Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone

1990 • 1,605 citations

Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction

1990 • 1,583 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes.

1989 • 912 citations

Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene

1987 • 760 citations

New type of POU domain in germ line-specific protein Oct-4

1990 • 753 citations

Mammalian genes coordinately regulated by growth arrest signals and DNA-damaging agents.

1989 • 698 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

A potential animal model for Lesch–Nyhan syndrome through introduction of HPRT mutations into mice

1987 • 487 citations

On the enzymic defects in hereditary tyrosinemia.

1977 • 453 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

[30] DT-diaphorase: Purification, properties, and function

1990 • 316 citations

Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.

1992 • 308 citations

Mutual transrepression of Fos and the glucocorticoid receptor: involvement of a functional domain in Fos which is absent in FosB.

1990 • 290 citations

The occurrence of hepatoma in the chronic form of hereditary tyrosinemia

1976 • 282 citations

Is CCAAT/enhancer-binding protein a central regulator of energy metabolism?

1989 • 266 citations

Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor

1991 • 234 citations

Genetic control of morphogenetic and biochemical differentiation: Lethal albino deletions in the mouse

1979 • 221 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Glucocorticoids are required for establishment and maintenance of an alteration in chromatin structure: induction leads to a reversible disruption of nucleosomes over an enhancer.

1991 • 206 citations

Cellular responses to oxidative stress: the [Ah] gene battery as a paradigm.

1990 • 197 citations

Cell-specific inhibitory and stimulatory effects of Fos and Jun on transcription activation by nuclear receptors.

1991 • 195 citations

Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes.

1992 • 189 citations

Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing.

1988 • 184 citations

A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1

1990 • 154 citations

Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes

1990 • 149 citations

Cloning and expression of the cDNA encoding human fumarylacetoacetate hydrolase, the enzyme deficient in hereditary tyrosinemia: assignment of the gene to chromosome 15.

1991 • 117 citations

ANALYSIS OF THE ALBINO-LOCUS REGION OF THE MOUSE: IV. CHARACTERIZATION OF 34 DEFICIENCIES

1982 • 113 citations

Hereditary tyrosinemia type I--an overview.

1986 • 107 citations

Different molecular basis for fumarylacetoacetate hydrolase deficiency in the two clinical forms of hereditary tyrosinemia (type I).

1990 • 98 citations

Visceral pathology of hereditary tyrosinemia type I.

1990 • 95 citations

Rat mitochondrial and cytosolic 3-hydroxy-3-methylglutaryl-CoA synthases are encoded by two different genes.

1990 • 85 citations

HOMOGENTISATE METABOLISM: THE ISOMERIZATION OF MALEYLACETOACETATE BY AN ENZYME WHICH REQUIRES GLUTATHIONE

1956 • 83 citations

NAD(P)H:menadione oxidoreductase. Novel purification of enzyme cDNA and complete amino acid sequence, and gene regulation.

1986 • 82 citations

Biochemical Observations on So-called Hereditary Tyrosinemia

1970 • 80 citations

Hereditary tyrosinemia type I (chronic form): Pathologic findings in the liver

1989 • 79 citations

Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase

1989 • 75 citations

Hepatocyte differentiation in culture. Appearance of tyrosine aminotransferase

1979 • 73 citations

Assay, properties and tissue distribution of p-hydroxyphenylpyruvate hydroxylase

1972 • 66 citations

Murine fumarylacetoacetate hydrolase (Fah) gene is disrupted by a neonatally lethal albino deletion that defines the hepatocyte-specific developmental regulation 1 (hsdr-1) locus.

1992 • 66 citations

Glucose-6-phosphatase deficiency caused by radiation-induced alleles at the albino locus in the mouse.

1968 • 65 citations

Deletions near the albino locus on chromosome 7 of the mouse affect the level of tyrosine aminotransferase mRNA.

1985 • 62 citations

Ionic calcium levels during pregnancy, at delivery and in the first hours of life

1986 • 55 citations

ULTRASTRUCTURAL BASIS OF BIOCHEMICAL EFFECTS IN A SERIES OF LETHAL ALLELES IN THE MOUSE

1973 • 54 citations

Trans regulation of the phosphoenolpyruvate carboxykinase (GTP) gene, identified by deletions in chromosome 7 of the mouse.

1986 • 52 citations

Multiple biochemical effects of a series of X-ray induced mutations at the albino locus in the mouse

1973 • 44 citations

Biochemical Studies of a Patient with Hereditary Hepatorenal Tyrosinemia: Evidence of Glutathione Deficiency

1984 • 43 citations

Transcriptional control in hepatocytes of normal and c14CoS albino deletion mice.

1992 • 40 citations

Marked increases in hepatic NAD(P)H:oxidoreductase gene transcription and mRNA levels correlated with a mouse chromosome 7 deletion.

1989 • 38 citations

Regulatory genes in development

1987 • 35 citations

Metallothionein mRNA expression in mice homozygous for chromosomal deletions around the albino locus.

1988 • 32 citations

Nucleotide sequence of cDNA encoding human fumarylacetoacetase

1990 • 30 citations

Tyrosine aminotransferase induction in hepatocytes cultured from rat foetuses treated with dexamethasone in utero

1979 • 28 citations

Physical mapping of the albino-deletion complex in the mouse to localize alf/hsdr-1, a locus required for neonatal survival

1992 • 28 citations

Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes.

1984 • 28 citations

DecreasedHnf-1Gene Expression in Mice Homozygous for a 1.2-CentiMorgan Deletion on Chromosome 7

1990 • 27 citations

Hereditary Tyrosinemias (Type I): A New Vista on Tyrosine Toxicity and Cancer

1986 • 25 citations

Effects of deletions in mouse chromosome 7 on expression of genes encoding the urea-cycle enzymes and phosphoenolpyruvate carboxykinase (GTP) in liver, kidney, and intestine

1988 • 24 citations

Mice homozygous for chromosomal deletions at the albino locus region lack specific polypeptides in two-dimensional gels.

1984 • 21 citations

Genetically determined abnormalities of microsomal enzymes in liver of mutant newborn mice

1976 • 21 citations

Developmental regulation of constitutive and inducible expression of hepatocyte-specific genes in the mouse.

1988 • 19 citations

Premature development of ligandin (GSH transferase B) in mice with an inherited defect in endoplasmic reticulum-golgi structure and function

1977 • 19 citations

The source of aromatic ketoacids in tyrosinaemia and phenylketonuria

1972 • 18 citations

Chromosome jumping from flanking markers defines the minimal region for alf/hsdr-1 within the albino-deletion complex

1992 • 18 citations

The glucocorticoid hormone signal transduction pathway in mice homozygous for chromosomal deletions causing failure of cell type-specific inducible gene expression.

1991 • 16 citations

Biochemical evidence of carnitine effect on propionate elimination

1984 • 13 citations

Oral loading of homogentisic acid in controls and in obligate heterozygotes for hereditary tyrosinemia type I.

1990 • 7 citations

Linker scanning mutagenesis

1991 • 2 citations