JAK-STAT Signaling: From Interferons to Cytokines

Virus interference. I. The interferon

1957 • 3,331 citations

STATs: transcriptional control and biological impact

2002 • 3,050 citations

Stat3 as an Oncogene

1999 • 2,770 citations

Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

1996 • 1,648 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

STATs: Signal Transducers and Activators of Transcription

1996 • 1,414 citations

Signaling through the JAK/STAT pathway, recent advances and future challenges

2002 • 1,132 citations

Cytokine Signaling in 2002

2002 • 1,089 citations

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

1994 • 1,015 citations

Interferon-Dependent Tyrosine Phosphorylation of a Latent Cytoplasmic Transcription Factor

1992 • 906 citations

A protein tyrosine kinase in the interferon αβ signaling pathway

1992 • 876 citations

Serine phosphorylation of STATs

2000 • 873 citations

New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

2005 • 844 citations

Activation of Transcription by IFN-γ: Tyrosine Phosphorylation of a 91-kD DNA Binding Protein

1992 • 772 citations

Three-dimensional structure of the Stat3β homodimer bound to DNA

1998 • 769 citations

Stat3 Dimerization Regulated by Reversible Acetylation of a Single Lysine Residue

2005 • 737 citations

T<scp>he</scp>R<scp>ole of</scp>S<scp>uppressors of</scp>C<scp>ytokine</scp>S<scp>ignaling</scp>(SOCS) P<scp>roteins in</scp>R<scp>egulation of the</scp>I<scp>mmune</scp>R<scp>esponse</scp>

2004 • 696 citations

Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA

1998 • 696 citations

Erythropoietin Receptor Activation by a Ligand-Induced Conformation Change

1999 • 624 citations

The Yin and Yang of type I interferon activity in bacterial infection

2005 • 460 citations

Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction.

1989 • 413 citations

Immune Response in Stat2 Knockout Mice

2000 • 399 citations

Novel Roles of Unphosphorylated STAT3 in Oncogenesis and Transcriptional Regulation

2005 • 392 citations

Modulation of STAT signaling by STAT-interacting proteins

2000 • 372 citations

Stat5a/b are essential for normal lymphoid development and differentiation

2006 • 369 citations

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

2003 • 357 citations

Protein tyrosine phosphatases and the immune response

2005 • 348 citations

Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity

2007 • 326 citations

tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.

1990 • 322 citations

Signaling mechanisms, interaction partners, and target genes of STAT6

2006 • 287 citations

Activation of Stat3 Sequence-specific DNA Binding and Transcription by p300/CREB-binding Protein-mediated Acetylation

2005 • 259 citations

Phosphorylation of the Stat1 Transactivation Domain Is Required for Full-Fledged IFN-γ-Dependent Innate Immunity

2003 • 258 citations

Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation

2003 • 257 citations

PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity

2004 • 256 citations

Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

2001 • 248 citations

Acetylation of Stat1 modulates NF-κB activity

2006 • 202 citations

STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation

2002 • 202 citations

Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation

2003 • 200 citations

SLIM Is a Nuclear Ubiquitin E3 Ligase that Negatively Regulates STAT Signaling

2005 • 186 citations

Novel STAT1 Alleles in Otherwise Healthy Patients with Mycobacterial Disease

2006 • 184 citations

Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II

2002 • 170 citations

The Coactivator of Transcription CREB-binding Protein Interacts Preferentially with the Glycosylated Form of Stat5

2004 • 166 citations

Dephosphorylation of phosphotyrosine on STAT1 dimers requires extensive spatial reorientation of the monomers facilitated by the N-terminal domain

2006 • 155 citations

Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes

2002 • 155 citations

Functional Interaction of STAT3 Transcription Factor with the Coactivator NcoA/SRC1a

2002 • 143 citations

Regulation of Stat3 nuclear export

2003 • 139 citations

Specific Ablation of Stat3β Distorts the Pattern of Stat3-Responsive Gene Expression and Impairs Recovery from Endotoxic Shock

2002 • 137 citations

Stat3 activation of NF-κB p100 processing involves CBP/p300-mediated acetylation

2006 • 130 citations

A small amphipathic alpha -helical region is required for transcriptional activities and proteasome-dependent turnover of the tyrosine-phosphorylated Stat5

2000 • 121 citations

Mutational Analysis of Acute-Phase Response Factor/Stat3 Activation and Dimerization

1997 • 121 citations

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

2002 • 119 citations

Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-induciblegbp2gene

2007 • 118 citations

Interferon-gamma-induced chromatin remodeling at the CIITA locus is BRG1 dependent

2002 • 116 citations

Getting the message across, STAT! Design principles of a molecular signaling circuit

2004 • 115 citations

Maximal Induction of a Subset of Interferon Target Genes Requires the Chromatin-Remodeling Activity of the BAF Complex

2002 • 112 citations

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFβ-activated kinase 1 for STAT3 Ser-727 phosphorylation

2005 • 79 citations

Oncogenic mechanisms in myeloproliferative disorders

2006 • 79 citations

Chromatin remodeling by the SWI/SNF-like BAF complex and STAT4 activation synergistically induce IL-12Rβ2 expression during human Th1 cell differentiation

2007 • 77 citations

Role of Metazoan Mediator Proteins in Interferon-Responsive Transcription

2003 • 71 citations

Are STATS Arginine-methylated?

2005 • 70 citations

Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL

2007 • 67 citations

Structure of the Mouse Stat 3/5 Locus: Evolution from Drosophila to Zebrafish to Mouse

2001 • 66 citations

An LXXLL Motif in the Transactivation Domain of STAT6 Mediates Recruitment of NCoA-1/SRC-1

2002 • 57 citations

Human Tyk2 Kinase Deficiency: Another Primary Immunodeficiency Syndrome

2006 • 55 citations

Stat1 and SUMO modification

2006 • 50 citations

Signal transducers and activators of transcription (STATs) : activation and biology

2003 • 43 citations

Unexpected Roles for Deacetylation in Interferon- and Cytokine-Induced Transcription

2005 • 27 citations

STAT5 acts as a repressor to regulate early embryonic erythropoiesis

2006 • 10 citations

Regulation of STATs by Posttranslational Modifications

2003 • 3 citations