

1992 • 171 citations

Microtubule assembly using the microtubule‐associated protein MAP‐2 prepared in defined states of phosphorylation with protein kinase and phosphatase

1983 • 163 citations

Proline-directed phosphorylation of human Tau protein.

1992 • 162 citations

Phosphorylation-dependent epitopes of neurofilament antibodies on tau protein and relationship with Alzheimer tau.

1992 • 157 citations

Calcineurin

1988 • 132 citations

Tau as a marker for Alzheimer's disease

1993 • 127 citations

The disordered neuronal cytoskeleton in Alzheimer's disease

1992 • 124 citations

Purification and properties of polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscle.

1987 • 113 citations

Specificity of the polycation‐stimulated (type‐2A) and ATP, Mg‐dependent (type‐1) protein phosphatases toward substrates phosphorylated by P34^cdc2 kinase

1992 • 104 citations

Okadaic acid induces hyperphosphorylated forms of tau protein in human brain slices

1993 • 80 citations

Synthetic peptides as model substrates for the study of the specificity of the polycation‐stimulated protein phosphatases

1990 • 72 citations

Dephosphorylation of r Factor by Protein Phosphatase 2A in Synaptosomal Cytosol Fractions, and Inhibition by Aluminum

1990 • 72 citations

[34] Preparation of low-molecular -weight forms of rabbit muscle protein phosphatase

1988 • 72 citations

Serine/threonine phosphatases in the nervous system

1991 • 64 citations

Locations and immunoreactivities of phosphorylation sites on bovine and porcine tau proteins and a PHF-tau fragment

1993 • 23 citations