Role of proofreading and mismatch repair in maintaining the stability of nucleotide repeats in DNA

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions.

1989 • 451 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication in E. coli

1995 • 353 citations

The mutY gene: a mutator locus in Escherichia coli that generates G.C----T.A transversions.

1988 • 343 citations

PROKARYOTIC DNA REPLICATION

1992 • 319 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Interspecies gene exchange in bacteria: The role of SOS and mismatch repair systems in evolution of species

1995 • 298 citations

Instability of simple sequence DNA in Saccharomyces cerevisiae.

1992 • 240 citations

Localized Mutagenesis of Any Specific Small Region of the Bacterial Chromosome

1971 • 236 citations

Polymerase structures and function: variations on a theme?

1995 • 192 citations

The fidelity of DNA synthesis catalyzed by derivatives of Escherichia coli DNA polymerase I.

1990 • 169 citations

Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe.

1996 • 163 citations

The extreme mutator effect of Escherichia coli mutD5 results from saturation of mismatch repair by excessive DNA replication errors.

1989 • 149 citations

Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb Subdomain

1995 • 121 citations

Exonucleolytic Proofreading during Replication of Repetitive DNA

1996 • 111 citations

Spontaneous and UV-induced mutations in Escherichia coli K-12 strains with altered or absent DNA polymerase I

1989 • 73 citations

Sequence analysis of the Escherichia coli dnaE gene

1987 • 73 citations

Editing DNA replication and recombination by mismatch repair: from bacterial genetics to mechanisms of predisposition to cancer in humans

1995 • 73 citations

Identification of the dnaQ gene product and location of the structural gene for RNase H of Escherichia coli by cloning of the genes.

1981 • 54 citations

An Escherichia coli dnaE mutation with suppressor activity toward mutator mutD5

1992 • 48 citations

Structure and function ofdnaQ andmutD mutators ofEscherichia coli

1986 • 42 citations

Specificity and enzymatic mechanism of the editing exonuclease of Escherichia coli DNA polymerase III.

1991 • 34 citations

Description of a new amplifiable shuttle vector for mutagenesis studies in human cells: application to N-methyls-N′-nitro-N-nitrosoguanidine-induced mutation spectrum

1992 • 23 citations

Production of UV-induced Frameshift Mutations in Vitro by DNA Polymerases Deficient in 3′ → 5′ Exonuclease Activity

1994 • 11 citations