A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

A second generation human haplotype map of over 3.1 million SNPs

2007 • 4,436 citations

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

2003 • 2,133 citations

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood

2003 • 1,887 citations

TLR signaling

2007 • 1,296 citations

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

2008 • 1,273 citations

JAK-STAT Signaling: From Interferons to Cytokines

2007 • 1,193 citations

TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY

2004 • 1,157 citations

STAT4and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus

2007 • 1,008 citations

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

2008 • 887 citations

A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus

2006 • 661 citations

Mapping determinants of human gene expression by regional and genome-wide association

2005 • 598 citations

Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus

2005 • 591 citations

Stat3 and Stat4 Direct Development of IL-17-Secreting Th Cells

2007 • 540 citations

Model-based variance-stabilizing transformation for Illumina microarray data

2008 • 501 citations

Critical Role for STAT4 Activation by Type 1 Interferons in the Interferon-γ Response to Viral Infection

2002 • 476 citations

Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

2000 • 454 citations

A Comparison of Phasing Algorithms for Trios and Unrelated Individuals

2006 • 345 citations

The type I interferon system in systemic lupus erythematosus

2006 • 335 citations

Genome-wide analysis of transcript isoform variation in humans

2008 • 309 citations

Combining Information from Common Type 2 Diabetes Risk Polymorphisms Improves Disease Prediction

2006 • 268 citations

Infection, vaccines and other environmental triggers of autoimmunity

2005 • 235 citations

Differential Allelic Expression in the Human Genome: A Robust Approach To Identify Genetic and Epigenetic Cis-Acting Mechanisms Regulating Gene Expression

2008 • 219 citations

Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus

2007 • 191 citations

Association of a haplotype in the promoter region of the interferon regulatory factor 5 gene with rheumatoid arthritis

2007 • 190 citations

STAT4: A Critical Regulator of Inflammation In Vivo

2005 • 186 citations

Review: IFN-α/βReceptor Interactions to Biologic Outcomes: Understanding the Circuitry

2002 • 185 citations

An insertion deletion polymorphism in the Interferon Regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases

2007 • 182 citations

Microarray analysis of gene expression in lupus.

2003 • 180 citations

Association of STAT4 with Rheumatoid Arthritis in the Korean Population

2007 • 173 citations

High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells

2007 • 161 citations

Notch regulates IL-10 production by T helper 1 cells

2008 • 143 citations

Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations

2008 • 142 citations

IFN-α Priming Results in a Gain of Proinflammatory Function by IL-10: Implications for Systemic Lupus Erythematosus Pathogenesis

2004 • 135 citations

Survey of allelic expression using EST mining

2005 • 134 citations

Signaling through IFN Regulatory Factor-5 Sensitizes p53-Deficient Tumors to DNA Damage–Induced Apoptosis and Cell Death

2005 • 115 citations

Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice

2003 • 108 citations

Distinct requirements for the naturally occurring splice forms Stat4 and Stat4 in IL-12 responses

2003 • 95 citations

Mapping common regulatory variants to human haplotypes

2005 • 89 citations

Stat4-dependent, T-bet-independent regulation of IL-10 in NK cells

2008 • 70 citations

Association of polymorphisms across the tyrosine kinase gene, TYK2 in UK SLE families

2007 • 70 citations

Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-α/β on antigen cross-presentation

2006 • 63 citations

Vitamin D Receptor 3′ Haplotypes Are Unequally Expressed in Primary Human Bone Cells and Associated With Increased Fracture Risk: The MrOS Study in Sweden and Hong Kong

2007 • 43 citations

Systematic assessment of the human osteoblast transcriptome in resting and induced primary cells

2008 • 38 citations

NF-κB is required for STAT-4 expression during dendritic cell maturation

2006 • 37 citations

Type I Interferons Inhibition of Inflammatory T Helper Cell Responses in Systemic Lupus Erythematosus

2007 • 28 citations

Deleted Work

1955 • 0 citations