Analysis of the functions of the first epidermal growth factor-like domain of factor X.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Surface-dependent reactions of the vitamin K-dependent enzyme complexes

1990 • 853 citations

The Conversion of Prothrombin to Thrombin

1974 • 366 citations

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

1979 • 356 citations

The first EGF-like domain from human factor IX contains a high-affinity calcium binding site.

1990 • 190 citations

How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

1992 • 166 citations

Structure-function relationships of epidermal growth factor modules in vitamin K-dependent clotting factors

1991 • 157 citations

How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X.

1992 • 157 citations

Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid.

1983 • 127 citations

The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives.

1992 • 114 citations

Deletion of the membrane anchoring region of tissue factor abolishes autoactivation of factor VII but not cofactor function. Analysis of a mutant with a selective deficiency in activity.

1992 • 111 citations

Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid.

1984 • 101 citations

Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid.

1990 • 97 citations

Calcium-binding properties of bovine factor X lacking the gamma-carboxyglutamic acid-containing region.

1984 • 96 citations

Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody

1992 • 89 citations

Localization of the human tissue factor recognition determinant of human factor VIIa.

1991 • 85 citations

Antibody-probed conformational transitions in the protease domain of human factor IX upon calcium binding and zymogen activation: putative high-affinity Ca(2+)-binding site in the protease domain.

1992 • 79 citations

Calcium-dependent interaction between the epidermal growth factor precursor-like region of human protein C and a monoclonal antibody.

1987 • 65 citations

Protein structural requirements for Ca2+ binding to the light chain of factor X. Studies using isolated intact fragments containing the gamma-carboxyglutamic acid region and/or the epidermal growth factor-like domains

1991 • 62 citations

Comparison of coagulation factor Xa and des-(1-44)factor Xa in the assembly of prothrombinase.

1984 • 62 citations

Characterization of the functional defect in factor IX Alabama. Evidence for a conformational change due to high affinity calcium binding in the first epidermal growth factor domain.

1990 • 59 citations

Calcium binding to a human factor IXa derivative lacking γ-carboxyglutamic acid: Evidence for two high-affinity sites that do not involve β-hydroxyaspartic acid

1985 • 46 citations

Effects of gamma-carboxyglutamic acid and epidermal growth factor-like modules of factor IX on factor X activation. Studies using proteolytic fragments of bovine factor IX.

1992 • 43 citations

Construction, expression, and characterization of a chimera of factor IX and factor X. The role of the second epidermal growth factor domain and serine protease domain in factor Va binding.

1992 • 40 citations

The role of calcium ions in factor X activation by thrombin E192Q.

1992 • 40 citations

Proteolytic formation and properties of a fragment of protein C containing the .gamma.-carboxyglutamic acid rich domain and the EGF-like region

1990 • 39 citations

The gamma-carboxyglutamic acid and epidermal growth factor-like domains of factor X. Effect of isolated domains on prothrombin activation and endothelial cell binding of factor X

1991 • 33 citations

The high affinity calcium-binding site involved in protein C activation is outside the first epidermal growth factor homology domain.

1992 • 29 citations

Inhibition of prothrombin activation by factor X and factor IX Gla-peptides

1988 • 4 citations