Lack of intermediate‐affinity interleukin‐2 receptor in mice leads to dependence on interleukin‐2 receptor α, β and γ chain expression for T cell growth

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells.

1981 • 1,366 citations

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

1984 • 858 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

The IL-2/IL-2 receptor system: A current overview

1993 • 778 citations

Low and high affinity cellular receptors for interleukin 2. Implications for the level of Tac antigen.

1984 • 742 citations

Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4

1993 • 734 citations

Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's

1989 • 680 citations

The IL-2 Receptor Complex: Its Structure, Function, and Target Genes

1993 • 601 citations

Interleukin 2 high-affinity receptor expression requires two distinct binding proteins.

1987 • 565 citations

Identification and initial characterization of a rat monoclonal antibody reactive with the murine interleukin 2 receptor-ligand complex.

1983 • 348 citations

Interleukin 2 (IL-2) augments transcription of the IL-2 receptor gene.

1985 • 280 citations

Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies.

1989 • 219 citations

A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells.

1991 • 158 citations

Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells.

1994 • 129 citations

Interleukin 2 upregulates expression of its receptor on a T cell clone.

1985 • 102 citations

Monoclonal antibodies identify three epitope clusters on the mouse p55 subunit of the interleukin 2 receptor: relationship to the interleukin 2‐binding site

1987 • 93 citations

Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice

1988 • 70 citations

Control of IL-2 receptor-alpha expression by IL-1, tumor necrosis factor, and IL-2. Complex regulation via elements in the 5' flanking region.

1990 • 61 citations

Anti‐interleukin 2 receptor monoclonal antibodies. Respective role of epitope mapping and monoclonal antibody‐receptor interactions in their antagonist effects on interleukin 2‐dependent T cell growth

1986 • 59 citations

Internalization of interleukin 2 (IL-2) by high affinity IL-2 receptors is required for the growth of IL-2-dependent T cell lines.

1987 • 55 citations

Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human Receptors

1993 • 52 citations

Receptor antagonist and selective agonist derivatives of mouse interleukin-2.

1992 • 45 citations

Regulation of interleukin 2 (IL2) receptor expression: IL 2 as an inducing signal for the expression of its own receptor on a murine T helper cell line

1985 • 44 citations

Interleukin 2 receptor beta chain expressed in an oligodendroglioma line binds interleukin 2 and delivers growth signal.

1990 • 40 citations

Differences in the interleukin‐2 (IL‐2) receptor system in human and mouse: α chain is required for formation of the functional mouse IL‐2 receptor

1995 • 37 citations

High-affinity and intermediate-affinity forms of the human interleukin 2 receptor, expressed in an interleukin 9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways

1993 • 32 citations

Control of the IL-2 responsiveness of B lymphocytes by IL-2 and IL-4.

1995 • 28 citations

Activation by IL-2, but not IL-4, up-regulates the expression of the p55 subunit of the IL-2 receptor on IL-2- and IL-4-dependent T cell lines.

1989 • 23 citations

Dysregulated expression of the IL-2 receptor β-chain abrogates development of NK cells and Thy-1⁺ dendritic epidermal cells in transgenic mice

1995 • 22 citations

IL-2-dependent proliferation of murine T cells requires expression of both the p55 and p70 subunits of the IL-2 receptor.

1990 • 21 citations

Cytokine receptors: a combinative family of molecules.

1994 • 21 citations

In vitro induction and expression of interleukin 2 receptor in a clonal T helper cell differentiation model

1984 • 20 citations

Gene transfer of the interleukin (IL)‐2 receptor β chain into an IL‐7‐dependent pre‐B cell line permits IL‐2‐driven proliferation: Tyrosine phosphorylation of Shc is induced by IL‐2 but not IL‐7

1994 • 19 citations

IL-2 can support growth of CD8+ T cells but not CD4+ T cells of human IL-2 receptor beta-chain transgenic mice.

1994 • 17 citations

Induction of mouse p55 interleukin-2 receptor gene expression by IL-2 and IL-4 and characterization of its transcription initiation sites

1991 • 15 citations

Mutation of Asp²⁰ of human interleukin‐2 reveals a dual role of the p55 α chain of the interleukin‐2 receptor

1993 • 14 citations

Selection of internalization‐deficient cells by interleukin‐2‐Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin‐2 receptor β chain does not contribute to internalization of interleukin‐2

1993 • 11 citations