Cell birth, cell death, cell diversity and DNA breaks: how do they all fit together?

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9

1998 • 1,642 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo

1998 • 1,292 citations

Apoptotic Pathways

1998 • 1,193 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps

1995 • 703 citations

A Critical Role for DNA End-Joining Proteins in Both Lymphogenesis and Neurogenesis

1998 • 668 citations

Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

1997 • 667 citations

The cell cycle of the pseudostratified ventricular epithelium of the embryonic murine cerebral wall

1995 • 662 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

DNA end-joining: from yeast to man

1998 • 586 citations

Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

1998 • 581 citations

Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex

1996 • 540 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

1998 • 435 citations

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

1998 • 431 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex

1997 • 370 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis

1996 • 331 citations

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

1998 • 323 citations

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1998 • 292 citations

The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system

1991 • 288 citations

Local Differences in the Amount of Early Cell Death in Neocortex Predict Adult Local Specializations

1983 • 279 citations

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

1997 • 267 citations

Molecular Cloning and Expression of Human cDNAs Encoding a Novel DNA Ligase IV and DNA Ligase III, an Enzyme Active in DNA Repair and Recombination

1995 • 254 citations

DNA looping by Ku and the DNA-dependent protein kinase

1997 • 249 citations

BUdR as an S-phase marker for quantitative studies of cytokinetic behaviour in the murine cerebral ventricular zone

1992 • 241 citations

Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant.

1994 • 238 citations

Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system

1998 • 236 citations

Cell proliferation in the neural tube: An electron microscopic and Golgi analysis in the mouse cerebral vesicle

1971 • 227 citations

The site of origin and route and rate of migration of neurons to the hippocampal region of the rhesus monkey

1981 • 209 citations

Cell death and removal in the cerebral cortex during development

1992 • 208 citations

Recent Advances in Understanding V(D)J Recombination

1997 • 196 citations

DNA binding of Xrcc4 protein is associated with V(D)Jrecombination but not with stimulation of DNA ligase IV activity

1999 • 179 citations

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA

1996 • 175 citations

Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell

1983 • 170 citations

In situ labeling of apoptotic cell death in the cerebral cortex and thalamus of rats during development

1995 • 160 citations

Generation times of the matrix cells during embryonic brain development: An autoradiographic study in rats

1972 • 124 citations

Detection of Somatic DNA Recombination in the Transgenic Mouse Brain

1991 • 121 citations

Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall

1996 • 114 citations

A gradient in the duration of the G1 phase in the murine neocortical proliferative epithelium

1997 • 112 citations

Independent Controls for Neocortical Neuron Production and Histogenetic Cell Death

2000 • 100 citations

An electron microscope study of cells in the matrix and intermediate laminae of the cerebral hemisphere of the 45 mm rabbit embryo

1968 • 82 citations

Rearranging Views on Neurogenesis

1999 • 76 citations

Variability and partial synchrony of the cell cycle in the germinal zone of the early embryonic cerebral cortex

1995 • 48 citations

Genetic analysis of XR-1 mutation in hamster and human hybrids

1989 • 13 citations