Pathogenicity of herpes simplex virus mutants containing drug resistance mutations in the viral DNA polymerase gene

Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent Disease

1975 • 337 citations

The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice

1978 • 337 citations

Two distinct loci confer resistance to acycloguanosine in herpes simplex virus type 1.

1980 • 285 citations

Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 • 245 citations

Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci.

1980 • 229 citations

Herpes simplex virus variants restraint to high concentrations of acyclovir exist in clinical isolates

1982 • 191 citations

Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

1985 • 172 citations

Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

1980 • 152 citations

Cell-mediated Immunity in Herpes Simplex Virus-infected Mice: Induction, Characterization and Antiviral Effects of Delayed Type Hypersensitivity

1980 • 117 citations

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

1985 • 113 citations

Virus drug-resistance: mechanisms and consequences

1984 • 108 citations

Generation of genetic diversity in herpes simplex virus: An antimutator phenotype maps to the DNA polymerase locus

1984 • 104 citations

Fine mapping and molecular cloning of mutations in the herpes simplex virus DNA polymerase locus

1984 • 102 citations

Characterization of the DNA polymerases induced by a group of herpes simplex virus type I variants selected for growth in the presence of phosphonoformic acid.

1982 • 100 citations

Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities

1981 • 92 citations

The distribution of herpes simplex type 1 antigen in mouse central nervous system after different routes of inoculation

1983 • 79 citations

The Sensitivity of Acyclovir-Resistant Mutants of Herpes Simplex Virus to Other Antiviral Drugs

1981 • 77 citations

Development of clinical resistance to acyclovir in herpes simplex virus-infected mice receiving oral therapy

1982 • 76 citations

Inhibition of cellular alpha DNA polymerase and herpes simplex virus-induced DNA polymerases by the triphosphate of BW759U

1984 • 75 citations

Mutations in the herpes simplex virus DNA polymerase gene can confer resistance to 9-beta-D-arabinofuranosyladenine

1982 • 74 citations

Resistance of herpes simplex virus to acycloguanosine—genetic and physical analysis

1980 • 70 citations

Selection and characterisation of acyclovir-resistant herpes simplex virus type 1 mutants inducing altered DNA polymerase activities

1985 • 59 citations

Phosphonoacetic Acid-Resistant Herpes Simplex Virus Infection in Hairless Mice

1975 • 51 citations

Treatment of Herpesvirus Infections

1983 • 44 citations

Resistance of Herpes Simplex Virus to Adenine Arabinoside and E-5-(2-Bromovinyl)-2′-Deoxyuridine: A Physical Analysis

1982 • 42 citations

Cooperative effects between two acyclovir resistance loci in herpes simplex virus

1984 • 40 citations

Pathogenesis of Experimental Skin Infections Induced by Drug-Resistant Herpes Simplex Virus Mutants

1981 • 40 citations

Characterization of latent infections in mice inoculated with herpes simplex virus which is clinically resistant to acyclovir

1984 • 37 citations

Atypical Patterns of Neural Infection Produced in Mice by Drugresistant Strains of Herpes Simplex Virus

1982 • 33 citations

Isolation of herpes simplex virus clones and drug resistant mutants in microcultures

1975 • 31 citations

Biochemical and genetic analysis of acyclovir-resistant mutants of herpes simplex virus type 1

1982 • 30 citations

RESISTANCE AND LATENCY

1985 • 19 citations

THE DEVELOPMENT OF RETINITIS IN MICE WITH NONFATAL HERPES SIMPLEX ENCEPHALITIS

1982 • 16 citations

Herpes simplex virus mutants resistant to arabinosyladenine in the presence of deoxycoformycin

1984 • 9 citations

Deleted Work

1955 • 0 citations