The role of interferons in the control of HIV replication in macrophages

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma.

1984 • 1,083 citations

Dual Infection of the Central Nervous System by AIDS Viruses with Distinct Cellular Tropisms

1987 • 831 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4

1989 • 732 citations

Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow up of the San Francisco General Hospital cohort

1988 • 549 citations

Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes

1988 • 486 citations

Preliminary Observations on the Effect of Recombinant Leukocyte a Interferon in Homosexual Men with Kaposi's Sarcoma

1983 • 360 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

HTLV-III/LAV-Neutralizing Antibodies to anE. coli-Produced Fragment of the Virus Envelope

1986 • 336 citations

RECOMBINANT HUMAN INTERFERON ALFA-A SUPPRESSES HTLV-III REPLICATION IN VITRO

1985 • 306 citations

Virus Isolation From and Identification of HTLV-III/LAV-Producing Cells in Brain Tissue From a Patient With AIDS

1986 • 302 citations

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

1989 • 293 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Interferons and bacterial lipopolysaccharide protect macrophages from productive infection by human immunodeficiency virus in vitro.

1989 • 283 citations

ANTI-RETROVIRAL EFFECTS OF INTERFERON-α IN AIDS-ASSOCIATED KAPOSI'S SARCOMA

1988 • 261 citations

Modulation of CD4 antigen on macrophages and microglia in rat brain.

1987 • 229 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Use of gelatin/plasma coated flasks for isolating human peripheral blood monocytes

1983 • 224 citations

SEPTICÆMIA DUE TO PORCINE STREPTOCOCCI

1975 • 212 citations

Patients at Risk for AIDS-Related Opportunistic Infections

1985 • 197 citations

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism

1989 • 196 citations

Combined Zidovudine and Interferon-α Therapy in Patients with Kaposi Sarcoma and the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 192 citations

Detection of HTLV-III RNA in Lungs of Patients With AIDS and Pulmonary Involvement

1986 • 187 citations

CLINICAL AND VIROLOGICAL EFFECTS OF HIGH-DOSE RECOMBINANT INTERFERON-α IN DISSEMINATED AIDS-RELATED KAPOSI'S SARCOMA

1988 • 187 citations

Human Alpha- and Beta-Interferon But Not Gamma- Suppress theIn VitroReplication of LAV, HTLV-III, and ARV-2

1986 • 147 citations

Effect of interferon on exogenous, endogenous, and chronic murine leukemia virus infection

1976 • 137 citations

Severe Acquired Immune Deficiency Syndrome in Male Homosexuals: Diminished Capacity to Make Interferon-a in Vitro Associated with Severe Opportunistic Infections

1983 • 136 citations

Elastase-type proteases on the surface of human blood monocytes: possible role in amyloid formation.

1980 • 135 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon.

1986 • 133 citations

In vitro anti-human immunodeficiency virus activities of tumor necrosis factor-alpha and interferon-gamma.

1988 • 132 citations

Restricted replication of lentiviruses. Visna viruses induce a unique interferon during interaction between lymphocytes and infected macrophages.

1985 • 127 citations

Commentary from Westminster

1983 • 126 citations

Activity of Interferons Alpha, Beta, and Gamma Against Human Immunodeficiency Virus Replication In Vitro

1987 • 125 citations

Opportunistic infections in acquired immune deficiency syndrome result from synergistic defects of both the natural and adaptive components of cellular immunity.

1986 • 120 citations

Interferon-gamma concentrations are increased in sera from individuals infected with human immunodeficiency virus type 1.

1989 • 119 citations

Neopterin concentrations in cerebrospinal fluid and serum of individuals infected with HIV-1

1989 • 110 citations

Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome.

1986 • 108 citations

Persistent expression of Ia antigen and viral genome in visna-maedi virus-induced inflammatory cells. Possible role of lentivirus-induced interferon.

1985 • 103 citations

Serum neopterin changes in HIV-infected subjects: indicator of significant pathology, CD4 T cell changes, and the development of AIDS.

1989 • 102 citations

Interferon Production in Patients Infected with HIV-1

1989 • 100 citations

Inhibition of human immunodeficiency virus (HIV) replication by HIV-trans-activated alpha 2-interferon.

1989 • 95 citations

Elevated neopterin and beta2-microglobulin levels in blood and cerebrospinal fluid occur early in HIV-1 infection

1989 • 88 citations

Tryptophan Degradation in Patients Infected by Human Immunodeficiency Virus

1988 • 83 citations

Interferon, Double‐Stranded RNA and RNA Degradation

1977 • 78 citations

Agonist and antagonist effects of interferon alpha and beta on activation of human macrophages. Two classes of interferon gamma receptors and blockade of the high-affinity sites by interferon alpha or beta.

1988 • 77 citations

Human Biologic Response Modification by Interferon in the Absence of Measurable Serum Concentrations: A Comparative Trial of Subcutaneous and Intravenous Interferon-beta serine

1989 • 74 citations

Pharmacokinetic study of partially pure gamma-interferon in cancer patients.

1984 • 74 citations

Regulation of interferon receptor expression in human blood lymphocytes in vitro and during interferon therapy.

1986 • 68 citations

Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon

1986 • 64 citations

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages.

1989 • 58 citations

Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restricts the replication of caprine arthritis-encephalitis virus

1989 • 56 citations

Endogenous interferon production by endotoxin-responsive macrophages provides an autostimulatory differentiation signal

1984 • 53 citations

Neopterin: a predictive marker of acquired immune deficiency syndrome in human immunodeficiency virus infection.

1989 • 50 citations

Inhibition of Growth of HIV by Human Natural Interferon In Vitro

1988 • 50 citations

Effects of Human Immunodeficiency Virus on the Cellular Immune Response to Epstein-Barr Virus in Homosexual Men: Characterization of the Cytotoxic Response and Lymphokine Production

1987 • 48 citations

Restriction of HIV-1 replication in promonocytic cells: A role for IFN-α

1989 • 44 citations

Spontaneous interferon production by pulmonary leukocytes is associated with lentivirus-induced lymphoid interstitial pneumonia.

1988 • 44 citations

T4+ Cell Production of Interferon Gamma and the Clinical Spectrum of Patients at Risk for and With Acquired Immunodeficiency Syndrome

1988 • 44 citations

Serum 2-Microglobulin Decreases in Patients with AIDS or ARC Treated with Azidothymidine

1989 • 44 citations

Alpha‐ and gamma‐interferon (IFNα, IFNγ) but not interleukin‐1 (IL‐1) modulate synthesis and secretion of β₂‐microglobulin by hepatocytes

1988 • 43 citations

HIV replication can be blocked by recombinant human interferon beta

1989 • 42 citations

Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome.

1988 • 40 citations

Acid-labile human interferon alpha production by peripheral blood mononuclear cells stimulated by HIV-infected cells

1988 • 40 citations

HIV replication can be blocked by recombinant human interferon beta

1989 • 40 citations

Elevated Levels of Interferon-Induced 2'-5' Oligoadenylate Synthetase in Generalized Persistent Lymphadenopathy and the Acquired Immunodeficiency Syndrome

1985 • 35 citations

Suppression of p24 antigen in sera from HIV-infected individuals with low-dose α-interferon and zidovudine

1989 • 34 citations

Direct and Cell-Mediated Effects of Interferon-α and -γ on Cells Chronically Infected with HTLV-III

1986 • 33 citations

Treatment with recombinant IFN-gamma decreases cell surface CD4 levels on peripheral blood monocytes and on myelomonocyte cell lines.

1989 • 32 citations

ROLE OF INTERFERON IN AIDS^a

1984 • 32 citations

Recombinant human interferon gamma suppresses HTLV‐III replication in vitro

1986 • 32 citations

The Relationship of Serum Alpha-Interferon and Ultrastructural Markers in HIV-Seropositive Individuals

1987 • 28 citations

Interferon-Induced 2'-5' Oligoadenylate Synthetase During Interferon- Therapy in Homosexual Men with Kaposi's Sarcoma: Marked Deficiency in Biochemical Response to Interferon in Patients with Acquired Immunodeficiency Syndrome

1985 • 28 citations

Alteration of Nuclear (2´-5´) Oligoriboadenylate Synthetase and Nuclease Activities Preceding Replication of Human Immunodeficiency Virus in H9 Cells

1988 • 28 citations

HIV-1-specific production of IFN-gamma and modulation by recombinant IL-2 during early HIV-1 infection.

1988 • 26 citations

Association of alpha interferon production with natural killer cell lysis of U937 cells infected with human immunodeficiency virus

1989 • 25 citations

Interferon production in male homosexuals with the acquired immune deficiency syndrome (AIDS) or generalized lymphadenopathy

1984 • 25 citations

HIV antigen, HIV antibody and serum interferon in a patient with encephalopathy

1987 • 23 citations

Interferon inactivator(s) in patients with AIDS and AIDS-unrelated Kaposi's sarcoma

1986 • 20 citations

Fifty cases of human immunodeficiency virus (HIV) infection: immunoultrastructural study of circulating lymphocytes.

1988 • 19 citations

Down regulation of RNA labeling as a selective marker for cytotoxic but not suppressor macrophages.

1984 • 18 citations

Inhibition of viral reverse transcriptase by 2′,5′-oligoadenylates

1987 • 17 citations

The effect of interferon on cells persistently infected with HIV

1989 • 15 citations

Recombinant Human Interferon-β Suppresses the Replication of HIV and Acts Synergistically with AZT

1989 • 13 citations

Short communication

1988 • 13 citations

Gamma interferon regulates long terminal repeat-controlled oncogene expression in transformed mouse fibroblasts at the level of mRNA transcription

1988 • 13 citations

Analysis of the interferon system in African patients with acquired immunodeficiency syndrome

1985 • 13 citations

Dipyridamole potentiates the inhibition by 3'-azido-3'-deoxythymidine and other dideoxynucleosides of human immunodeficiency virus replication in monocyte-macrophages

1989 • 7 citations

Deleted Work

1955 • 0 citations