Failure to Cleave Sterol Regulatory Element-binding Proteins (SREBPs) Causes Cholesterol Auxotrophy in Chinese Hamster Ovary Cells with Genetic Absence of SREBP Cleavage-activating Protein

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

[19] Receptor-mediated endocytosis of low-density lipoprotein in cultured cells

1983 • 1,639 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1997 • 797 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Sterol Resistance in CHO Cells Traced to Point Mutation in SREBP Cleavage–Activating Protein

1996 • 473 citations

Complementation Cloning of , a Gene Encoding a Putative Metalloprotease Required for Intramembrane Cleavage of SREBPs

1997 • 453 citations

Molecular Identification of the Sterol-Regulated Luminal Protease that Cleaves SREBPs and Controls Lipid Composition of Animal Cells

1998 • 400 citations

Intracellular Trafficking of Cholesterol Monitored with a Cyclodextrin

1996 • 366 citations

Sterol regulatory element-binding proteins

1999 • 315 citations

Identification of Complexes between the COOH-terminal Domains of Sterol Regulatory Element-binding Proteins (SREBPs) and SREBP Cleavage-Activating Protein

1997 • 223 citations

Differential Stimulation of Cholesterol and Unsaturated Fatty Acid Biosynthesis in Cells Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins

1998 • 222 citations

Cleavage of Sterol Regulatory Element-binding Proteins (SREBPs) at Site-1 Requires Interaction with SREBP Cleavage-activating Protein

1998 • 215 citations

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

1994 • 199 citations

Regulated Cleavage of Sterol Regulatory Element Binding Proteins Requires Sequences on Both Sides of the Endoplasmic Reticulum Membrane

1996 • 198 citations

Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro

1998 • 195 citations

Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing Domain

1998 • 187 citations

Autocatalytic Processing of Site-1 Protease Removes Propeptide and Permits Cleavage of Sterol Regulatory Element-binding Proteins

1999 • 176 citations

Cleavage Site for Sterol-regulated Protease Localized to a Leu-Ser Bond in the Lumenal Loop of Sterol Regulatory Element-binding Protein-2

1997 • 170 citations

cDNA cloning and expression of the peptide-binding β subunit of rat p21rasfarnesyltransferase, the counterpart of yeast DPR1/RAM1

1991 • 166 citations

Loss of transcriptional repression of three sterol-regulated genes in mutant hamster cells

1989 • 161 citations

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N

1998 • 129 citations

Reconstituted low density lipoprotein: A vehicle for the delivery of hydrophobic fluorescent probes to cells

1979 • 111 citations

Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines

1995 • 96 citations

Isolation of Cholesterol-requiring Mutant Chinese Hamster Ovary Cells with Defects in Cleavage of Sterol Regulatory Element-binding Proteins at Site 1

1998 • 95 citations

A Critical Role for cAMP Response Element-binding Protein (CREB) as a Co-activator in Sterol-regulated Transcription of 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase Promoter

1999 • 72 citations

Recurrent G-to-A substitution in a single codon of SREBP cleavage-activating protein causes sterol resistance in three mutant Chinese hamster ovary cell lines

1996 • 61 citations

Somatic cell genetic and biochemical characterization of cell lines resulting from human genomic DNA transfections of Chinese hamster ovary cell mutants defective in sterol-dependent activation of sterol synthesis and LDL receptor expression

1994 • 54 citations

Revertants of a Chinese hamster ovary cell mutant resistant to suppression by an analog of cholesterol: isolation and partial biochemical characterization

1982 • 47 citations