Induction of Cytotoxic T Lymphocyte Antigen 4 (Ctla-4) <u>Restricts</u> Clonal Expansion of Helper T Cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

1995 • 2,842 citations

CTLA-4 can function as a negative regulator of T cell activation

1994 • 2,107 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

Determination of lymphocyte division by flow cytometry

1994 • 1,712 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

2000 • 1,175 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

lnterleukin-2 programs mouse αβ T lymphocytes for apoptosis

1991 • 1,027 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

CTLA-4-Mediated Inhibition in Regulation of T Cell Responses: Mechanisms and Manipulation in Tumor Immunotherapy

2001 • 964 citations

Human B7-1 (CD80) and B7-2 (CD86) bind with similar avidities but distinct kinetics to CD28 and CTLA-4 receptors

1994 • 950 citations

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells.

1996 • 917 citations

Signals and signs for lymphocyte responses

1994 • 868 citations

Helper T Cell Differentiation Is Controlled by the Cell Cycle

1998 • 862 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

Effects of sodium butyrate, a new pharmacological agent, on cells in culture

1981 • 808 citations

Dynamics of T Lymphocyte Responses: Intermediates, Effectors, and Memory Cells

2000 • 807 citations

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

1998 • 800 citations

CTLA-4 ligation blocks CD28-dependent T cell activation.

1996 • 787 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Intracellular Trafficking of CTLA-4 and Focal Localization Towards Sites of TCR Engagement

1996 • 583 citations

In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability

2000 • 445 citations

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

1995 • 429 citations

Peripheral T Cell Survival Requires Continual Ligation of the T Cell Receptor to Major Histocompatibility Complex–Encoded Molecules

1997 • 419 citations

CTLA-4-Mediated Inhibition of Early Events of T Cell Proliferation

1999 • 412 citations

CTLA-4 Regulates Induction of Anergy In Vivo

2001 • 409 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1996 • 377 citations

B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.

1994 • 367 citations

Regulation of surface and intracellular expression of CTLA4 on mouse T cells.

1996 • 340 citations

Cell division regulates the T cell cytokine repertoire, revealing a mechanism underlying immune class regulation

1998 • 332 citations

Antigen-dependent clonal expansion of a trace population of antigen-specific CD4+ T cells in vivo is dependent on CD28 costimulation and inhibited by CTLA-4.

1995 • 323 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

Ectopic Expression of Activated Stat6 Induces the Expression of Th2-Specific Cytokines and Transcription Factors in Developing Th1 Cells

1999 • 300 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

A cellular calculus for signal integration by T cells

2000 • 243 citations

Structural Analysis of CTLA-4 Function In Vivo

2000 • 236 citations

Targeted Complementation of MHC Class II Deficiency by Intrathymic Delivery of Recombinant Adenoviruses

1997 • 204 citations

A reversible arrest point in the late G1 phase of the mammalian cell cycle

1990 • 203 citations

Activation-driven T cell death. I. Requirements for de novo transcription and translation and association with genome fragmentation.

1989 • 194 citations

Signaling by the TNF Receptor Superfamily and T Cell Homeostasis

2000 • 194 citations

Instruction for Cytokine Expression in T Helper Lymphocytes in Relation to Proliferation and Cell Cycle Progression

1999 • 190 citations

Lymphoproliferative Disorder in CTLA-4 Knockout Mice Is Characterized by CD28-Regulated Activation of Th2 Responses

1999 • 182 citations

The Yin and Yang of T Cell Costimulation

1995 • 180 citations

Bcl-XL displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice.

1995 • 178 citations

Migration and Function of Antigen-Primed Nonpolarized T Lymphocytes in Vivo

2001 • 176 citations

Disruption of T cell signaling networks and development by Grb2 haploid insufficiency

2001 • 165 citations

Expression and Function of CTLA-4 in Th1 and Th2 Cells

1998 • 161 citations

The Role of CTLA-4 in Regulating Th2 Differentiation

1999 • 148 citations

Thymocyte development is normal in CTLA-4-deficient mice

1997 • 147 citations

B7-1 or B7-2 Is Required to Produce the Lymphoproliferative Phenotype in Mice Lacking Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4)

1999 • 146 citations

Blockade of CTLA-4 Enhances Host Resistance to the Intracellular Pathogen,Leishmania donovani

1998 • 135 citations

Interleukin‐12 regulates the proliferation of Th1, but not Th2 or Th0, clones

1994 • 118 citations

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4⁺T cell responses

1999 • 115 citations

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

1997 • 113 citations

Impaired Interleukin 4 Signaling in T Helper Type 1 Cells

1998 • 94 citations

Dealing from the Evolutionary Pawnshop

1999 • 81 citations

Dopamine receptors in canine caudate nucleus

1982 • 72 citations

Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

2000 • 59 citations

Action of Cytochalasin B on Cultured Human Lymphocytes

1967 • 34 citations

Interleukin-4-Independent Acceleration of Cutaneous Leishmaniasis in Susceptible BALB/c Mice following Treatment with Anti-CTLA4 Antibody

1999 • 22 citations