Antiviral therapy: current concepts and practices

Virus interference. I. The interferon

1957 • 3,331 citations

The Efficacy of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 3,000 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro.

1985 • 1,830 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Treatment of Chronic Hepatitis C with Recombinant Interferon Alfa

1989 • 1,658 citations

Abnormalities of B-Cell Activation and Immunoregulation in Patients with the Acquired Immunodeficiency Syndrome

1983 • 1,625 citations

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 • 1,574 citations

Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine

1977 • 1,565 citations

Structure of a human common cold virus and functional relationship to other picornaviruses

1985 • 1,419 citations

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

1986 • 1,348 citations

Zidovudine in Asymptomatic Human Immunodeficiency Virus Infection

1990 • 1,288 citations

Recombinant Interferon Alfa Therapy for Chronic Hepatitis C

1989 • 1,233 citations

Multiple Mutations in HIV-1 Reverse Transcriptase Confer High-Level Resistance to Zidovudine (AZT)

1989 • 1,199 citations

Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

1988 • 1,151 citations

9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

1978 • 1,136 citations

The Toxicity of Azidothymidine (AZT) in the Treatment of Patients with AIDS and AIDS-Related Complex

1987 • 1,134 citations

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides.

1986 • 1,032 citations

Broad-Spectrum Antiviral Activity of Virazole: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

1972 • 967 citations

Lassa Fever

1986 • 955 citations

Rational Design of Peptide-Based HIV Proteinase Inhibitors

1990 • 910 citations

Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis

1986 • 873 citations

A Randomized, Controlled Trial of Interferon Alfa-2b Alone and after Prednisone Withdrawal for the Treatment of Chronic Hepatitis B

1990 • 855 citations

Mitochondrial Myopathy Caused by Long-Term Zidovudine Therapy

1990 • 845 citations

The molecular basis of the specific anti-influenza action of amantadine.

1985 • 800 citations

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

1990 • 749 citations

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

1990 • 740 citations

Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis

1977 • 691 citations

A Randomized, Controlled Trial of Prophylactic Ganciclovir for Cytomegalovirus Pulmonary Infection in Recipients of Allogeneic Bone Marrow Transplants

1991 • 640 citations

Effect of Recombinant Human Granulocyte–Macrophage Colony-Stimulating Factor on Myelopoiesis in the Acquired Immunodeficiency Syndrome

1987 • 633 citations

Allogeneic Bone‐Marrow Transplantation

1983 • 614 citations

Designing CD4 immunoadhesins for AIDS therapy

1989 • 612 citations

Early Treatment with Ganciclovir to Prevent Cytomegalovirus Disease after Allogeneic Bone Marrow Transplantation

1991 • 608 citations

Comparative Efficacy of Antiherpes Drugs against Different Strains of Herpes Simplex Virus

1980 • 603 citations

The Safety and Efficacy of Zidovudine (AZT) in the Treatment of Subjects with Mildly Symptomatic Human Immunodeficiency Virus Type 1 (HIV) Infection

1990 • 598 citations

Acyclovir Prophylaxis of Herpes-Simplex-Virus Infections

1981 • 593 citations

ACYCLOVIR VERSUS VIDARABINE IN HERPES SIMPLEX ENCEPHALITIS

1984 • 578 citations

Use of Cytomegalovirus Immune Globulin to Prevent Cytomegalovirus Disease in Renal-Transplant Recipients

1987 • 576 citations

Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.

1978 • 560 citations

Treatment of Cytomegalovirus Pneumonia with Ganciclovir and Intravenous Cytomegalovirus Immunoglobulin in Patients with Bone Marrow Transplants

1988 • 550 citations

A Randomized, Placebo-Controlled Trial of Oral Acyclovir for the Prevention of Cytomegalovirus Disease in Recipients of Renal Allografts

1989 • 548 citations

Aerosolized Ribavirin Treatment of Infants with Respiratory Syncytial Viral Infection

1983 • 542 citations

Cytomegalovirus Immune Globulin and Seronegative Blood Products to Prevent Primary Cytomegalovirus Infection after Marrow Transplantation

1986 • 528 citations

Design, Activity, and 2.8 Å Crystal Structure of a C ₂ Symmetric Inhibitor Complexed to HIV-1 Protease

1990 • 524 citations

Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions

1988 • 513 citations

PHASE I STUDIES OF 2',3'-DIDEOXYCYTIDINE IN SEVERE HUMAN IMMUNODEFICIENCY VIRUS INFECTION AS A SINGLE AGENT AND ALTERNATING WITH ZIDOVUDINE (AZT)

1988 • 513 citations

Recombinant Granulocyte-Macrophage Colony-Stimulating Factor after Autologous Bone Marrow Transplantation for Lymphoid Cancer

1991 • 509 citations

A Controlled Trial of Amantadine and Rimantadine in the Prophylaxis of Influenza a Infection

1982 • 501 citations

Cytomegalovirus Pneumonia after Bone Marrow Transplantation Successfully Treated with the Combination of Ganciclovir and High-Dose Intravenous Immune Globulin

1988 • 499 citations

Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes

1988 • 486 citations

Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen

1987 • 485 citations

Mechanism of Action of 1-β-D-Ribofuranosyl-1,2,4-Triazole-3-Carboxamide (Virazole), A New Broad-Spectrum Antiviral Agent

1973 • 480 citations

Acyclovir-Resistant Herpes Simplex Virus Infections in Patients with the Acquired Immunodeficiency Syndrome

1989 • 470 citations

Herpes Simplex Encephalitis

1986 • 464 citations

The Site of Attachment in Human Rhinovirus 14 for Antiviral Agents That Inhibit Uncoating

1986 • 462 citations

Design, synthesis, and broad spectrum antiviral activity of 1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide and related nucleosides

1972 • 459 citations

Chronic Enteroviral Meningoencephalitis in Agammaglobulinemic Patients

1987 • 458 citations

Acyclovir for Prevention of Cytomegalovirus Infection and Disease after Allogeneic Marrow Transplantation

1988 • 456 citations

Effect of Continuous Intravenous Infusion of Zidovudine (AZT) in Children with Symptomatic HIV Infection

1988 • 452 citations

Randomized, controlled trial of recombinant human α-interferon in patients with chronic hepatitis B

1988 • 431 citations

Emergence and Apparent Transmission of Rimantadine-Resistant Influenza A Virus in Families

1989 • 421 citations

Progressive Disease Due to Ganciclovir-Resistant Cytomegalovirus in Immunocompromised Patients

1989 • 419 citations

Acyclovir Halts Progression of Herpes Zoster in Immunocompromised Patients

1983 • 416 citations

Long-Term Remission of Chronic Hepatitis B after Alpha-Interferon Therapy

1991 • 415 citations

Treatment of Serious Cytomegalovirus Infections with 9-(1,3-Dihydroxy-2-Propoxymethyl)Guanine in Patients with AIDS and Other Immunodeficiencies

1986 • 410 citations

Fusion mutants of the influenza virus hemagglutinin glycoprotein

1985 • 399 citations

Immunomodulatory and Antimicrobial Efficacy of Intravenous Immunoglobulin in Bone Marrow Transplantation

1990 • 398 citations

Psychiatric Complications of Long-term Interferon Alfa Therapy

1987 • 395 citations

Neuropsychological Outcome of Zidovudine (AZT) Treatment of Patients with AIDS and AIDS-Related Complex

1988 • 395 citations

2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 391 citations

A Controlled Trial Comparing Vidarabine with Acyclovir in Neonatal Herpes Simplex Virus Infection

1991 • 386 citations

Cytomegalovirus Retinitis and Acquired Immunodeficiency Syndrome

1989 • 385 citations

9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: a selective inhibitor of herpes group virus replication.

1983 • 384 citations

Decrease in Serum Hepatitis C Viral RNA during Alpha-Interferon Therapy for Chronic Hepatitis C

1991 • 383 citations

Activity of 9-[2-Hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine in the Treatment of Cytomegalovirus Pneumonia

1985 • 377 citations

Pharmacokinetics of acyclovir after intravenous and oral administration

1983 • 375 citations

Prevalence of Resistance in Patients Receiving Ganciclovir for Serious Cytomegalovirus Infection

1991 • 368 citations

Reversibility by dipyridamole of thallium-201 myocardial scan defects in patients with sarcoidosis

1988 • 366 citations

A Controlled Trial Comparing Foscarnet with Vidarabine for Acyclovir-Resistant Mucocutaneous Herpes Simplex in the Acquired Immunodeficiency Syndrome

1991 • 364 citations

Human Leukocyte Interferon for the Treatment of Herpes Zoster in Patients with Cancer

1978 • 359 citations

Herpes Simplex Virus Resistant to Acyclovir

1990 • 357 citations

Clinical Pharmacology of 3'-Azido-2',3'-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides

1989 • 356 citations

RESPONSE OF HUMAN-IMMUNODEFICIENCY-VIRUS-ASSOCIATED NEUROLOGICAL DISEASE TO 3'-AZIDO-3'-DEOXYTHYMIDINE

1987 • 352 citations

Acyclovir

1989 • 351 citations

Vidarabine Therapy of Neonatal Herpes Simplex Virus Infection

1980 • 350 citations

Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

1979 • 348 citations

Resistance to Antiviral Drugs of Herpes Simplex Virus Isolated from a Patient Treated with Acyclovir

1982 • 345 citations

A Double-Blind Study of Oral Acyclovir for Suppression of Recurrences of Genital Herpes Simplex Virus Infection

1984 • 340 citations

Antiviral effects of phosphonoformate (PFA, foscarnet sodium)

1982 • 339 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Aminosugar derivatives as potential anti-human immunodeficiency virus agents.

1988 • 336 citations

Synthesis and biological activities of iododeoxyuridine, an analog of thymidine

1959 • 332 citations

A Randomized Controlled Trial of a Reduced Daily Dose of Zidovudine in Patients with the Acquired Immunodeficiency Syndrome

1990 • 330 citations

Type B Hepatitis after Needle-Stick Exposure: Prevention with Hepatitis B Immune Globulin

1978 • 329 citations

A Randomized, Controlled Trial of Foscarnet in the Treatment of Cytomegalovirus Retinitis in Patients with AIDS

1991 • 329 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxycytidine, an inhibitor of HTLV-III infectivity

1986 • 326 citations

Computer-Aided Molecular Design

1987 • 324 citations

Treatment of First Episodes of Genital Herpes Simplex Virus Infection with Oral Acyclovir

1983 • 324 citations

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

1987 • 317 citations

Treatment of Varicella–Zoster Virus Infection in Severely Immunocompromised Patients

1986 • 313 citations

A Trial of Topical Acyclovir in Genital Herpes Simplex Virus Infections

1982 • 307 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Intravenous Immune Globulin for Prevention of Cytomegalovirus Infection and Interstitial Pneumonia After Bone Marrow Transplantation

1987 • 302 citations

Interferon Therapy for Condylomata Acuminata

1986 • 298 citations

Treatment of Recurrent Genital Herpes Simplex Infections With Oral Acyclovir

1984 • 297 citations

A Controlled Trial of Aerosolized Ribavirin in Infants Receiving Mechanical Ventilation for Severe Respiratory Syncytial Virus Infection

1991 • 295 citations

Adenine Arabinoside Therapy of Herpes Zoster in the Immunosuppressed

1976 • 293 citations

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

1989 • 293 citations

Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivative

1989 • 288 citations

Prospects for Treatment of Viral Hemorrhagic Fevers with Ribavirin, a Broad-Spectrum Antiviral Drug

1989 • 287 citations

Genetic basis of resistance to rimantadine emerging during treatment of influenza virus infection

1988 • 287 citations

Biologically diverse molecular variants within a single HIV-1 isolate

1988 • 285 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Prevention of Cytomegalovirus Infection by Cytomegalovirus Immune Globulin After Marrow Transplantation

1983 • 284 citations

Molecular Mechanisms of Action of Ribavirin

1990 • 284 citations

Ribavirin Antagonizes the Effect of Azidothymidine on HIV Replication

1987 • 282 citations

Plaque inhibition assay for drug susceptibility testing of influenza viruses

1980 • 280 citations

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

1987 • 279 citations

Human herpesviruses: a consideration of the latent state

1989 • 279 citations

Development of Non-Hodgkin Lymphoma in a Cohort of Patients with Severe Human Immunodeficiency Virus (HIV) Infection on Long-Term Antiretroviral Therapy

1990 • 275 citations

Herpes simplex virus latent phase transcription facilitates in vivo reactivation

1990 • 274 citations

Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection

1991 • 273 citations

Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections

1979 • 272 citations

Acyclovir-Resistant Varicella Zoster Virus Infection after Chronic Oral Acyclovir Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS)

1990 • 271 citations

Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase.

1980 • 269 citations

Therapy of herpes zoster with oral acyclovir.

1988 • 268 citations

Regulation of viral expression of human immunodeficiency virus in vitro by an antisense phosphorothioate oligodeoxynucleotide against rev (art/trs) in chronically infected cells.

1989 • 264 citations

Multicenter collaborative trial of intravenous acyclovir for treatment of mucocutaneous herpes simplex virus infection in the immunocompromised host

1982 • 263 citations

EFFICACY OF ORAL ACYCLOVIR IN THE TREATMENT OF INITIAL AND RECURRENT GENITAL HERPES

1982 • 263 citations

Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine

1983 • 262 citations

Oral Acyclovir for Prevention of Herpes Simplex Virus Reactivation After Marrow Transplantation

1984 • 261 citations

INHIBITION OF RESPIRATORY VIRUS INFECTION BY LOCALLY APPLIED INTERFERON

1973 • 261 citations

ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA

1988 • 261 citations

Ribavirin Aerosol Treatment of Bronchiolitis Associated with Respiratory Syncytial Virus Infection in Infants

1983 • 256 citations

Once-Daily Administration of 2′,3′-Dideoxyinosine (ddI) in Patients with the Acquired Immunodeficiency Syndrome or AIDS-Related Complex

1990 • 253 citations

Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein

1988 • 253 citations

Inhibition of Influenza Virus Ribonucleic Acid Polymerase by Ribavirin Triphosphate

1977 • 253 citations

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

1990 • 252 citations

Acyclovir therapy of chickenpox in immunosuppressed children—A collaborative study

1982 • 251 citations

Intravenous Immune Globulin for the Prevention of Bacterial Infections in Children with Symptomatic Human Immunodeficiency Virus Infection

1991 • 249 citations

Use of 5-Iodo-2'-Deoxyuridine (IDU) in Treatment of Herpes Simplex Keratitis

1962 • 249 citations

IS CYTOMEGALOVIRUS INTERSTITIAL PNEUMONITIS IN TRANSPLANT RECIPIENTS AN IMMUNOPATHOLOGICAL CONDITION?

1987 • 248 citations

A Phase I Evaluation of the Safety and Immunogenicity of Vaccination with Recombinant gp160 in Patients with Early Human Immunodeficiency Virus Infection

1991 • 248 citations

Clinical Pharmacokinetics of Interferons

1990 • 245 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

Oral Acyclovir in the Treatment of Acute Herpes Zoster Ophthalmicus

1986 • 244 citations

HEPATITIS B IMMUNE GLOBULIN (HBIG) EFFICACY IN THE INTERRUPTION OF PERINATAL TRANSMISSION OF HEPATITIS B VIRUS CARRIER STATE

1981 • 239 citations

ISOLATION AND CHARACTERISATION OF RESISTANT HERPES SIMPLEX VIRUS AFTER ACYCLOVIR THERAPY

1982 • 239 citations

ACYCLOVIR THERAPY FOR ACUTE HERPES ZOSTER

1982 • 239 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2',3'-dideoxynucleosides.

1988 • 235 citations

Metabolic activation of the nucleoside analog 9-[( 2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human diploid fibroblasts infected with human cytomegalovirus.

1985 • 233 citations

Human immunodeficiency virus reverse transcriptase. General properties and its interactions with nucleoside triphosphate analogs.

1987 • 232 citations

Therapeutic Efficacy of Amantadine HCl and Rimantadine HCl in Naturally Occurring Influenza A2 Respiratory Illness in Man

1969 • 230 citations

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

1980 • 229 citations

Specific structural alteration of the influenza haemagglutinin by amantadine.

1990 • 229 citations

PROPHYLACTIC TREATMENT OF SMALLPOX CONTACTS WITH N-METHYLISATIN β-THIOSEMICARBAZONE (COMPOUND 33T57, MARBORAN)

1963 • 227 citations

The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in Pathogenesis

1989 • 226 citations

A Multicenter Trial of Oral Zidovudine in Children with Advanced Human Immunodeficiency Virus Disease

1991 • 224 citations

Ribavirin Treatment of Respiratory Syncytial Viral Infection in Infants With Underlying Cardiopulmonary Disease

1985 • 223 citations

In vitro susceptibility of varicella-zoster virus to acyclovir

1980 • 222 citations

INHIBITION OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE III IN VITRO BY PHOSPHONOFORMATE

1985 • 221 citations

Interferon-α in Patients with Asymptomatic Human Immunodeficiency Virus (HIV) Infection

1990 • 221 citations

Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication

1980 • 219 citations

Foscarnet Therapy in Five Patients with AIDS and Acyclovir-resistant Varicella-Zoster Virus Infection

1991 • 218 citations

Cardiotoxicity of Interferon*

1991 • 218 citations

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1990 • 217 citations

Highly efficient neutralization of HIV with recombinant CD4-immunoglobulin molecules

1989 • 217 citations

Interferon-α with Zidovudine: Safety, Tolerance, and Clinical and Virologic Effects in Patients with Kaposi Sarcoma Associated with the Acquired Immunodeficiency Syndrome (AIDS)

1990 • 216 citations

1-(2,3-Dideoxy-.beta.-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent

1989 • 216 citations

Successful Treatment with Foscarnet of an Acyclovir-Resistant Mucocutaneous Infection with Herpes Simplex Virus in a Patient with Acquired Immunodeficiency Syndrome

1989 • 216 citations

Foscarnet Nephrotoxicity: Mechanism, Incidence and Prevention

1989 • 216 citations

Trisodium Phosphonoformate, a New Antiviral Compound

1978 • 214 citations

Dideoxyinosine in Children with Symptomatic Human Immunodeficiency Virus Infection

1991 • 213 citations

Prophylaxis and Treatment of Influenza

1990 • 213 citations

Intravenous Acyclovir for the Treatment of Primary Genital Herpes

1983 • 213 citations

Acyclovir-induced renal failure

1988 • 212 citations

ACYCLOVIR IN HERPES ZOSTER

1981 • 212 citations

Early Treatment with Acyclovir for Varicella Pneumonia in Otherwise Healthy Adults: Retrospective Controlled Study and Review

1990 • 211 citations

Circulating p24 Antigen Levels and Responses to Dideoxycytidine in Human Immunodeficiency Virus (HIV) Infections

1989 • 211 citations

The broad spectrum antiviral agent ribavirin inhibits capping of mRNA

1979 • 209 citations

Zoster Immune Globulin

1974 • 208 citations

Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

1981 • 208 citations

Susceptibilities of zidovudine-susceptible and -resistant human immunodeficiency virus isolates to antiviral agents determined by using a quantitative plaque reduction assay

1990 • 208 citations

Mechanism of phosphonoacetate inhibition of herpesvirus-induced DNA polymerase

1976 • 207 citations

Cytomegalovirus Retinitis and Response to Therapy with Ganciclovir

1987 • 206 citations

Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]

1989 • 206 citations

The Antiviral Activity of 9-β-D-Arabinofuranosyladenine (ARA-A)

1968 • 205 citations

Early Vidarabine Therapy to Control the Complications of Herpes Zoster in Immunosuppressed Patients

1982 • 205 citations

Oral acyclovir in acute herpes zoster.

1986 • 205 citations

Herpes simplex virus type 1 DNA polymerase

1989 • 204 citations

Effect of stage of disease and drug dose on zidovudine susceptibilities of isolates of human immunodeficiency virus.

1990 • 204 citations

Effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine on human cytomegalovirus replication in vitro

1983 • 202 citations

A Pilot Study of Low-Dose Zidovudine in Human Immunodeficiency Virus Infection

1990 • 201 citations

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

1989 • 201 citations

Use of Intravitreal Ganciclovir (Dihydroxy Propoxymethyl Guanine) for Cytomegalovirus Retinitis in a Patient With AIDS

1987 • 200 citations

Prolonged Zidovudine Therapy in Patients With AIDS and Advanced AIDS-Related Complex

1989 • 200 citations

Prevention of Natural Colds by Contact Prophylaxis with Intranasal Alpha₂-Interferon

1986 • 199 citations

Children With Influenza A Infection: Treatment With Rimantadine

1987 • 198 citations

Ganciclovir Treatment of Life- or Sight-Threatening Cytomegalovirus Infection: Experience in 314 Immunocompromised Patients

1988 • 197 citations

Acyclovir triphosphate is a suicide inactivator of the herpes simplex virus DNA polymerase.

1984 • 196 citations

Clinical Uses of Intravenous Immunoglobulins

1990 • 194 citations

Treatment of Cytomegalovirus Retinitis with 9-[2-Hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine

1985 • 193 citations

Granulocyte-macrophage colony-stimulating factor enhances neutrophil function in acquired immunodeficiency syndrome patients.

1988 • 193 citations

Combined Zidovudine and Interferon-α Therapy in Patients with Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 192 citations

Acyclovir treatment of varicella in otherwise healthy children

1990 • 192 citations

Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates

1982 • 191 citations

Natural Interferon Alfa for Treatment of Condylomata Acuminata

1988 • 189 citations

Acyclovir Prophylaxis Against Herpes Simplex Virus Infection in Patients with Leukemia

1983 • 188 citations

RIBAVIRIN SMALL-PARTICLE AEROSOL TREATMENT OF INFLUENZA

1981 • 188 citations

Molecular basis of resistance of influenza A viruses to amantadine

1986 • 187 citations

CLINICAL AND VIROLOGICAL EFFECTS OF HIGH-DOSE RECOMBINANT INTERFERON-α IN DISSEMINATED AIDS-RELATED KAPOSI'S SARCOMA

1988 • 187 citations

Toxicity of 3'-azido-3'-deoxythymidine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine for normal human hematopoietic progenitor cells in vitro

1987 • 186 citations

Recombinant Soluble CD4 Therapy in Patients with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 186 citations

Frequency and Significance of Acyclovir-Resistant Herpes Simplex Virus Isolated from Marrow Transplant Patients Receiving Multiple Courses of Treatment with Acyclovir

1983 • 184 citations

Structural analysis of a series of antiviral agents complexed with human rhinovirus 14.

1988 • 183 citations

Progressive Esophagitis from Acyclovir-Resistant Herpes Simplex

1989 • 183 citations

Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug

1986 • 181 citations

Isolation of drug-resistant variants of HIV-1 from patients on long-term zidovudine therapy

1989 • 181 citations

Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function.

1981 • 179 citations

EFFECTS OF ZIDOVUDINE IN 365 CONSECUTIVE PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX

1988 • 179 citations

LONG-TERM FOLLOW-UP IN A RANDOMISED CONTROLLED TRIAL OF RECOMBINANT α2-INTERFERON IN CHINESE PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1988 • 178 citations

Inhibition of uncoating of fowl plague virus by l-adamantanamine hydrochloride

1969 • 177 citations

Biological properties of a CD4 immunoadhesin

1990 • 176 citations

Pathogenicity of Acyclovir-Resistant Herpes Simplex Virus Type 1 from an Immunodeficient Child

1982 • 175 citations

Resistance of Influenza A Virus to Amantadine and Rimantadine: Results of One Decade of Surveillance

1989 • 173 citations

Ganciclovir-resistant cytomegalovirus clinical isolates: mode of resistance to ganciclovir

1991 • 171 citations

Prednisone Withdrawal Followed by Recombinant Alpha Interferon in the Treatment of Chronic Type B Hepatitis

1988 • 171 citations

Effects of Interferon-Alpha on Cytomegalovirus Reactivation Syndromes in Renal-Transplant Recipients

1983 • 170 citations

Long-term Acyclovir Suppression of Frequently Recurring Genital Herpes Simplex Virus Infection

1988 • 170 citations

Effect of Acyclovir on Infectious Mononucleosis: A Double-Blind, Placebo-Controlled Study

1986 • 169 citations

Successful treatment of naturally occurring influenza A/USSR/77 H1N1

1981 • 169 citations

Human Leukocyte Interferon for the Treatment of Varicella in Children with Cancer

1982 • 169 citations

INTRAVENOUS ACYCLOVIR TREATMENT FOR PRIMARY GENITAL HERPES

1982 • 168 citations

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

1987 • 167 citations

Treatment of Cytomegalovirus Retinitis with Trisodium Phosphonoformate Hexahydrate (Foscarnet)

1988 • 165 citations

Failure of Zidovudine Prophylaxis after Accidental Exposure to HIV-1

1990 • 165 citations

Survival Experience Among Patients With AIDS Receiving Zidovudine

1988 • 164 citations

Ganciclovir for the treatment and suppression of serious infections caused by cytomegalovirus

1987 • 163 citations

Foscarnet Therapy for Acyclovir-ResistantMucocutaneous Herpes Simplex Virus Infection in 26 AIDS Patients: Preliminary Data

1990 • 163 citations

RIBAVIRIN SUPPRESSES REPLICATION OF LYMPHADENOPATHY-ASSOCIATED VIRUS IN CULTURES OF HUMAN ADULT T LYMPHOCYTES

1984 • 163 citations

Prophylactic Efficacy of Intranasal Alpha₂-Interferon against Rhinovirus Infections in the Family Setting

1986 • 162 citations

Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus

1984 • 159 citations

Antiviral effects of phosphonoformate (pfa, foscarnet sodium)

1989 • 158 citations

Antibacterial activity and mechanism of action of 3'-azido-3'-deoxythymidine (BW A509U)

1987 • 158 citations

Prospects for the control of AIDS by immunizing seropositive individuals

1987 • 157 citations

Treatment of Recurrent Herpes Simplex Labialis with Oral Acyclovir

1990 • 157 citations

9-(1,3-dihydroxy-2-propoxymethyl) guanine (Ganciclovir) in the Treatment of Cytomegalovirus Gastrointestinal Disease with the Acquired Immunodeficiency Syndrome

1987 • 156 citations

Colony-Stimulating Factors and Host Defense

1989 • 155 citations

Foscarnet treatment of cytomegalovirus retinitis in patients with the acquired immunodeficiency syndrome

1989 • 155 citations

Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells.

1983 • 155 citations

A human cytomegalovirus mutant resistant to the nucleoside analog 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BW B759U) induces reduced levels of BW B759U triphosphate.

1986 • 154 citations

Continuous varicella-zoster infection associated with acyclovir resistance in a child with AIDS

1988 • 153 citations

Long-term Intravitreal Ganciclovir Therapy for Cytomegalovirus Retinopathy

1989 • 150 citations

Neurologic Symptoms Associated with Parenteral Acyclovir Treatment After Marrow Transplantation

1983 • 149 citations

A colorimetric assay for the measurement of the sensitivity of herpes simplex viruses to antiviral agents

1983 • 147 citations

Inhibition by acyclovir of cell growth and DNA synthesis of cells biochemically transformed with Herpesvirus genetic information

1980 • 147 citations

Enzymatic phosphorylation of acyclic nucleoside analogs and correlations with antiherpetic activities

1981 • 146 citations

HIV susceptibility conferred to human fibroblasts by cytomegalovirus-induced Fc receptor

1990 • 145 citations

Regression of oral hairy leukoplakia after orally administered acyclovir therapy

1988 • 142 citations

Initial studies on the cellular pharmacology of 2′,3′-dideoxyinosine, an inhibitor of HIV infectivity

1987 • 142 citations

Stimulation of Cellular Thymidine Kinases by Human Cytomegalovirus

1977 • 141 citations

HIV-Infected Cells Are Killed by rCD4-Ricin A Chain

1988 • 141 citations

Human Immunodeficiency Virus (HIV) Antigenemia (p24) in the Acquired Immunodeficiency Syndrome (AIDS) and the Effect of Treatment with Zidovudine (AZT)

1988 • 140 citations

Cost Effectiveness of Low-Dose Zidovudine Therapy for Asymptomatic Patients with Human Immunodeficiency Virus (HIV) Infection

1991 • 140 citations

Mode of action of 9-(4-hydroxy-3-hydroxymethylbut-1-yl)guanine (BRL 39123) against herpes simplex virus in MRC-5 cells

1989 • 139 citations

Acyclovir inhibition of Epstein-Barr virus replication.

1980 • 139 citations

Recovery of Human Immunodeficiency Virus Type 1 from Semen: Minimal Impact of Stage of Infection and Current Antiviral Chemotherapy

1991 • 139 citations

The metabolism of ribavirin in erythrocytes and nucleated cells

1990 • 138 citations

Embryotoxic, teratogenic, and metabolic effects of ribavirin in mice

1980 • 137 citations

Inhibition of immune functions by antiviral drugs.

1991 • 137 citations

Failure of High Dose 5-Iodo-2′-Deoxyuridine in the Therapy of Herpes Simplex Virus Encephalitis

1975 • 135 citations

Interferon in viral hepatitis: Role in pathogenesis and treatment

1986 • 134 citations

Neonatal Herpes Simplex Virus Infection: Follow-up Evaluation of Vidarabine Therapy

1983 • 134 citations

Pharmacokinetics of 2′, 3′-dideoxyadenosine and 2′, 3′-dideoxyinosine in patients with severe human immunodeficiency virus infection

1990 • 133 citations

Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine

1991 • 133 citations

The Safety and Pharmacokinetics of Recombinant Soluble CD4 (rCD4) in Subjects with the Acquired Immunodeficiency Syndrome (AIDS) and AIDS-Related Complex

1990 • 133 citations

Infections Caused by Herpes Simplex Virus in the Immunocompromised Host: Natural History And Topical Acyclovir Therapy

1984 • 132 citations

Pharmacokinetics, safety and preliminary clinical experiences using foscarnet in the treatment of cytomegalovirus infections in bone marrow and renal transplant recipients

1986 • 131 citations

Infectious Hepatitis

1960 • 130 citations

Oral Acyclovir Therapy for Mucocutaneous Herpes Simplex Virus Infections in Immunocompromised Marrow Transplant Recipients

1985 • 129 citations

Mode of action of ribavirin: Effect of nucleotide pool alterations on influenza virus ribonucleoprotein synthesis

1985 • 129 citations

Ganciclovir for the Treatment of Cytomegalovirus Gastroenteritis in Bone Marrow Transplant Patients

1990 • 127 citations

Toxicity of Combined Ganciclovir and Zidovudine for Cytomegalovirus Disease Associated with AIDS

1990 • 127 citations

Effects of 2′,3′‐dideoxynucleosides on mammalian cells and viruses

1984 • 127 citations

Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegaloviruses

1985 • 127 citations

Vidrabine therapy of varicella in immunosuppressed patients

1982 • 127 citations

PROPHYLACTIC ORAL ACYCLOVIR IN RECURRENT GENITAL HERPES

1984 • 126 citations

Prevention and Control of Influenza

1984 • 124 citations

Foscarnet-Induced Hypocalcemia and Effects of Foscarnet on Calcium Metabolism*

1991 • 123 citations

Metabolic pathways for the activation of the antiretroviral agent 2',3'-dideoxyadenosine in human lymphoid cells.

1988 • 123 citations

Antiviral activities of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4- carboxamide and related compounds

1991 • 123 citations

Prevention of Russian Influenza by Amantadine

1979 • 122 citations

Foscarnet in the Treatment of Cytomegalovirus Retinitis in Acquired Immune Deficiency Syndrome

1989 • 122 citations

Biologic Potential of Amantadine-Resistant Influenza A Virus in an Avian Model

1989 • 122 citations

Inhibition of cellular DNA polymerase alpha and human cytomegalovirus-induced DNA polymerase by the triphosphates of 9-(2-hydroxyethoxymethyl)guanine and 9-(1,3-dihydroxy-2-propoxymethyl)guanine

1985 • 121 citations

Treatment of primary first-episode genital herpes simplex virus infections with acyclovir: results of topical, intravenous and oral therapy

1983 • 118 citations

Structure-activity relationships of pyrimidine nucleosides as antiviral agents for human immunodeficiency virus type 1 in peripheral blood mononuclear cells

1989 • 117 citations

Acyclovir Prevents Reactivation of Herpes Simplex Labialis in Skiers

1988 • 117 citations

Treatment of Condyloma Acuminatum with Three Different Interferons Administered lntralesionally

1988 • 117 citations

Ribavirin Aerosol Treatment of Influenza B Virus Infection

1983 • 116 citations

Acquisition of Genital Herpes from an Asymptomatic Sexual Partner

1986 • 115 citations

Pharmacokinetic Disposition of Zidovudine during Pregnancy

1991 • 115 citations

Adverse Effects of High-Dose Intravenous Acyclovir in Ambulatory Patients with Acute Herpes Zoster

1985 • 114 citations

TREATMENT OF INVASIVE CYTOMEGALOVIRUS DISEASE IN SOLID ORGAN TRANSPLANT PATIENTS WITH GANCICLOVIR

1991 • 114 citations

PASSIVE IMMUNONEUTRALISATION OF HUMAN IMMUNODEFICIENCY VIRUS IN PATIENTS WITH ADVANCED AIDS

1988 • 112 citations

Lack of Effect of Peroral Acyclovir for the Treatment of Acute Infectious Mononucleosis

1991 • 112 citations

Aerosolized ribavirin in the treatment of patients with respiratory syncytial virus disease

1987 • 112 citations

Inhibition of Human Immunodeficiency Virus Type I (HIV-I) Replication by the Dipyridodiazepinone BI-RG-587

1991 • 112 citations

Cytomegalovirus (CMV)-Specific Intravenous Immunoglobulin for the Prevention of Primary CMV Infection and Disease after Marrow Transplant

1991 • 111 citations

Prolonged zidovudine therapy in patients with AIDS and advanced AIDS-related complex. AZT Collaborative Working Group

1989 • 110 citations

PROTECTIVE EFFECT OF 1-ADAMANTANAMINE HYDROCHLORIDE ON INFLUENZA A2 INFECTIONS IN THE FAMILY ENVIRONMENT

1969 • 109 citations

Effects of the nucleoside analog 2'-nor-2'-deoxyguanosine on human cytomegalovirus replication

1984 • 108 citations

Foscarnet Therapy for Severe Acyclovir-Resistant Herpes Simplex Virus Type-2 Infections in Patients with the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 107 citations

Herpes Simplex Virus Type 2 Meningoencephalitis Resistant to Acyclovir in a Patient with AIDS

1990 • 107 citations

Treatment of Cytomegalovirus Retinopathy in Patients With Acquired Immunodeficiency Syndrome

1986 • 107 citations

Clinical Pharmacokinetics of Ganciclovir in Patients with Normal and Impaired Renal Function

1988 • 107 citations

Intravenous Foscarnet for the Treatment of Severe Cytomegalovirus Infection in Allograft Recipients

1985 • 106 citations

Mode of Action of the Antiviral Activity of Amantadine in Tissue Culture

1965 • 106 citations

Susceptibility of influenza A viruses to amantadine is influenced by the gene coding for M protein

1978 • 105 citations

Reduction in fever and symptoms in young adults with influenza A/Brazil/78 H1N1 infection after treatment with aspirin or amantadine

1983 • 103 citations

Prolonged Continuous Acyclovir Treatment of Normal Adults With Frequently Recurring Genital Herpes Simplex Virus Infection

1991 • 102 citations

Characterization of a DNA Polymerase Mutant of Herpes Simplex Virus from a Severely Immunocompromised Patient Receiving Acyclovir

1989 • 102 citations

Low incidence of serum neutralizing factors in patients receiving recombinant alfa-2b interferon (intron a)

1986 • 102 citations

The prophylactic role of intravenous and long-term oral acyclovir after allogeneic bone marrow transplantation

1989 • 102 citations

Acyclovir Prevents Dissemination of Varicella in Immunocompromised Children

1988 • 102 citations

PROBENECID AND ZIDOVUDINE METABOLISM

1989 • 101 citations

Human herpesviruses: a consideration of the latent state.

1989 • 101 citations

Effect of ribavirin triphosphate on primer generation and elongation during influenza virus transcription in vitro

1985 • 101 citations

Decreased In Vitro Susceptibility to Zidovudine of HIV Isolates Obtained from Patients with AIDS

1990 • 100 citations

Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.

1982 • 100 citations

The Natural History of Ultraviolet Radiation-Induced Herpes Simplex Labialis and Response to Therapy with Peroral and Topical Formulations of Acyclovir

1991 • 99 citations

Initial studies on the cellular pharmacology of 2',3'-dideoxyadenosine, an inhibitor of HTLV-III infectivity

1987 • 99 citations

A microtiter virus yield reduction assay for the evaluation of antiviral compounds against human cytomegalovirus and herpes simplex virus

1990 • 99 citations

Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine

1991 • 96 citations

Non-Hodgkin's Lymphoma in Patients With Advanced HIV Infection Treated With Zidovudine

1991 • 96 citations

The role of interferons in the control of HIV replication in macrophages

1990 • 93 citations

Human pharmacokinetics and tolerance of oral ganciclovir

1987 • 92 citations

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

1981 • 92 citations

Effects of ribavirin on respiratory syncytial virus in vitro

1980 • 91 citations

Interferons And Their Actions

1987 • 91 citations

Toxicity of Adenine Arabinoside in Humans

1976 • 91 citations

Inhibition of cellular alpha and virally induced deoxyribonucleic acid polymerases by the triphosphate of acyclovir

1980 • 90 citations

Acyclovir in immunocompromised patients with cytomegalovirus disease

1982 • 89 citations

Dideoxycytidine alone and in an alternating schedule with zidovudine in children with symptomatic human immunodeficiency virus infection

1990 • 89 citations

Studies on the mechanism of the antiviral activity of ribavirin against reovirus

1989 • 89 citations

Long-term administration of 3?-Azido-2?,3?-dideoxythymidine to patients with AIDS-related neurological disease

1988 • 88 citations

Prevention of Herpesvirus Infections in Renal Allograft Recipients by Low-Dose Oral Acyclovir

1985 • 88 citations

Prophylactic Use of Human Leukocyte Interferon After Allogeneic Marrow Transplantation

1987 • 87 citations

GANCICLOVIR THERAPY OF SEVERE CYTOMEGALOVIRUS INFECTIONS IN SOLID-ORGAN TRANSPLANT RECIPIENTS

1988 • 87 citations

Synthetic peptides as substrates and inhibitors of a retroviral protease.

1988 • 87 citations

Ditiocarb Sodium (Diethyldithiocarbamate) Therapy in Patients With Symptomatic HIV Infection and AIDS

1991 • 86 citations

Topically Administered Acyclovir in the Treatment of Recurrent Herpes Simplex Genitalis: A Controlled Trial

1983 • 86 citations

Recurrent Genital Herpes and Suppressive Oral Acyclovir Therapy

1986 • 85 citations

Efficacy and safety of low dosage amantadine hydrochloride as prophylaxis for influenza A

1989 • 85 citations

Preclinical toxicology profile of acyclovir: An overview

1982 • 84 citations

Molecular Interactions among Herpesviruses and Human Immunodeficiency Viruses

1990 • 84 citations

METABOLIC EFFECTS OF 9-D-ARABINOSYLPURINES IN ASCITES TUMOR CELLS.

1964 • 84 citations

PPi analogs as inhibitors of human T-lymphotropic virus type III reverse transcriptase

1986 • 84 citations

Concurrent Zidovudine Levels in Semen and Serum Determined by Radioimmunoassay in Patients With AIDS or AIDS-Related Complex

1988 • 83 citations

Clinical isolate of herpes simplex virus type 2 that induces a thymidine kinase with altered substrate specificity

1987 • 82 citations

Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene

1986 • 82 citations

Anti-human immunodeficiency virus synergism by zidovudine (3'-azidothymidine) and didanosine (dideoxyinosine) contrasts with their additive inhibition of normal human marrow progenitor cells

1991 • 82 citations

The selectivity of action of an antiherpetic agent, 9‐(2‐hydroxyethoxymethyl) guanine

1999 • 81 citations

Ribavirin small-particle aerosol treatment of infections caused by influenza virus strains A/Victoria/7/83 (H1N1) and B/Texas/1/84

1985 • 81 citations

Oral rimantadine hydrochloride therapy of influenza A virus H3N2 subtype infection in adults

1986 • 80 citations

Effect of Foscarnet therapy on infection with human immunodeficiency virus in patients with AIDS.

1988 • 80 citations

A New Class of Synthetic Nucleoside Analogues with Broad-spectrum Antiviral Properties

1973 • 79 citations

Virulence of Rimantadine-Resistant Human Influenza A (H3N2) Viruses in Ferrets

1991 • 79 citations

Treatment of Cytomegaloviral Pneumonia with High-Dose Acyclovir and Human Leukocyte Interferon

1983 • 78 citations

Prevention of herpes zoster in patients by long-term oral acyclovir after allogeneic bone marrow transplantation.

1988 • 77 citations

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

1990 • 77 citations

A phase I study of recombinant human interferon-alpha 2a or human lymphoblastoid interferon-alpha n1 and concomitant zidovudine in patients with AIDS-related Kaposi's sarcoma.

1991 • 77 citations

A Trial of Vidarabine for Cytomegalovirus Infection in Renal Transplant Patients

1980 • 77 citations

Granulocyte-macrophage colony-stimulating factor mitigates the neutropenia of combined interferon alfa and zidovudine treatment of acquired immune deficiency syndrome-associated Kaposi's sarcoma.

1991 • 75 citations

Altered Sensitivity to Antiviral Drugs of Herpes Simplex Virus Isolates from a Patient with the Acquired Immunodeficiency Syndrome

1990 • 75 citations

Amantadine Effect on Peripheral Airways Abnormalities in Influenza

1976 • 75 citations

Psychiatric complications of long-term interferon alfa therapy

1987 • 74 citations

Kinetics of Inhibition of Deoxynucleotide‐Polymerizing Enzyme Activities from Normal and Leukemic Human Cells by 9‐β‐D‐Arabinofuranosyladenine 5′‐Triphosphate and 1‐β‐D‐Arabinofuranosylcytosine 5′‐Triphosphate

1977 • 73 citations

Enhanced efficacy of liposome-encapsulated ribavirin against Rift Valley fever virus infection in mice

1985 • 73 citations

Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization.

1991 • 73 citations

Ganciclovir Treatment of Gastrointestinal Infections Caused by Cytomegalovirus in Patients with AIDS

1988 • 73 citations

Syngeneic Bone Marrow Transplantation and Adoptive Transfer of Peripheral Blood Lymphocytes Combined with Zidovudine in Human Immunodeficiency Virus (HIV) Infection

1990 • 72 citations

Safety and Effects of Interleukin-2 Plus Zidovudine in Asymptomatic Individuals Infected with Human Immunodeficiency Virus

1991 • 71 citations

Treatment of influenza A (H1N1) virus infection with ribavirin aerosol

1984 • 71 citations

Human Monocytes Activated by Immunomodulators in Liposomes Lyse Herpesvirus-Infected But Not Normal Cells

1984 • 71 citations

Effectiveness of Rimantadine Prophylaxis of Children Within Families

1986 • 71 citations

The Efficacy of Inosine Pranobex in Preventing the Acquired Immunodeficiency Syndrome in Patients with Human Immunodeficiency Virus Infection

1990 • 70 citations

Spectrum of antiviral activity and mechanism of action of zidovudine. An overview.

1988 • 70 citations

A REVIEW OF SOME ASPECTS OF 5-IODODEOXYURIDINE AND AZAURIDINE.

1963 • 70 citations

A Collaborative Study of Patient-Initiated Treatment of Recurrent Genital Herpes with Topical Acyclovir or Placebo

1984 • 69 citations

Antiviral agents targeted to interact with viral capsid proteins and a possible application to human immunodeficiency virus.

1988 • 68 citations

Pharmacokinetics and absorption of foscarnet after intravenous and oral administration to patients with human immunodeficiency virus

1988 • 68 citations

Regulation of interferon receptor expression in human blood lymphocytes in vitro and during interferon therapy.

1986 • 68 citations

Zidovudine for Thrombocytopenic Purpura Related to Human Immunodeficiency Virus (HIV) Infection

1989 • 67 citations

Zidovudine-Associated Embryonic Toxicity in Mice

1991 • 66 citations

Improved DNA hybridization method for detection of acyclovir-resistant herpes simplex virus

1987 • 66 citations

Mechanism of La Crosse virus inhibition by ribavirin

1989 • 66 citations

Intranasal recombinant alfa-2b interferon treatment of naturally occurring common colds

1988 • 65 citations

Reversible Inhibition of Cytomegalovirus Replication by Phosphonoformate

1980 • 64 citations

Pharmacokinetics of foscarnet and distribution to cerebrospinal fluid after intravenous infusion in patients with human immunodeficiency virus infection

1989 • 64 citations

Pharmacokinetics of intermittently administered intravenous foscarnet in the treatment of acquired immunodeficiency syndrome patients with serious cytomegalovirus retinitis

1989 • 63 citations

In re ribavirin: A case of premature adjudication?

1988 • 63 citations

Direct Cerebrospinal Fluid Delivery of an Antiretroviral Agent Using Multivesicular Liposomes

1990 • 63 citations

Management of patients with suspected viral hemorrhagic fever.

1988 • 61 citations

Oral Acyclovir in the Therapy of Acute Herpes Zoster Ophthalmicus

1985 • 61 citations

Effect of Oral Acyclovir Treatment on Symptomatic and Asymptomatic Virus Shedding in Recurrent Genital Herpes

1989 • 61 citations

Effect of Immunoglobulin on Hepatitis A in Day-care Centers

1983 • 61 citations

Ganciclovir for Treatment of Renal Transplant-Associated Primary Cytomegalovirus Pneumonia

1988 • 60 citations

A Randomized Trial of Combination Therapy with Intralesional Interferon 2b and Podophyllin Versus Podophyllin Alone for the Therapy of Anogenital Warts

1990 • 60 citations

Prolonged continuous acyclovir treatment of normal adults with frequently recurring genital herpes simplex virus infection. The Acyclovir Study Group.

1991 • 59 citations

Early Application of Topical 15% Idoxuridine in Dimethyl Sulfoxide Shortens the Course of Herpes Simplex Labialis: A Multicenter Placebo-Controlled Trial

1990 • 59 citations

Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities

1985 • 59 citations

Protective efficacy of low-dose amantadine in adults challenged with wild-type influenza A virus

1987 • 58 citations

A Phase I/II Trial of Zidovudine, Interferon- , and Granulocyte-Macrophage Colony-Stimulating Factor in the Treatment of Human Immunodeficiency Virus Type 1 Infection

1991 • 58 citations

Hepatitis Prophylaxis Abroad

1969 • 58 citations

Evaluation of Therapeutic Efficacy of Amantadine in Patients With Naturally Occurring A2 Influenza

1970 • 58 citations

Oligodeoxynucleotides as Anti-Sense Inhibitors of Gene Expression: Therapeutic Implications

1989 • 57 citations

Metabolism of 9-β-d-Arabinofuranosyladenine by Mouse Fibroblasts

1975 • 56 citations

Protection of Man from Natural Infection with Influenza A2 Hong Kong Virus by Amantadine: A Controlled Field Trial

1970 • 55 citations

Effect of phosphorylated ribavirin on vesicular stomatitis virus transcription

1988 • 55 citations

Liposomes Modulate Human Immunodeficiency Virus Infectivity

1990 • 55 citations

Targets for the Design of Antiviral Agents

1984 • 55 citations

Foscarnet Therapy of Cytomegalovirus Retinitis in AIDS

1990 • 54 citations

Therapeutic Efficacy of Liposome-Encapsulated Ribavirin and Muramyl Tripeptide in Experimental Infection with Influenza or Herpes Simplex Virus

1987 • 54 citations

Intraventricular gamma-globulin for the management of enterovirus encephalitis

1988 • 54 citations

Problems of antiviral therapy

1983 • 54 citations

Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus

1982 • 53 citations

Treatment of Cytomegalovirus Pneumonia

1988 • 53 citations

SEQUENTIAL INTRAVENOUS AND TWICE-DAILY ORAL ACYCLOVIR FOR EXTENDED PROPIIZLAXIS OF HEAPFA SIMPLEX VIRUS INFECTION IN MARROW TRANSPIANT PATIENTS

1987 • 53 citations

Viral resistance, clinical experience.

1985 • 52 citations

Treatment of recurrent genital herpes simplex infections with oral acyclovir

1985 • 51 citations

Antiviral, immunosuppressive and antitumour effects of Ribavirin

1976 • 51 citations

Metabolism of ribavirin in respiratory syncytial virus-infected and uninfected cells

1986 • 50 citations

Antiviral Activity of Arabinosyladenine and Arabinosylhypoxanthine in Herpes Simplex Virus-Infected KB Cells: Selective Inhibition of Viral Deoxyribonucleic Acid Synthesis in the Presence of an Adenosine Deaminase Inhibitor

1976 • 49 citations

Acyclovir therapy during pregnancy.

1989 • 48 citations

Mucocutaneous Dissemination of Acyclovir-Resistant Herpes Simplex Virus in a Patient with AIDS

1989 • 48 citations

Excessive Serum Concentrations of Acyclovir and Neurotoxicity

1988 • 48 citations

Topical acyclovir in the treatment of initial genital herpes.

1983 • 47 citations

Vidarabine Therapy for Mucocutaneous Herpes Simplex Virus Infections in the Immunocompromised Host

1984 • 46 citations

Chemotherapy of Human Immunodeficiency Virus Infections: Current Practice and Future Prospects

1990 • 46 citations

Nature, time course and dose dependence of zidovudine-related side effects

1989 • 46 citations

Trigeminal ganglion infection by thymidine kinase-negative mutants of herpes simplex virus after in vivo complementation

1987 • 45 citations

Internucleotide incorporation of arabinosyladenine into herpes simplex virus and mammalian cell DNA

1981 • 45 citations

Biochemical pharmacology of zidovudine in human T-lymphoblastoid cells (CEM)

1989 • 45 citations

In vivo efficacy of zidovudine (3'-azido-3'-deoxythymidine) in experimental gram-negative-bacterial infections

1989 • 44 citations

In vitro and in vivo responses of cytomegalovirus to acyclovir

1982 • 42 citations

In Vivo Additive Antiretroviral Effect of Combined Zidovudine and Foscarnet Therapy for Human Immunodeficiency Virus Infection (ACTG Protocol 053)

1991 • 42 citations

Recombinant interferon alpha-2a for treatment of herpes zoster in immunosuppressed patients with cancer

1988 • 40 citations

Targeting of drug loaded immunoliposomes to herpes simplex virus infected corneal cells: an effective means of inhibiting virus replication in vitro.

1986 • 40 citations

Combined Treatment of Symptomatic Human Immunodeficiency Virus Type 1 Infection with Native Interferon- and Zidovudine

1991 • 39 citations

Rapid herpes simplex virus susceptibility testing using an enzyme-linked immunosorbent assay performed in situ on fixed virus-infected monolayers

1987 • 39 citations

Selective inhibition of functional lymphocyte subpopulations by ribavirin

1982 • 38 citations

Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir

1984 • 38 citations

Anti-human immunodeficiency virus agent 3'-azido-3'-deoxythymidine inhibits replication of Epstein-Barr virus

1988 • 37 citations

Combined ganciclovir and recombinant human granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients.

1991 • 37 citations

Basic approaches to anti-retroviral treatment.

1991 • 36 citations

Ribavirin pharmacodynamics in high-risk patients for acquired immunodeficiency syndrome

1987 • 36 citations

Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus.

1984 • 36 citations

Suppression of Recurrent Genital Herpes Simplex Virus Infection with Recombinant 2 Interferon

1986 • 36 citations

Immunologic Effects of Interferon

1990 • 35 citations

Oral Ribavirin Therapy for Subacute Sclerosing Panencephalitis

1989 • 34 citations

Rabies prevention--United States, 1984.

1984 • 34 citations

Interferon Alpha 2b Injections Used as an Adjuvant Therapy to Carbon Dioxide Laser Vaporization of Recalcitrant Ano-Genital Condylomata Acuminata

1990 • 33 citations

Nucleic acid hybridization, a method to determine effects of antiviral compounds on herpes simplex virus type 1 DNA synthesis

1984 • 33 citations

Inhibition of lymphocyte proliferative responses by ribavirin

1980 • 32 citations

Progressive mucocutaneous herpes simplex infection due to acyclovir-resistant virus in an immunocompromised patient: Correlation of viral susceptibilities and plasma levels with response to therapy

1987 • 32 citations

Transplacental passage of acyclovir

1986 • 32 citations

Treatment of Cytomegalovirus Retinopathy in Patients With Acquired Immunodeficiency Syndrome

1987 • 32 citations

General aspects of virus drug resistance with special reference to herpes simplex virus

1986 • 30 citations

Leukocyte Interferon for Treating First Episodes of Genital Herpes in Women

1987 • 30 citations

Foscarnet Therapy of Cytomegalovirus Retinitis in AIDS

1990 • 29 citations

Persistent herpes simplex virus infection and mechanisms of virus drug resistance

1989 • 28 citations

Determination of ribonucleoside triphosphate pools in influenza A virus-infected MDCK cells

1983 • 27 citations

Reversible Inhibition of Cellular Metabolism by Ribavirin

1978 • 27 citations

Alternating and intermittent regimens of zidovudine (3′-azido-3′-deoxythymidine) and dideoxycytidine (2′,3′-dideoxycytidine) in the treatment of patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1990 • 27 citations

Fate of influenza a virion proteins after entry into subcellular fractions of LLC cells and the effect of amantadine

1986 • 27 citations

Selective inhibition of RNA polyadenylation by Ara-ATP in vitro: A possible mechanism for antiviral action of Ara-A

1978 • 26 citations

Salvage therapy for zidovudine-intolerant HIV-infected patients with alternating and intermittent regimens of zidovudine and dideoxycytidine

1990 • 26 citations

Anti-human immunodeficiency virus type 1 activities and pharmacokinetics of novel 6-substituted acyclouridine derivatives

1990 • 26 citations

Response to Treatment with the Leukocyte-derived Immunomodulator IMREG-1 in Immunocompromised Patients with AIDS-related Complex

1991 • 25 citations

Clinics in Laboratory Medicine

2021 • 25 citations

Selective inhibition of herpesvirus DAN synthesis by foscarnet

1981 • 25 citations

Increased efficacy of phosphonoformate and phosphonoacetate inhibition of herpes simplex virus type 2 replication by encapsulation in liposomes

1988 • 25 citations

Effects of antiretroviral dideoxynucleosides on polymorphonuclear leukocyte function

1990 • 24 citations

Acyclovir treatment in primary Epstein-Barr virus infection. A double-blind placebo-controlled study.

1985 • 24 citations

Non-Hodgkin's lymphoma in patients with advanced HIV infection treated with zidovudine

1991 • 24 citations

A Phase 1 Study of Ribavirin in Human Immunodeficiency Virus-Infected Patients

1990 • 24 citations

Inactivation of S-adenosylhomocysteine hydrolase during adenine arabinoside therapy.

1982 • 22 citations

Ribavirin small-particle-aerosol treatment of influenza B virus infection

1988 • 22 citations

Physical and biological consequences of incorporation of antiviral agents into virus DNA

1984 • 22 citations

A trial of vidarabine for cytomegalovirus infection in renal transplant patients

1980 • 22 citations

Cytotoxic Activity Against HIV-infected Monocytes by Recombinant Interleukin 2-Activated Natural Killer Cells

1990 • 22 citations

Screening with a shell vial assay for antiviral activity against cytomegalovirus

1989 • 20 citations

Rimantadine hydrochloride blocks the second step of influenza virus uncoating

1980 • 20 citations

Rapid Methods for the Diagnosis of Viral Infections

1987 • 20 citations

Immunologic effects of long-term thymopentin treatment in patients with HIV-induced lymphadenopathy syndrome.

1989 • 19 citations

Evaluation of therapeutic efficacy of amantadine in patients with naturally occurring A2 influenza

1970 • 19 citations

Assessing Exposures of Health-Care Personnel to Aerosols of Ribavirin—California

1988 • 18 citations

A multicenter clinical trial of oral ribavirin in HIV-infected people with lymphadenopathy

1990 • 17 citations

Effect of immunoglobulin on hepatitis A in day-care centers

1983 • 16 citations

Purine Nucleoside Analogs as Antiviral Agents

1984 • 16 citations

Effect of continuous intravenous infusion of zidovudine (AZT) in children with symptomatic HIV infection

1989 • 16 citations

Lipid conjugates of antiretroviral agents. II. Disodium palmityl phosphonoformate: Anti-HIV activity, physical properties, and interaction with plasma proteins

1990 • 15 citations

Acyclovir‐resistant varicella zoster virus infection after chronic oral acyclovir therapy in patients with the acquired immunodeficiency syndrome (AIDS)

1990 • 15 citations

Cellular metabolism of 3'-azido-2',3'-dideoxyuridine with formation of 5'-O-diphosphohexose derivatives by previously unrecognized metabolic pathways for 2'-deoxyuridine analogs.

1990 • 14 citations

Structure of a human common cold virus and functional relationship to other picornaviruses

2014 • 14 citations

The Multiplication of Viruses

1958 • 13 citations

Prevention of natural colds by contact prophylaxis with intranasal alpha2-interferon.

1986 • 13 citations

Prevention of herpesvirus infections in renal allograft recipients by low-dose oral acyclovir

1985 • 13 citations

Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus.

1987 • 12 citations

Prolonged inhibitory effect of 9-(1,3-dihydroxy-2-propoxymethyl)guanine against replication of Epstein-Barr virus.

1984 • 12 citations

Aminosugar derivatives as potential anti-human immunodeficiency virus agents

1989 • 12 citations

Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl) guanine and Its Triphosphate

1979 • 12 citations

Characterization of a varicella-zoster virus variant with altered thymidine kinase activity

1986 • 11 citations

DIDEOXYINOSINE IN CHILDREN WITH SYMPTOMATIC HUMAN IMMUNODEFICIENCY VIRUS INFECTION

1991 • 11 citations

A Trial of Topical Acyclovir in Genital Herpes Simplex Virus Infections

1982 • 10 citations

Topical Acyclovir for Recurrent Herpes Labialis in Primary Care: Critical appraisal.

1991 • 9 citations

Acyclovir therapy during pregnancy.

1989 • 9 citations

Future directions in the management of cytomegalovirus infections.

1991 • 9 citations

Combined therapy with recombinant granulocyte colony-stimulating factor and erythropoietin decreases hematologic toxicity from zidovudine

1991 • 9 citations

Interferon Therapy for Condylomata Acuminata

1987 • 8 citations

Acyclovir inhibition of Epstein-Barr virus replication.

1980 • 8 citations

Specific interaction of CD4-bearing liposomes with HIV-infected cells.

1990 • 8 citations

Treatment of First Episodes of Genital Herpes Simplex Virus Infection with Oral Acyclovir

1983 • 7 citations

TREATMENT OF VARICELLA-ZOSTER VIRUS INFECTION IN SEVERELY IMMUNOCOMPROMISED PATIENTS

1987 • 7 citations

A multicenter clinical trial of oral ribavirin in HIV-infected patients with lymphadenopathy. The Ribavirin-LAS Collaborative Group.

1990 • 7 citations

Human Immunodeficiency Virus Reverse Transcriptase

2009 • 7 citations

Inhibitory Effects of Antiherpesviral Thymidine Analogs Against Varicella-Zoster Virus

1982 • 7 citations

Structural studies of the acquired immunodeficiency syndrome virus reverse transcriptase.

1988 • 6 citations

ChemInform Abstract: 1‐(2,3‐Dideoxy‐β‐D‐glycero‐pent‐2‐enofuranosyl)thymine. A Highly Potent and Selective Anti‐HIV Agent.

1989 • 6 citations

Ribavirin: a role in HIV infection?

1990 • 5 citations

Rapid method for determining the susceptibility of herpes simplex virus to acyclovir

1984 • 5 citations

AEROSOLIZED RIBAVIRIN TREATMENT OF INFANTS WITH RESPIRATORY SYNCYTIAL VIRAL INFECTION

1983 • 5 citations

HERPES SIMPLEX ENCEPHALITIS

1981 • 5 citations

Resistance of HCMV to DHPG, HPMPC and HPMPA mapped to the viral DNA polymerase gene

1991 • 5 citations

A double-blind, placebo-controlled trial of thymostimulin in symptomatic HIV-infected patients

1990 • 5 citations

Augmentation of natural cytotoxicity by leucine enkephalin in cultured peripheral blood mononuclear cells from patients infected with human immunodeficiency virus

1989 • 5 citations

A controlled trial comparing vidarabine with acyclovir in neonatal herpes simplex virus infection

1992 • 3 citations

Immune Modulators as Antiviral Agents

1987 • 3 citations

Granulocyte-Macrophage Colony-Stimulating Factor Mitigates the Neutropenia of Combined Interferon Alfa and Zidovudine Treatment in Acquired Immune Deficiency Syndrome-Associated Kaposi's Sarcoma

1992 • 1 citations

Further studies on the HIV proteinase inhibitor RO 31-8959

1991 • 1 citations

Deleted Work

1955 • 0 citations