Hidden Markov Model Analysis of Motifs in Steroid Dehydrogenases and Their Homologs

Basic local alignment search tool

1990 • 87,358 citations

A tutorial on hidden Markov models and selected applications in speech recognition

1989 • 22,242 citations

PHYLIP-Phylogeny inference package (Version 3.2)

1989 • 17,674 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd

1995 • 5,571 citations

The Minimal Gene Complement of Mycoplasma genitalium

1995 • 2,499 citations

Introduction to Protein Structure

2012 • 2,404 citations

The relation between the divergence of sequence and structure in proteins.

1986 • 2,373 citations

Hidden Markov Models in Computational Biology

1994 • 1,954 citations

inhA , a Gene Encoding a Target for Isoniazid and Ethionamide in Mycobacterium tuberculosis

1994 • 1,348 citations

Profile analysis: detection of distantly related proteins.

1987 • 1,308 citations

Short-chain dehydrogenases/reductases (SDR)

1995 • 1,228 citations

Prediction of the occurrence of the ADP-binding βαβ-fold in proteins, using an amino acid sequence fingerprint

1986 • 1,172 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

The value of prior knowledge in discovering motifs with MEME.

1995 • 673 citations

Evolution of the nuclear receptor gene superfamily.

1992 • 662 citations

Interaction of pyrophosphate moieties with .alpha.-helixes in dinucleotide-binding proteins

1985 • 475 citations

Hidden Markov models of biological primary sequence information.

1994 • 465 citations

Automated assembly of protein blocks for database searching

1991 • 465 citations

Characteristics of short‐chain alcohol dehydrogenases and related enzymes

1991 • 452 citations

The human gene for 11 beta-hydroxysteroid dehydrogenase. Structure, tissue distribution, and chromosomal localization.

1991 • 434 citations

Multiple alignment using hidden Markov models.

1995 • 425 citations

The root of the universal tree and the origin of eukaryotes based on elongation factor phylogeny.

1996 • 274 citations

Crystal Structures of the Binary and Ternary Complexes of 7α-Hydroxysteroid Dehydrogenase from Escherichia coli^,

1996 • 233 citations

Introduction to protein structure

1992 • 213 citations

The structure of a complex of human 17β-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

1996 • 207 citations

The refined three-dimensional structure of 3α,20β-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases

1994 • 199 citations

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: Evidence for involvement of tyrosine-152 and lysine-156 in catalysis

1993 • 151 citations

A light-dependent complementation system for analysis of NADPH:protochlorophyllide oxidoreductase: identification and mutagenesis of two conserved residues that are essential for enzyme activity.

1995 • 124 citations

Tyr-179 and Lys-183 are essential for enzymatic activity of 11β-hydroxysteroid dehydrogenase

1992 • 116 citations

Sequencing and analysis of bacterial genomes

1996 • 112 citations

Expansion of the mammalian 3β‐hydroxysteroid dehydrogenase/plant dihydroflavonol reductase superfamily to include a bacterial cholesterol dehydrogenase, a bacterial UDP‐galactose‐4‐epimerase, and open reading frames in vaccinia virus and fish lymphocystis disease virus

1992 • 112 citations

Common themes in redox chemistry emerge from the X-ray structure of oilseed rape (Brassica napus) enoyl acyl carrier protein reductase

1995 • 109 citations

11β-Hydroxysteroid dehydrogenase and the short-chain alcohol dehydrogenase (SCAD) superfamily

1992 • 100 citations

ParaMEME: a parallel implementation and a web interface for a DNA and protein motif discovery tool

1996 • 83 citations

Site-directed mutagenesis of the putative active site of human 17β-hydroxysteroid dehydrogenase type 1

1994 • 79 citations

Structural comparisons lead to the definition of a new superfamily of NAD(P)(H)-accepting oxidoreductases: the single-domain reductases/epimerases/dehydrogenases (the ‘RED’ family)

1994 • 77 citations

Structural and mechanistic characteristics of dihydropteridine reductase: a member of the Tyr-(Xaa)3-Lys-containing family of reductases and dehydrogenases.

1994 • 58 citations

Cloning of Two Halohydrin Hydrogen–Halide–Lyase Genes ofCorynebacteriumsp. Strain N-1074 and Structural Comparison of the Genes and Gene Products

1994 • 53 citations

Protein engineering of Drosophila alcohol dehydrogenase The hydroxyl group of Tyr¹⁵² is involved in the active site of the enzyme

1992 • 52 citations

Unusual evolution of 11β‐ and 17β‐hydroxysteroid and retinol dehydrogenases

1996 • 50 citations

Sequence analysis of steroid- and prostaglandin-metabolizing enzymes: Application to understanding catalysis

1994 • 47 citations

Genealogy of regulation of human sex and adrenal function, prostaglandin action, snapdragon and petunia flower colors, antibiotics, and nitrogen fixation: functional diversity from two ancestral dehydrogenases

1991 • 46 citations

NADP-dependent 15-hydroxyprostaglandin dehydrogenase is homologous to NAD-dependent 15-hydroxyprostaglandin dehydrogenase and other short-chain alcohol dehydrogenases

1992 • 25 citations

Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase

1995 • 24 citations

Structures important in mammalian 11β- and 17β-hydroxysteroid dehydrogenases

1995 • 22 citations

Structures Stabilizing the Dimer Interface on Human 11β-Hydroxysteroid Dehydrogenase Types 1 and 2 and Human 15-Hydroxyprostaglandin Dehydrogenase and Their Homologs

1995 • 18 citations