Signaling through IFN Regulatory Factor-5 Sensitizes p53-Deficient Tumors to DNA Damage–Induced Apoptosis and Cell Death

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Activation of the interferon system by short-interfering RNAs

2003 • 1,416 citations

Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

1988 • 984 citations

Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors

2005 • 973 citations

Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence

2003 • 835 citations

A motif-based profile scanning approach for genome-wide prediction of signaling pathways

2001 • 517 citations

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1

1994 • 490 citations

The Interferon Regulatory Factor, IRF5, Is a Central Mediator of Toll-like Receptor 7 Signaling

2005 • 387 citations

Virus-specific Activation of a Novel Interferon Regulatory Factor, IRF-5, Results in the Induction of Distinct Interferon α Genes

2001 • 374 citations

Induction of endogenous IFN-α and IFN-β genes by a regulatory transcription factor, IRF-1

1989 • 368 citations

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

1997 • 364 citations

Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

1994 • 359 citations

Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

1996 • 326 citations

Alpha/Beta Interferons Potentiate Virus-Induced Apoptosis through Activation of the FADD/Caspase-8 Death Signaling Pathway

2000 • 293 citations

Interferon-γ Modulates a p53-independent Apoptotic Pathway and Apoptosis-related Gene Expression

1997 • 276 citations

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses

2003 • 273 citations

Preferential induction of apoptosis by interferon (IFN)-beta compared with IFN-alpha2: correlation with TRAIL/Apo2L induction in melanoma cell lines.

2001 • 245 citations

Multiple Regulatory Domains of IRF-5 Control Activation, Cellular Localization, and Induction of Chemokines That Mediate Recruitment of T Lymphocytes

2002 • 243 citations

Mechanisms of Interferon-alpha induced apoptosis in malignant cells

2002 • 218 citations

Global and Distinct Targets of IRF-5 and IRF-7 during Innate Response to Viral Infection

2004 • 217 citations

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

2001 • 201 citations

Activation of IFN-βelement by IRF-1 requires a post-translational event in addition to IRF-1 synthesis

1991 • 201 citations

Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death.

2003 • 165 citations

Phosphorylation Events Modulate the Ability of Interferon Consensus Sequence Binding Protein to Interact with Interferon Regulatory Factors and to Bind DNA

1997 • 162 citations

Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53

2002 • 155 citations

Two Discrete Promoters Regulate the Alternatively Spliced Human Interferon Regulatory Factor-5 Isoforms

2005 • 152 citations

Tumor suppressor IRF-1 mediates retinoid and interferon anticancer signaling to death ligand TRAIL

2004 • 140 citations

The role of interferon regulatory factors in the interferon system and cell growth control

1998 • 134 citations

Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53

1999 • 123 citations

IRF-1: the transcription factor linking the interferon response and oncogenesis

1997 • 121 citations

Interferon regulatory factor-3 is an in vivo target of DNA-PK

2002 • 120 citations

Virus-induced Heterodimer Formation betweenIRF-5 and IRF-7 Modulates Assembly of theIFNA Enhanceosome in Vivo and Transcriptional Activity of IFNA Genes

2003 • 117 citations

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

1995 • 109 citations

Endogenous type I interferons as a defense against tumors

2002 • 96 citations

Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway

2002 • 84 citations

Activation and repression of the 2-5A synthetase and p21 gene promoters by IRF-1 and IRF-2

1999 • 68 citations

Expression of the protein kinase PKR in modulated by IRF-1 and is reduced in 5q- associated leukemias.

1996 • 67 citations

Elimination of Hepatic Metastases of Colon Cancer Cells via p53-Independent Cross-Talk between Irinotecan and Apo2 Ligand/TRAIL

2004 • 67 citations

IFN-γ enhances TRAIL-induced apoptosis through IRF-1

2004 • 64 citations

Complementation of the Radiosensitive M059J Cell Line

2000 • 64 citations

Interferon-regulatory factor-1 is critical for tamoxifen-mediated apoptosis in human mammary epithelial cells

2004 • 50 citations

Irinotecan and high-dose fluorouracil/leucovorin for metastatic colorectal cancer.

2000 • 35 citations

UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer.

2000 • 26 citations

Maximal induction of p69 2′, 5′-oligoadenylate synthetase in Daudi cells requires cooperation between an ISRE and two IRF-1-like elements

1998 • 12 citations