In situ analysis of changes in telomere size during replicative aging and cell transformation.

The serial cultivation of human diploid cell strains

1961 • 7,886 citations

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Identification of a specific telomere terminal transferase activity in tetrahymena extracts

1985 • 3,331 citations

A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes.

1988 • 2,281 citations

The RNA Component of Human Telomerase

1995 • 2,243 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity.

1992 • 2,096 citations

A simple method of reducing the fading of immunofluorescence during microscopy

1981 • 1,907 citations

A theory of marginotomy

1973 • 1,770 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

Telomere reduction in human colorectal carcinoma and with ageing

1990 • 1,672 citations

A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis

1989 • 1,607 citations

Origin of Concatemeric T7DNA

1972 • 1,591 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

Longevity, senescence and the genome

1995 • 1,390 citations

Telomere elongation in immortal human cells without detectable telomerase activity.

1995 • 1,249 citations

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

1994 • 1,165 citations

Enzymatic synthesis of biotin-labeled polynucleotides: novel nucleic acid affinity probes.

1981 • 1,165 citations

Telomere loss: mitotic clock or genetic time bomb?

1991 • 1,144 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Telomere end-replication problem and cell aging

1992 • 1,044 citations

Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

1970 • 1,002 citations

A mutant with a defect in telomere elongation leads to senescence in yeast

1989 • 905 citations

Structure and variability of human chromosome ends.

1990 • 833 citations

Conservation of the human telomere sequence (TTAGGG)n among vertebrates.

1989 • 809 citations

Loss of a yeast telomere: Arrest, recovery, and chromosome loss

1993 • 787 citations

Telomerase activity in normal and malignant hematopoietic cells.

1995 • 748 citations

Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.

1993 • 743 citations

Replicative Senescence: the Human Fibroblast Comes of Age

1990 • 649 citations

Correlating telomerase activity levels with human neuroblastoma outcomes

1995 • 631 citations

Telomere length and replicative aging in human vascular tissues.

1995 • 630 citations

Telomerase activity in normal leukocytes and in hematologic malignancies

1995 • 619 citations

[Principle of marginotomy in template synthesis of polynucleotides].

1971 • 566 citations

In vivo loss of telomeric repeats with age in humans

1991 • 469 citations

Human naive and memory T lymphocytes differ in telomeric length and replicative potential.

1995 • 424 citations

Evidence for a Critical Telomere Length in Senescent Human Fibroblasts

1995 • 391 citations

Differential Expression of Telomerase Activity in Hematopoietic Progenitors from Adult Human Bone Marrow

1996 • 390 citations

Structure and polymorphism of human telomere-associated DNA

1990 • 382 citations

Telomere dynamics in an immortal human cell line.

1994 • 380 citations

Human telomeres contain at least three types of G–rich repeat distributed non-randomly

1989 • 374 citations

Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes

1994 • 360 citations

Human telomeres are attached to the nuclear matrix.

1992 • 334 citations

Telomeres and telomerase in aging and cancer

1995 • 328 citations

Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction

1988 • 279 citations

Modification of DAPI banding on human chromosomes by prestaining with a DNA-binding oligopeptide antibiotic, distamycin A

1978 • 277 citations

Analysis of genes and chromosomes by nonisotopic in situ hybridization

1991 • 240 citations

Structure and Variability of Human Chromosome Ends

1990 • 229 citations

Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.

1991 • 226 citations

Unusual chromatin in human telomeres.

1994 • 219 citations

Defining cellular senescence in IMR-90 cells: a flow cytometric analysis.

1988 • 196 citations

Cellular Senescence revisited: a review

1987 • 171 citations

Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos.

1976 • 166 citations

Doubling potential, calendar time, and donor age of human diploid cells in culture

1974 • 164 citations

Cell Cycle-Dependent Distribution of Telomeres, Centromeres, and Chromosome-Specific Subsatellite Domains in the Interphase Nucleus of Mouse Lymphocytes

1993 • 161 citations

Cell cycle dependent chromosomal movement in pre-mitotic human T-lymphocyte nuclei

1992 • 154 citations

Well-defined genome architecture in the human sperm nucleus

1995 • 144 citations

Telomeres and the functional architecture of the nucleus

1993 • 132 citations

Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism?

1995 • 121 citations

In situ hybridization to plant telomeres using synthetic oligomers

1991 • 109 citations

Aging in vitro

1974 • 89 citations

Localization of telomeres in plant interphase nuclei by in situ hybridization and 3D confocal microscopy

1991 • 89 citations

Unusual Chromatin in Human Telomeres

1994 • 88 citations

Staining of human telomeres with primed in situ labeling (PRINS)

1995 • 85 citations

Distribution of telomeric repeats and their role in the healing of broken chromosome ends in wheat

1992 • 82 citations

Telomere-related sequences at interstitial sites in the human genome

1990 • 65 citations

Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break.

1993 • 62 citations

Localization of centromeric satellite and telomeric dna sequences in dorsal root ganglion neurons, in vitro

1991 • 56 citations

Telomere G-strand structure and function analyzed by chemical protection, base analog substitution, and utilization by telomerase in vitro

1990 • 55 citations

Characterization and organization of DNA sequences adjacent to the human telomere associated repeat (TTAGGG)_n

1990 • 53 citations

Centromeres, Telomeres and Chromatin in the Interphase Nucleus of Cereals

1990 • 44 citations

Telomeres inhibit end to end fusion and enhance maintenance of linear DNA molecules injected into theParamecium primaureliamacronucleus

1991 • 39 citations

Localization of ribosomal and telomeric DNA sequences in intact plant nuclei by in‐situ hybridization and three‐dimensional optical microscopy

1990 • 35 citations

Interphase Chromosomes of Friend-S Cells Are Attached to the Matrix Structures Through the Centromeric/Telomeric Regions

1994 • 20 citations

Acquisition of Telomere Repeat Sequences by Transfected DNA Integrated at the Site of a Chromosome Break

1993 • 17 citations

RABL DISTRIBUTION OF INTERPHASE AND PROPHASE TELOMERES IN ALLIUM CEPA NOT ALTERED BY COLCHICINE AND/OR ULTRACENTRIFUGATION

1992 • 11 citations