Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

1994 • 3,477 citations

Role of LXRs in control of lipogenesis

2000 • 1,623 citations

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβ

2000 • 1,619 citations

Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

1997 • 1,440 citations

Regulated Intramembrane Proteolysis

2000 • 1,314 citations

A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

1999 • 1,311 citations

Regulation of Absorption and ABC1-Mediated Efflux of Cholesterol by RXR Heterodimers

2000 • 1,285 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1993 • 906 citations

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 • 816 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

1998 • 797 citations

Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

1999 • 771 citations

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

1998 • 768 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

1999 • 727 citations

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

1998 • 686 citations

Sterol Regulatory Element-binding Protein-1 as a Key Transcription Factor for Nutritional Induction of Lipogenic Enzyme Genes

1999 • 668 citations

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

1998 • 658 citations

ADD1/SREBP1 activates PPARγ through the production of endogenous ligand

1998 • 647 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

ADD1: a Novel Helix-Loop-Helix Transcription Factor Associated with Adipocyte Determination and Differentiation

1993 • 575 citations

ADD1/SREBP-1c Is Required in the Activation of Hepatic Lipogenic Gene Expression by Glucose

1999 • 540 citations

Identification of Liver X Receptor-Retinoid X Receptor as an Activator of the Sterol Regulatory Element-Binding Protein 1c Gene Promoter

2001 • 523 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein

1996 • 473 citations

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

1997 • 453 citations

Physiological and molecular mechanisms involved in nutritional regulation of fatty acid synthesis

1995 • 451 citations

Unsaturated Fatty Acids Down-regulate SREBP Isoforms 1a and 1c by Two Mechanisms in HEK-293 Cells

2001 • 438 citations

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

1997 • 438 citations

Regulation of Peroxisome Proliferator-Activated Receptor γ Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism

1999 • 424 citations

ABC1 Gene Expression and ApoA-I-Mediated Cholesterol Efflux Are Regulated by LXR

2000 • 407 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

1993 • 396 citations

Fish Oil Feeding Decreases Mature Sterol Regulatory Element-binding Protein 1 (SREBP-1) by Down-regulation of SREBP-1c mRNA in Mouse Liver

1999 • 375 citations

A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids

1999 • 364 citations

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation.

1993 • 351 citations

Two Tandem Binding Sites for Sterol Regulatory Element Binding Proteins Are Required for Sterol Regulation of Fatty-acid Synthase Promoter

1996 • 331 citations

Dual DNA Binding Specificity of ADD1/SREBP1 Controlled by a Single Amino Acid in the Basic Helix-Loop-Helix Domain

1995 • 326 citations

Sterol Regulation of Fatty Acid Synthase Promoter

1995 • 323 citations

Polyunsaturated Fatty Acids Decrease Expression of Promoters with Sterol Regulatory Elements by Decreasing Levels of Mature Sterol Regulatory Element-binding Protein

1998 • 321 citations

Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.

1996 • 318 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

1993 • 300 citations

Cooperation by Sterol Regulatory Element-binding Protein and Sp1 in Sterol Regulation of Low Density Lipoprotein Receptor Gene

1995 • 295 citations

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

1995 • 291 citations

Sterol-dependent Transcriptional Regulation of Sterol Regulatory Element-binding Protein-2

1996 • 274 citations

Sterol regulation of acetyl coenzyme A carboxylase: a mechanism for coordinate control of cellular lipid.

1996 • 257 citations

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes

2000 • 256 citations

Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

1997 • 256 citations

Promoter Analysis of the Mouse Sterol Regulatory Element-binding Protein-1c Gene

2000 • 254 citations

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

1990 • 236 citations

Identification of Glycerol-3-phosphate Acyltransferase as an Adipocyte Determination and Differentiation Factor 1- and Sterol Regulatory Element-binding Protein-responsive Gene

1997 • 229 citations

A Direct Role for Sterol Regulatory Element Binding Protein in Activation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Gene

1996 • 228 citations

Identification of Conserved cis-Elements and Transcription Factors Required for Sterol-regulated Transcription of Stearoyl-CoA Desaturase 1 and 2

1999 • 225 citations

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein

1997 • 223 citations

Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins

1998 • 222 citations

Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating Protein

1998 • 215 citations

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

1994 • 199 citations

Sterol Regulatory Element-binding Protein Negatively Regulates Microsomal Triglyceride Transfer Protein Gene Transcription

1999 • 197 citations

Sterol Response Element-binding Protein 1c (SREBP1c) Is Involved in the Polyunsaturated Fatty Acid Suppression of Hepatic S14 Gene Transcription

1999 • 196 citations

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1998 • 195 citations

Sterol Regulation of 3-Hydroxy-3-Methylglutaryl-coenzyme A Synthase Gene through a Direct Interaction Between Sterol Regulatory Element Binding Protein and the Trimeric CCAAT-binding Factor/Nuclear Factor Y

1998 • 184 citations

p38 Mitogen-activated Protein Kinase Down-regulates Nitric Oxide and Up-regulates Prostaglandin E2 Biosynthesis Stimulated by Interleukin-1β

1997 • 181 citations

Dietary Regulation of Gene Expression: Enzymes Involved in Carbohydrate and Lipid Metabolism

1987 • 178 citations

Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins

1999 • 176 citations

Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein

1999 • 171 citations

Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2

1997 • 170 citations

Multiple sterol regulatory elements in promoter for hamster 3-hydroxy-3-methylglutaryl-coenzyme A synthase.

1988 • 165 citations

Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene.

1996 • 159 citations

Different Sterol Regulatory Element-binding Protein-1 Isoforms Utilize Distinct Co-regulatory Factors to Activate the Promoter for Fatty Acid Synthase

2000 • 155 citations

Second-site Cleavage in Sterol Regulatory Element-binding Protein Occurs at Transmembrane Junction as Determined by Cysteine Panning

1998 • 150 citations

Tumor Necrosis Factor-α Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase

1998 • 146 citations

Sterol Regulatory Element-binding Protein-1 Is Regulated by Glucose at the Transcriptional Level

2000 • 142 citations

Transcriptional Regulation of the ATP Citrate-lyase Gene by Sterol Regulatory Element-binding Proteins

2000 • 130 citations

Orexin Receptors Are Expressed in the Adrenal Medulla of the Rat

1999 • 125 citations

Nuclear Import of Sterol Regulatory Element–binding Protein-2, a Basic Helix-Loop-Helix–Leucine Zipper (bHLH-Zip)–containing Transcription Factor, Occurs through the Direct Interaction of Importin β with HLH-Zip

1999 • 124 citations

Co-crystal structure of sterol regulatory element binding protein 1a at 2.3 å resolution

1998 • 123 citations

Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins

1997 • 119 citations

Structure of the Human Gene Encoding Sterol Regulatory Element Binding Protein 2 (SREBF2)

1997 • 117 citations

Sterol Regulatory Element-Binding Protein-1a Binds to cis Elements in the Promoter of the Rat High Density Lipoprotein Receptor SR-BI Gene1

1999 • 113 citations

Transcriptional Activation of the Stearoyl-CoA Desaturase 2 Gene by Sterol Regulatory Element-binding Protein/Adipocyte Determination and Differentiation Factor 1

1998 • 109 citations

Nutrient regulation of gene expression by the sterol regulatory element binding proteins: Increased recruitment of gene-specific coregulatory factors and selective hyperacetylation of histone H3 in vivo

2000 • 107 citations

Multiple Sequence Elements are Involved in the Transcriptional Regulation of the Human Squalene Synthase Gene

1997 • 106 citations

Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1

1997 • 106 citations

Synergistic Binding of Sterol Regulatory Element-binding Protein and NF-Y to the Farnesyl Diphosphate Synthase Promoter Is Critical for Sterol-regulated Expression of the Gene

1996 • 102 citations

Respective roles of glucose, fructose, and insulin in the regulation of the liver-specific pyruvate kinase gene promoter.

1994 • 92 citations

Promoter Selective Transcriptional Synergy Mediated by Sterol Regulatory Element Binding Protein and Sp1: a Critical Role for the Btd Domain of Sp1

1997 • 89 citations

Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein 1 of low density lipoprotein receptor promoter.

1995 • 89 citations

Induction of fatty acid synthase and S14 gene expression by glucose, xylitol and dihydroxyacetone in cultured rat hepatocytes is closely correlated with glucose 6-phosphate concentrations

1997 • 86 citations

Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites

2000 • 82 citations

A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.

2000 • 80 citations

Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes

2000 • 79 citations

Oleate Potentiates Oxysterol Inhibition of Transcription from Sterol Regulatory Element-1-regulated Promoters and Maturation of Sterol Regulatory Element-binding Proteins

1998 • 78 citations

Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein

1998 • 77 citations

Co-stimulation of Promoter for Low Density Lipoprotein Receptor Gene by Sterol Regulatory Element-binding Protein and Sp1 Is Specifically Disrupted by the Yin Yang 1 Protein

1999 • 76 citations

Cyclic Adenosine 3′,5′-Monophosphate(cAMP)/cAMP-Responsive Element Modulator (CREM)-Dependent Regulation of Cholesterogenic Lanosterol 14α-Demethylase (CYP51) in Spermatids

1999 • 73 citations

Conditional Response of the Human Steroidogenic Acute Regulatory Protein Gene Promoter to Sterol Regulatory Element Binding Protein-1a*

2001 • 72 citations

A Critical Role for cAMP Response Element-binding Protein (CREB) as a Co-activator in Sterol-regulated Transcription of 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase Promoter

1999 • 72 citations

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

1998 • 70 citations

Multiple DNA Elements for Sterol Regulatory Element-Binding Protein and NF-Y Are Responsible for Sterol-Regulated Transcription of the Genes for Human 3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase and Squalene Synthase

1998 • 65 citations

Identification of Diazepam-binding Inhibitor/Acyl-CoA-binding Protein as a Sterol Regulatory Element-binding Protein-responsive Gene

1998 • 61 citations

YY1 Is a Negative Regulator of Transcription of Three Sterol Regulatory Element-binding Protein-responsive Genes

1999 • 58 citations

Characterization of a cholesterol response element (CRE) in the promoter of the cholesteryl ester transfer protein gene: functional role of the transcription factors SREBP-1a, -2, and YY1.

1999 • 54 citations

The Roles of Sterol Regulatory Element-binding Proteins in the Transactivation of the Rat ATP Citrate-Lyase Promoter

2000 • 54 citations

Sp1 and Sp3 transactivate the human lipoprotein lipase gene promoter through binding to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant

1998 • 52 citations

Yin Yang 1 Protein Negatively Regulates High-Density Lipoprotein Receptor Gene Transcription by Disrupting Binding of Sterol Regulatory Element Binding Protein to the Sterol Regulatory Element¹

2001 • 28 citations

Molecular Cloning of the Promoter for Rat Hepatic Neutral Cholesterol Ester Hydrolase: Evidence for Transcriptional Regulation by Sterols

1998 • 23 citations

Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene

1999 • 22 citations