Key features of heat shock regulatory elements.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Heat shock, from bacteria to man

1982 • 1,260 citations

A regulatory upstream promoter element in the Drosophila Hsp 70 heat-shock gene

1982 • 1,038 citations

Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

1985 • 860 citations

A drosophila RNA polymerase II transcription factor binds to the regulatory site of an hsp 70 gene

1984 • 534 citations

Germline Transformation Used to Define Key Features of Heat-Shock Response Elements

1988 • 451 citations

Purification and Properties of Drosophila Heat Shock Activator Protein

1987 • 388 citations

Transient expression of genes introduced into cultured cells of Drosophila.

1983 • 370 citations

Activating protein factor binds in vitro to upstream control sequences in heat shock gene chromatin

1984 • 329 citations

Human HSP70 promoter contains at least two distinct regulatory domains.

1986 • 326 citations

New heat shock puffs and β=galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene

1983 • 323 citations

Sequences required for in vitro transcriptional activation of a Drosophila hsp 70 gene

1985 • 291 citations

Determinants of heat shock-induced chromosome puffing

1985 • 281 citations

Activation of heat-shock genes in eukaryotes

1985 • 263 citations

Heat shock regulatory elements function as an inducible enhancer in the xenopus hsp70 gene and when linked to a heterologous promoter

1986 • 239 citations

Heat-Inducible Human Factor That Binds to a Human hsp70 Promoter

1987 • 232 citations

The saccharomyces and Drosophila heat shock transcription factors are identical in size and DNA binding properties

1987 • 214 citations

An underlying repeat in some transcriptional control sequences corresponding to half a double helical turn of DNA

1986 • 214 citations

Upstream elements necessary for optimal function of the hsp 70 promoter in transformed flies

1984 • 213 citations

Integration, transcription, and control of a Drosophila heat shock gene in mouse cells.

1981 • 212 citations

Nucleotide sequence analysis of the Drosophila small heat shock gene cluster at locus 67B

1983 • 198 citations

Sequence homologies in the 5' regions of four Drosophila heat-shock genes.

1981 • 188 citations

The use of promoter fusions in Drosophila genetics: Isolation of mutations affecting the heat shock response

1984 • 172 citations

Regulation of heat-shock genes: a DNA sequence upstream of Drosophila hsp70 genes is essential for their induction in monkey cells.

1982 • 171 citations

Isolation and functional analysis of a human 70,000-dalton heat shock protein gene segment.

1985 • 164 citations

Extensive regions of homology in front of the two hsp70 heat shock variant genes in Drosophila melanogaster

1981 • 161 citations

Separate regulatory elements for the heat-inducible and ovarian expression of the drosophila hsp26 gene

1985 • 138 citations

The Chicken Ubiquitin Gene Contains a Heat Shock Promoter and Expresses an Unstable mRNA in Heat-Shocked Cells

1986 • 137 citations

Heat-inducible human factor that binds to a human hsp70 promoter.

1987 • 132 citations

Transcriptional regulation of an hsp70 heat shock gene in the yeast Saccharomyces cerevisiae.

1987 • 128 citations

Activation of the Drosophila hsp27 promoter by heat shock and by ecdysone involves independent and remote regulatory sequences

1986 • 128 citations

Organization, nucleotide sequence, and transcription of the chicken HSP70 gene.

1986 • 122 citations

Genes for Low-Molecular-Weight Heat Shock Proteins of Soybeans: Sequence Analysis of a Multigene Family

1985 • 114 citations

Heat shock and ecdysterone activation of the Drosophila melanogaster hsp23 gene; a sequence element implied in developmental regulation.

1986 • 112 citations

Locus Encoding a Family of Small Heat Shock Genes in Caenorhabditis elegans: Two Genes Duplicated to Form a 3.8-Kilobase Inverted Repeat

1985 • 110 citations

Transcription of a Drosophila heat shock gene is heat-induced in Xenopus oocytes.

1982 • 102 citations

Bending of promoter DNA on binding of heat shock transcription factor

1986 • 101 citations

The chicken ubiquitin gene contains a heat shock promoter and expresses an unstable mRNA in heat-shocked cells.

1986 • 94 citations

Binding of Drosophila heat-shock gene transcription factor to the hsp 70 promoter. Evidence for symmetric and dynamic interactions.

1986 • 93 citations

Two genes for the major heat-shock protein of Drosophila melanogaster arranged as an inverted repeat

1980 • 89 citations

Expression of a Drosophila heat-shock protein in Xenopus oocytes: conserved and divergent regulatory signals.

1982 • 85 citations

Expression of heat shock genes in homologous and heterologous systems

1987 • 85 citations

The Heat Shock Consensus Sequence Is Not Sufficient for hsp70 Gene Expression in Drosophila melanogaster

1985 • 73 citations

Genes for low-molecular-weight heat shock proteins of soybeans: sequence analysis of a multigene family.

1985 • 66 citations

Locus encoding a family of small heat shock genes in Caenorhabditis elegans: two genes duplicated to form a 3.8-kilobase inverted repeat.

1985 • 61 citations

Organization of the Drosophila melanogaster hsp70 heat shock regulation unit.

1987 • 57 citations

Sequence requirement for expression of the Drosophila melanogaster heat shock protein hsp22 gene during heat shock and normal development.

1986 • 55 citations

Transcriptional Regulation of an hsp70 Heat Shock Gene in the Yeast Saccharomyces Cerevisiae

1987 • 53 citations

Inducible transcription and puffing in Drosophila melanogaster transformed with hsp70-phage lambda hybrid heat shock genes.

1984 • 51 citations

Several hundred base pairs upstream of Drosophila hsp23 and 26 genes are required for their heat induction in transformed flies.

1986 • 50 citations

Efficient transcription of a Caenorhabditis elegans heat shock gene pair in mouse fibroblasts is dependent on multiple promoter elements which can function bidirectionally.

1986 • 45 citations

The heat shock consensus sequence is not sufficient for hsp70 gene expression in Drosophila melanogaster.

1985 • 36 citations

Ecdysterone selectively stimulates the expression of a 23000-Da heat-shock protein-β-galactosidase hybrid gene in cultured Drosophila cells

1985 • 35 citations

Identification of a sequence element in the promoter of the Drosophila melanogaster hsp23 gene that is required for its heat activation.

1985 • 26 citations