Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The SREBP Pathway: Regulation of Cholesterol Metabolism by Proteolysis of a Membrane-Bound Transcription Factor

1997 • 3,702 citations

Inducible Gene Targeting in Mice

1995 • 1,897 citations

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

1993 • 1,578 citations

Positional cloning of the mouse obese gene and its human homologue

1995 • 1,164 citations

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

1996 • 1,004 citations

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

1997 • 816 citations

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

1996 • 802 citations

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

1997 • 744 citations

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

1994 • 704 citations

SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.

1993 • 593 citations

Sterol-Regulated Release of SREBP-2 from Cell Membranes Requires Two Sequential Cleavages, One Within a Transmembrane Segment

1996 • 515 citations

Adipocyte P2 gene: developmental expression and homology of 5'-flanking sequences among fat cell-specific genes.

1986 • 334 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

The sequence of cDNA encoding lipoprotein lipase. A member of a lipase gene family.

1987 • 300 citations

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

1995 • 291 citations

Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1).

1994 • 199 citations

Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.

1995 • 189 citations

Hairpin Orientation of Sterol Regulatory Element-binding Protein-2 in Cell Membranes as Determined by Protease Protection

1995 • 153 citations

Structure of the Human Gene Encoding Sterol Regulatory Element Binding Protein 2 (SREBF2)

1997 • 117 citations

Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.

1994 • 110 citations

Three Different Rearrangements in a Single Intron Truncate Sterol Regulatory Element Binding Protein-2 and Produce Sterol-resistant Phenotype in Three Cell Lines

1995 • 96 citations

Molecular cloning and promoter analysis of the rat liver farnesyl diphosphate synthase gene.

1992 • 56 citations

Isolation and Characterization of the Gene for Mouse Hormone-Sensitive Lipase

1994 • 45 citations

Chinese hamster ovary cell mutants affecting cholesterol metabolism

1997 • 32 citations